HOME >> MEDICINE >> NEWS
Researchers probe enzyme that may lead to new SARS drugs

Researchers at the University of Illinois at Chicago and two other institutions have unraveled the structure of an important new drug target from the virus that causes SARS, severe acute respiratory syndrome.

"By unlocking the three-dimensional structure of this enzyme -- known as papain-like-protease (PLpro) -- we now have a molecular road map to design new drugs that could potentially treat SARS-infected patients, or perhaps patients suffering from other SARS-related illnesses such as the common cold, bronchitis or pneumonia," said Andrew Mesecar, associate professor of pharmaceutical biotechnology in the UIC College of Pharmacy. "We are attempting to use the same approach that has been accomplished in designing effective drugs against HIV protease, which has led to the development of new drugs to fight the AIDS virus."

The research is published in the March 27 issue of the Proceedings of the National Academy of Sciences.

Mesecar said that the knowledge gained from this new atomic structure -- the first-ever reported on this class of proteases -- has the potential to go beyond the treatment of patients infected with the coronavirus that causes SARS.

Coronaviruses, which produce upper respiratory tract infections, were discovered in the late 1960s. The viruses are responsible for 10 percent to 30 percent of all common colds. Recently, two new coronaviruses -- NL63 and HKU1 -- were found to cause many cases of severe pneumonia in children and the elderly throughout the world, he said.

"NL63 and HKU1 infections are severe and often lead to hospitalization," Mesecar said. "It is believed these viruses have been around a long time, but only recently have we developed the technology to identify and detect them. The SARS outbreak and quick response of the scientific community has led to the rapid development of such technology."

SARS was first reported in Asia in early 2003. Over the next several months the illness sp
'"/>

Contact: Sam Hostettler
samhos@uic.edu
312-355-2522
University of Illinois at Chicago
4-Apr-2006


Page: 1 2

Related medicine news :

1. Researchers suggest TB screening for all international adoptees
2. Researchers find vitamin B1 deficiency key to vascular problems for diabetic patients
3. Researchers link metal ions to neurodegenerative disease
4. Researchers develop criteria to detect bone mass deficiencies in children with chronic diseases
5. Researchers call for investigation into links between khat use and psychiatric disorders
6. Researchers use MRI to predict recovery after spinal cord injury
7. Researchers find deadly prescription drug effects 6 years before FDA
8. Researchers investigate impact of lifestyle on GI health
9. Researchers begin randomized double-blind trial of airway bypass treatment for emphysema
10. Researchers discover how antibiotic inhibits bacterial growth
11. Researchers urge caution in using ESAs for cancer-related anemia

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Researchers probe enzyme that may lead new SARS drugs

(Date:3/4/2015)... March 04, 2015 Staff Sgt Shilo ... explosion in Iraq, tells you about the pain and ... free Chiropractic care from the Patriot Project and through ... This is what Harris said in a recent interview, ... clarity, I feel more calm, I'm sleeping better, and ...
(Date:3/4/2015)... i2i Systems Population Health Management ... Brexton Health Care, a 35-year-old Maryland-based community health ... provides comprehensive primary care, behavioral health and dental ... clinics in the greater Baltimore area of Maryland. ... the organization has always focused on providing quality ...
(Date:3/4/2015)... Follow us on LinkedIn ... the increasing incidence of CNS disorders, aging population, rising ... drugs. The unmet medical needs for diagnosing and treating ... the market. Presently, there exists an urgent need for ... of current generation drugs. Companies are therefore investing to ...
(Date:3/4/2015)... Follow us on LinkedIn – ... of the skin and body, are witnessing healthy growth ... to achieve the desired product properties and outcome, cosmetics ... physical beauty, youth, and achievement. Demand for cosmetic chemicals ... cosmetics. Growth in the market is driven by increased ...
(Date:3/4/2015)... Ada Products Company, Inc ., an ... strategic partnership with the Dental Exchange in an effort ... them to engaging, inspiring ideas, products, career opportunities, and ... Dental Exchange is a first-of-its kind online resource ... other social platforms, the Dental Exchange dives much deeper ...
Breaking Medicine News(10 mins):Health News:Decorated Veterans Endorse “Halos for Heroes” an Indiegogo campaign to Help Wounded Military Heal at Home 2Health News:Decorated Veterans Endorse “Halos for Heroes” an Indiegogo campaign to Help Wounded Military Heal at Home 3Health News:Chase Brexton Selects i2i Systems Population Health Management Solutions to Demonstrate HEDIS Quality Outcomes to Maryland’s Health Plans 2Health News:Chase Brexton Selects i2i Systems Population Health Management Solutions to Demonstrate HEDIS Quality Outcomes to Maryland’s Health Plans 3Health News:Rising Incidence of CNS Disorders & a Promising Global Drug Pipeline Drive the CNS Therapeutics Market, According to a New Report by Global Industry Analysts, Inc. 2Health News:Rising Incidence of CNS Disorders & a Promising Global Drug Pipeline Drive the CNS Therapeutics Market, According to a New Report by Global Industry Analysts, Inc. 3Health News:Rising Incidence of CNS Disorders & a Promising Global Drug Pipeline Drive the CNS Therapeutics Market, According to a New Report by Global Industry Analysts, Inc. 4Health News:Rising Demand for Anti-Aging & Skincare Cosmeceuticals to Drive the Global Cosmetic Chemicals Market, According to a New Report by Global Industry Analysts, Inc. 2Health News:Rising Demand for Anti-Aging & Skincare Cosmeceuticals to Drive the Global Cosmetic Chemicals Market, According to a New Report by Global Industry Analysts, Inc. 3Health News:Rising Demand for Anti-Aging & Skincare Cosmeceuticals to Drive the Global Cosmetic Chemicals Market, According to a New Report by Global Industry Analysts, Inc. 4Health News:Ada Products Company, Inc. Announces Strategic Partnership with the Dental Exchange 2
(Date:3/4/2015)... March 4, 2015  KemPharm, Inc., a clinical-stage ... development of proprietary new molecular entity (NME) prodrugs, ... Woody as Chief Commercial Officer.  Ms. Woody ... commercial experience building businesses for both emerging and ... As Chief Commercial Officer, Ms. Woody ...
(Date:3/3/2015)... LUMPUR, Malaysia , March 3, 2015 /PRNewswire/ ... the pharmaceutical market. It not only provides containment ... of handling, and proper delivery. As patent loss ... for packaging will steadily rise, in turn encouraging ... customization is further expected to drive the pharmaceutical ...
(Date:3/3/2015)... 2015 Medical Tracking Solutions, Inc., developers ... of Brian Timberlake as Senior Vice ... and build relationships with existing and new clients. Brian ... sales, and sales management as well as a ... a comprehensive inventory management system that provides real-time ...
Breaking Medicine Technology:KemPharm, Inc. Appoints Tracy M. Woody as Chief Commercial Officer 2Customization is the New Formula in Global Pharmaceutical Packaging, Finds Frost & Sullivan 2Customization is the New Formula in Global Pharmaceutical Packaging, Finds Frost & Sullivan 3Customization is the New Formula in Global Pharmaceutical Packaging, Finds Frost & Sullivan 4Medical Tracking Solutions, Inc. Hires New SVP, Sales 2
Cached News: