Researchers show how air pollution can cause hea...( how the neurotransmitters serotonin and...),Health

how the neurotransmitters serotonin and acetylcholine affected the aortic arches of PM2.5-exposed mice differently than those of controls. The arteries taken from exposed mice were less elastic than the control group, constricting more in the presence of serotonin and relaxing less in response to acetylcholine. Once again, the mice fed high-fat diets suffered the most pronounced effects from breathing polluted air.

Finally, the researchers also examined various measures of vascular inflammation, which is involved in atherosclerosis on a number of levels. In the aortas of PM2.5exposed mice, for example, they found increased levels of macrophages, immune cells that are an important ingredient in plaque deposits and also active participants in a biochemical pathway related to inflammation. The study revealed several signs that this pathway was more active, strengthening the connection between airborne particles and cardiovascular disease.

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Contact: Jennifer Choi
jennifer.choi@nyumc.org
212-404-3555
New York University Medical Center and School of Medicine
20-Dec-2005

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