HOME >> MEDICINE >> NEWS
Researchers link metal ions to neurodegenerative disease

A multi-institutional team of researchers led by Emory University has defined for the first time how metal ions bind to amyloid fibrils in the brain in a way that appears toxic to neurons. Amyloid fibrils are linked to the development of neurodegenerative diseases such as Alzheimer's, Parkinson's and Creutzfeldt-Jakob. Although metal ions, most notably copper, can bind to amyloid in several specific ways, the researchers found that only one way appears toxic.

The findings will appear in the Proceedings of the National Academy of Sciences, Early Edition online during the week of Aug. 6-10 and in the Aug. 14 print edition.

Copper ions, atoms that have acquired an electric charge by gaining or losing one or more electrons, are found naturally in the brain, as are other ions such as zinc and iron. Increasing evidence now links these naturally occurring ions to amyloid assembly and to Alzheimer's disease, says David Lynn, PhD, Emory professor and chair of chemistry and principal investigator of the study.

While little is known about the exact mechanisms governing the formation of amyloid fibrils, the study's results suggest that the exact way amyloid binds to copper ions affects the fibers' architecture, rate of propagation and their effect, if any, on surrounding neurons.

"Not all amyloid fibrils are toxic," says Dr. Lynn. "Amyloid is made of proteins and proteins normally fold into beautiful structures. However, for whatever reason, some misfold and the resulting misfolded structures are also beautiful, but sticky. They stick to themselves and then propagate to form fibrils, but only some of the fibrils turn out to be toxic."

Those who suffer from Alzheimer's disease, for example, have an unusual amount of sticky amyloid fibrils in their brains. Over time, the fibrils accumulate instead of decomposing and increasingly interfere with the brain's structure and function. In contrast, normally folded proteins are clear
'"/>

Contact: Holly Korschun
hkorsch@emory.edu
404-727-3990
Emory University
6-Aug-2007


Page: 1 2 3

Related medicine news :

1. Researchers suggest TB screening for all international adoptees
2. Researchers find vitamin B1 deficiency key to vascular problems for diabetic patients
3. Researchers develop criteria to detect bone mass deficiencies in children with chronic diseases
4. Researchers call for investigation into links between khat use and psychiatric disorders
5. Researchers use MRI to predict recovery after spinal cord injury
6. Researchers find deadly prescription drug effects 6 years before FDA
7. Researchers investigate impact of lifestyle on GI health
8. Researchers begin randomized double-blind trial of airway bypass treatment for emphysema
9. Researchers discover how antibiotic inhibits bacterial growth
10. Researchers urge caution in using ESAs for cancer-related anemia
11. Researchers identify new therapy for patients with Crohns disease

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/16/2019)... Ore. (PRWEB) , ... November 15, 2019 , ... ... older adults living with memory impairment, has announced the Best Memory Care Facilities ... access to experts, facility features and amenities. , According to the ...
(Date:11/16/2019)... ... 15, 2019 , ... As demand for legal medical marijuana ... well-managed dispensaries becomes more and more important, both for consumers and as part ... online, custom cannabis business plans is now increasing its support for marijuana dispensary ...
(Date:11/15/2019)... ... November 15, 2019 , ... ... webinar on comprehensive school physical activity programs (CSPAP) on December 3, 2019 at ... recreation and park professionals, this one-hour and 15-minute webinar will discuss the five ...
(Date:11/14/2019)... TEMECULA, Calif. (PRWEB) , ... November 14, 2019 , ... ... be invited to prepare a gastronomical masterpiece for former President Vicente Fox of Mexico. ... in Leon, Guanajuato, Mexico where President Fox was born and raised on Saturday, November ...
(Date:11/14/2019)... ... November 14, 2019 , ... ... targeted for Roche cobas® and Roche COBAS INTEGRA® analyzers, Order No. 601ro. ... Complement C4 (C4), Immunoglobulin A (IGA), Immunoglobulin G (IGG), Immunoglobulin M (IGM), ...
Breaking Medicine News(10 mins):
(Date:11/16/2019)... ... 15, 2019 , ... MemoryCare.com , a comprehensive resource ... Memory Care Facilities in Columbus, Ohio. The guide identifies 21 memory care communities ... to the Alzheimer’s Association , 5.6 million people age 65 and older ...
(Date:11/16/2019)... ... 15, 2019 , ... October 29 article on WFLA offers ... more than usual is being consumed – is best done near other meal times, ... sugars and acids found in candy are more likely to be neutralized, significantly reducing ...
(Date:11/15/2019)... ... November 15, 2019 , ... JustCBD looks ... Hope For The Warriors was founded by the military families aboard Marine Corps ... on service members and their families. For the past 13 years, Hope For The ...
Breaking Medicine Technology:
Cached News: