HOME >> MEDICINE >> NEWS
Researchers probe enzyme that may lead to new SARS drugs

Researchers at the University of Illinois at Chicago and two other institutions have unraveled the structure of an important new drug target from the virus that causes SARS, severe acute respiratory syndrome.

"By unlocking the three-dimensional structure of this enzyme -- known as papain-like-protease (PLpro) -- we now have a molecular road map to design new drugs that could potentially treat SARS-infected patients, or perhaps patients suffering from other SARS-related illnesses such as the common cold, bronchitis or pneumonia," said Andrew Mesecar, associate professor of pharmaceutical biotechnology in the UIC College of Pharmacy. "We are attempting to use the same approach that has been accomplished in designing effective drugs against HIV protease, which has led to the development of new drugs to fight the AIDS virus."

The research is published in the March 27 issue of the Proceedings of the National Academy of Sciences.

Mesecar said that the knowledge gained from this new atomic structure -- the first-ever reported on this class of proteases -- has the potential to go beyond the treatment of patients infected with the coronavirus that causes SARS.

Coronaviruses, which produce upper respiratory tract infections, were discovered in the late 1960s. The viruses are responsible for 10 percent to 30 percent of all common colds. Recently, two new coronaviruses -- NL63 and HKU1 -- were found to cause many cases of severe pneumonia in children and the elderly throughout the world, he said.

"NL63 and HKU1 infections are severe and often lead to hospitalization," Mesecar said. "It is believed these viruses have been around a long time, but only recently have we developed the technology to identify and detect them. The SARS outbreak and quick response of the scientific community has led to the rapid development of such technology."

SARS was first reported in Asia in early 2003. Over the next several months the illness sp
'"/>

Contact: Sam Hostettler
samhos@uic.edu
312-355-2522
University of Illinois at Chicago
4-Apr-2006


Page: 1 2

Related medicine news :

1. Researchers suggest TB screening for all international adoptees
2. Researchers find vitamin B1 deficiency key to vascular problems for diabetic patients
3. Researchers link metal ions to neurodegenerative disease
4. Researchers develop criteria to detect bone mass deficiencies in children with chronic diseases
5. Researchers call for investigation into links between khat use and psychiatric disorders
6. Researchers use MRI to predict recovery after spinal cord injury
7. Researchers find deadly prescription drug effects 6 years before FDA
8. Researchers investigate impact of lifestyle on GI health
9. Researchers begin randomized double-blind trial of airway bypass treatment for emphysema
10. Researchers discover how antibiotic inhibits bacterial growth
11. Researchers urge caution in using ESAs for cancer-related anemia

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Researchers probe enzyme that may lead new SARS drugs

(Date:11/28/2014)... Based in Minneapolis, MN, Secura Consultants ... exemplary solutions to the income and asset protection markets ... effort to extend its reach across the nation to ... Consultants has brought aboard financial service industry veteran, Matt ... big believer in specialization. When I decided to focus ...
(Date:11/28/2014)... Top10inaction.com, a popular product review and rankings ... For Hair in 2014 at http://top10inaction.com/best-styling-tool-for-hair/ , in ... Featherweight 2 Hair Dryer, ghd Eclipse and Harry Josh ... the significant increase of awareness on women’s beauty, not ... hair styling tools become necessities in women’s daily life. ...
(Date:11/27/2014)... (PRWEB) November 28, 2014 Recently, iFitDress.com, ... added 100 new items to its assortment of ... big discounts, up to 70% off. Some models are ... beautiful discounted black cocktail dresses can enjoy a low ... always have something special for its clients. The business ...
(Date:11/27/2014)... Dallas, TX (PRWEB) November 28, 2014 ... current state of the global Bronchoscopes industry with a ... statistics on the market status of the Bronchoscopes manufacturers ... for companies and individuals interested in the industry. , ... industry including its definition, applications and manufacturing technology. Then, ...
(Date:11/27/2014)... Petersburg, Fl (PRWEB) November 28, 2014 Let ... , Beautiful Christmas boxes with bows on top, filled with ... All prices are deeply discounted today while quantities last - ... . , All products are also available on Amazon at ... found on each Sublime shop product page for ease. , ...
Breaking Medicine News(10 mins):Health News:Matt Lee, CLU, ChFC Joins Secura Consultants as New Brokerage Consultant 2Health News:T3 Featherweight 2 Hair Dryer Is Named As Best Hair Styling Tool 2Health News:Beautiful Black Cocktail Dresses Offered by Top Dress Supplier iFitDress.com 2Health News:Bronchoscopes Industry 2019 Forecasts for Global and China Region in New Research Report at ReportsnReports.com 2Health News:Bronchoscopes Industry 2019 Forecasts for Global and China Region in New Research Report at ReportsnReports.com 3Health News:Big Christmas Sales Begin Today at Sublime Beauty® for all Christmas Gift Selections and Skincare Sets 2
(Date:11/26/2014)... a leader in the development of Chimeric Antigen Receptors ... cancers, today announced the completion of a series A ... -based healthcare private equity fund.   CARsgen ... new therapeutics for liver, lung, stomach and brain cancers. ... Hospital, the company plans to initiate clinical studies for ...
(Date:11/26/2014)... , Nov. 25, 2014  At the American ... this October, KaVo Kerr Group was honored ... Expo, offering attendees the opportunity to see and test ... key opinion leaders deliver lectures on the latest developments ... products include the new DEXIS CariVu Caries Detection Device ...
(Date:11/26/2014)... --  Heska Corporation (NASDAQ: HSKA ) - ... advanced veterinary diagnostic and other specialty veterinary products , ... attend The Benchmark Company, LLC,s Micro Cap Discovery Conference on ... at The Palmer House Hilton, 17 E. Monroe Street, ... p.m. Please email hska@haydenir.com or contact your Benchmark ...
Breaking Medicine Technology:CARsgen Completes Series A Financing 2KaVo Kerr Group Showcased in Pride Institute Technology Expo at ADA Annual Meeting 2KaVo Kerr Group Showcased in Pride Institute Technology Expo at ADA Annual Meeting 3Heska to Attend Benchmark Micro Cap Discovery Conference 2
Cached News: