HOME >> MEDICINE >> NEWS
Researchers uncover how prostate cancer cells defy death

Winston-Salem, N.C. -- New findings about how prostate cancer cells are able to resist hormone treatment and defy death may lead to more effective drug treatments, according to researchers from Wake Forest University School of Medicine and colleagues.

"We hope this will lead to new treatments or ways to monitor treatment to make sure it's having its intended effect," said George Kulik, Ph.D., D.V.M., assistant professor of cancer biology and senior researcher.

The goal of the research was to uncover how prostate cancer cells become resistant to treatment that lowers levels of male hormones such as testosterone, which the cells normally need to survive. They found that a protein known as BAD is involved in three different survival strategies used by the cancer cells. Their results are published in the July 28th issue of the Journal of Biological Chemistry.

"The normal response of prostate cells when male hormones are blocked is cell death," said Kulik. "The cancer cells find a way to resist the treatment and we wanted to discover the mechanism."

Treatments for prostate cancer include surgery, radiation therapy and hormone therapy, also known as androgen ablation therapy because it reduces levels of the male hormones that can stimulate the growth certain types of prostate cancer. Lowering hormone levels makes prostate cancer shrink or grow more slowly. It is considered the most efficient systemic therapy for prostate cancer. However, nearly all prostate cancers become resistant to this treatment over time.

The researchers evaluated three different pathways involved in cell signaling, the complex system of communication that governs cell actions. It had previously been shown that three pathways (activated by vasoactive intestinal peptide, epidermal growth factor or phosphoinositide 3-kinase) are known to be involved in cell survival. The goal of the researchers was to learn how these pathways are involved in the can
'"/>

Contact: Karen Richardson
krchrdsn@wfubmc.edu
336-716-4453
Wake Forest University Baptist Medical Center
27-Jul-2006


Page: 1 2

Related medicine news :

1. Researchers suggest TB screening for all international adoptees
2. Researchers find vitamin B1 deficiency key to vascular problems for diabetic patients
3. Researchers link metal ions to neurodegenerative disease
4. Researchers develop criteria to detect bone mass deficiencies in children with chronic diseases
5. Researchers call for investigation into links between khat use and psychiatric disorders
6. Researchers use MRI to predict recovery after spinal cord injury
7. Researchers find deadly prescription drug effects 6 years before FDA
8. Researchers investigate impact of lifestyle on GI health
9. Researchers begin randomized double-blind trial of airway bypass treatment for emphysema
10. Researchers discover how antibiotic inhibits bacterial growth
11. Researchers urge caution in using ESAs for cancer-related anemia

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/21/2019)... ... August 21, 2019 , ... ISOComforter , a leader in providing products for cold ... system starts with a powered cold unit supply that is shaped like a ... with the unit, such as the shoulder pad, lumbar pad, hip wrap, or knee pad. ...
(Date:8/21/2019)... ... August 21, 2019 , ... Future residents got their ... Phase II expansion of Providence Point in Pittsburgh’s Scott Township neighborhood involved additions, ... the 70-unit apartment tower, Hamilton Tower. , The expansion began two ...
(Date:8/19/2019)... (PRWEB) , ... August 19, 2019 , ... ... platform selling Eminence Organic Skin Care products , the authorized retailer will ... Darlene DeVries, was a practicing esthetician in Florida providing Eminence Organic Skin Care ...
(Date:8/19/2019)... ... 2019 , ... ProRehab Louisville and Dr. Stacie Grossfeld have partnered with Louisville ... to top-notch sports medical care and sport injury experts for rehabilitation. , “It ... skating, knows the individualized treatment plan, and understands what a triple toe loop is ...
(Date:8/19/2019)... ... August 19, 2019 , ... A July 26 article ... be brushing their pets’ teeth twice a day. The acknowledges that, with dogs not ... suggests that close monitoring and brushing at least twice a week is likely enough ...
Breaking Medicine News(10 mins):
(Date:8/16/2019)... ... , ... SignatureCare Emergency Center has announced that it is ... Heights, Memorial City, and Bellaire, TX. , The one-day health fair on Tuesday, ... helping Houston families get their children caught up on wellness checks, immunizations and ...
(Date:8/16/2019)... Fla. (PRWEB) , ... August 16, 2019 , ... ... Technology (IT) Innovator, Tricia Lee (Wilkins) Rolle, PharmD, PhD, has joined the company ... will work with public and private sectors and industry standards organizations to advance ...
(Date:8/15/2019)... ... 15, 2019 , ... On Sunday, August 4th, volunteers from Bright Now!® ... difference in the South LA community. Six doctors joined with their dedicated support staff ... , and more at the South Gate Day of Giving. , Over 50 ...
Breaking Medicine Technology:
Cached News: