HOME >> MEDICINE >> NEWS
Researchers find why prostate drug increases likelihood of heart failure

Doxazosin, a drug commonly prescribed to help improve urinary flow in men with enlarged prostates, increases the likelihood of heart failure by blocking specific receptors in heart muscle cells, according to a study conducted at the San Francisco VA Medical Center.

The cell receptors, named alpha 1-adrenergic receptors, increase the contraction of smooth muscles. Drugs such as doxazosin promote better urinary flow by blocking the action of these receptors, thus relaxing the muscles that control the flow of urine.

In the study, mice that lacked alpha 1 receptors were subjected to conditions mimicking high blood pressure. Half died of heart failure and the rest developed dilated cardiomyopathy, a severe form of heart disease. Both outcomes were apparently due to loss of alpha 1 signaling ability in heart muscle cells.

One hundred percent of normal mice survived when subjected to the same conditions. The study appears in the April, 2006 issue of Journal of Clinical Investigation.

"While you can't jump to conclusions about humans based on mouse results, it might not be a good idea to block this receptor," says principal investigator Paul C. Simpson, MD, a staff cardiologist at SFVAMC. "I think doctors and researchers need to pay more attention to the possibility that these drugs are making people worse."

The study authors note that in a large national prospective study called the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial, sponsored by the National Heart, Lung, and Blood institute and conducted from 1994 to 2002, a test of doxazosin was stopped early because subjects taking it proved to be at substantially increased risk for heart failure.

Nonetheless, according to Simpson, a very large number of men with prostate problems continue to take drugs known as alpha 1 blockers.

"This current study gives a probable mechanism for heart failure in those patients, and shows that alpha blo
'"/>

Contact: Steve Tokar
steve.tokar@ncire.org
415-221-4810 x5202
University of California - San Francisco
3-Apr-2006


Page: 1 2 3

Related medicine news :

1. Researchers suggest TB screening for all international adoptees
2. Researchers find vitamin B1 deficiency key to vascular problems for diabetic patients
3. Researchers link metal ions to neurodegenerative disease
4. Researchers develop criteria to detect bone mass deficiencies in children with chronic diseases
5. Researchers call for investigation into links between khat use and psychiatric disorders
6. Researchers use MRI to predict recovery after spinal cord injury
7. Researchers find deadly prescription drug effects 6 years before FDA
8. Researchers investigate impact of lifestyle on GI health
9. Researchers begin randomized double-blind trial of airway bypass treatment for emphysema
10. Researchers discover how antibiotic inhibits bacterial growth
11. Researchers urge caution in using ESAs for cancer-related anemia

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/13/2018)... ... ... Pulsara is honored to be represented by its CEO, Dr. James Woodson, ... Chicago. Dr. Woodson, ER Physician and Founder/CEO of Pulsara, has been invited to ... & Collaboration (CC&C) is Not Enough: Why You Need a Regional Communication Network.” , ...
(Date:9/12/2018)... ... , ... Donaldson Plastic Surgery has been included on the Inc. 5000 list ... list of central Ohio's fastest growing businesses. The plastic surgery practice was ranked number ... is the only medical practice and plastic surgery office to make the regional Fast ...
(Date:9/7/2018)... (PRWEB) , ... September 07, 2018 , ... ... Community College District , the only OSHA authorized OTI Education Center headquartered in ... to assist employees who feel they have experienced retaliation in response to engaging ...
(Date:9/2/2018)... (PRWEB) , ... September 02, 2018 , ... ... merges hospitality with positive social change. The hotel itself, which opened this week, ... thought leaders, innovators, lawmakers or more. , Eaton Hotel DC currently features 209 ...
(Date:9/1/2018)... ... 01, 2018 , ... September is Animal Pain Awareness Month, ... (IVAPM) that aims to encourage pain management for all animals through education and ... pet owners of the many forms of pain and the importance of pain ...
Breaking Medicine News(10 mins):
(Date:9/13/2018)... ... 2018 , ... This September is Centers for Disease Control and Prevention’s ... on how to help prevent food poisoning. According to the CDC, every year, an ... and 3,000 die from eating contaminated food. In support of the campaign, Best Sanitizers ...
(Date:9/13/2018)... ... September 13, 2018 , ... NCPDP announced today ... and ensure correct implementation of the NCPDP SCRIPT Standard Version 2017071 ahead of ... and transactions identified by the industry as vital enhancements in improving patient safety, ...
(Date:9/13/2018)... ... September 13, 2018 , ... ... a specialist pharmaceutical company focused on developing and commercializing gastrointestinal therapeutics, has ... product. , The U.S. Food and Drug Administration (FDA) and European Medicines ...
Breaking Medicine Technology:
Cached News: