HOME >> MEDICINE >> NEWS
Researchers identify new therapy for patients with Crohn's disease

ROCHESTER, Minn. -- A study led by Mayo Clinic found that adalimumab (HUMIRA)) is an effective treatment for adults with Crohns disease who do not respond to infliximab (REMICADE) therapy. These findings were published online today by Annals of Internal Medicine.

Crohns disease is an inflammatory disorder of the gastrointestinal tract that affects an estimated 500,000 people in the United States. Symptoms include abdominal pain, fever, nausea, vomiting, weight loss and diarrhea. Crohns disease has no known medical cure. One common therapy is a series of intravenous infusions of infliximab, which blocks tumor necrosis factor, an important cause of inflammation in Crohns disease.

"Approximately 50 percent of Crohns disease patients who receive repeated administration of infliximab will eventually develop an allergic reaction, need higher doses, or completely stop responding to the therapy," says William J. Sandborn, M.D., the lead author and a gastroenterologist at Mayo Clinic. "Our goal with this study was to determine if adalimumab was a safe and effective alternative for these patients."

Like infliximab, adalimumab is a human monoclonal antibody that blocks tumor necrosis factor. However, it is administered via a series of subcutaneous injections, rather than intravenously.

The study included 325 patients at 52 sites with moderate to severe Crohns disease who continued to have symptoms despite infliximab therapy or who could not take infliximab due to an allergic reaction. Researchers found that 21 percent of patients who received adalimumab achieved remission after four weeks, while just 7 percent of patients who received a placebo achieved remission in the same period. Fifty-two percent of patients who received adalimumab achieved an improvement in their clinical symptoms as compared with 34 percent of patients who received a placebo.

"This study demonstrates that in the short term, adalimumab can be safely
'"/>

Contact: Elizabeth Rice
newsbureau@mayo.edu
507-284-5005
Mayo Clinic
1-May-2007


Page: 1 2

Related medicine news :

1. Researchers suggest TB screening for all international adoptees
2. Researchers find vitamin B1 deficiency key to vascular problems for diabetic patients
3. Researchers link metal ions to neurodegenerative disease
4. Researchers develop criteria to detect bone mass deficiencies in children with chronic diseases
5. Researchers call for investigation into links between khat use and psychiatric disorders
6. Researchers use MRI to predict recovery after spinal cord injury
7. Researchers find deadly prescription drug effects 6 years before FDA
8. Researchers investigate impact of lifestyle on GI health
9. Researchers begin randomized double-blind trial of airway bypass treatment for emphysema
10. Researchers discover how antibiotic inhibits bacterial growth
11. Researchers urge caution in using ESAs for cancer-related anemia

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/6/2019)... ... ... Allegheny Health Network (AHN) has named Kymberly Gyure, MD, Chair of the AHN Pathology ... previously served as AHN’s Vice Chair of Pathology and Laboratory Medicine, and Director of ... of the pathology faculty at Drexel University College of Medicine. , Dr. Gyure ...
(Date:12/6/2019)... ... December 06, 2019 , ... Brain Sentinel, ... Baltimore, Maryland at the AES Annual Meeting. The symposium, “Fundamentals of Quantitative Surface ... methods of quantitative sEMG analysis during ictal events;, 2. Review specific sEMG patterns ...
(Date:12/5/2019)... , ... December 05, 2019 , ... ... new, high resolution ultrasound (HRUS) technology to help their patients more easily detect ... MO, is participating in this study and reporting on his experience. While the ...
(Date:12/5/2019)... ... 05, 2019 , ... Intelligent.com, a trusted resource for online ... Programs for 2020. The comprehensive research guide is based on an assessment of ... on curriculum quality, graduation rate, reputation, and post-graduate employment. , The 2020 ...
(Date:12/4/2019)... ... 2019 , ... A November 12 article on NBC Connecticut reported ... options. The article highlighted the life-changing or life-ending consequences of some E-scooter accidents, from ... rider fatality after an incident with a vehicle. Los Angeles-based personal injury law firm ...
Breaking Medicine News(10 mins):
(Date:12/8/2019)... , ... December 08, 2019 , ... A new study ... in the journal Appetite, finds teens overwhelmingly engage with fast food, unhealthy snacks, candy ... Holidays is expected, especially when teens get stuck inside with family members visiting from ...
(Date:12/6/2019)... ... December 06, 2019 , ... Food and nutrition industry ... and ideas about working toward sustainable nutrition security nationwide, increasing accessibility to nutritious ... develop a healthy and sustainable food system,” said Carol May, CEO of Wisdom ...
(Date:12/5/2019)... ... December 05, 2019 , ... LeadingBiotech ,?an exclusive ... announces key issues to be discussed at its East/West CEO conference ... in San Francisco. , Kicking off the week of the J.P. ...
Breaking Medicine Technology:
Cached News: