HOME >> MEDICINE >> NEWS
Researchers urge caution in using ESAs for cancer-related anemia

DURHAM, N.C., April 30 /PRNewswire/ -- Echoing recent FDA warnings, a research group from Northern Ireland cautions against over-aggressive use of a group of drugs called "erythropoiesis-stimulating agents" (ESAs) to treat anemia in some cancer patients, according to a commentary in the April issue of The Oncologist, published by AlphaMed Press.

The article by Dr. Terence R. Lappin and colleagues of Queen's University, Belfast, cites evidence that using ESAs to treat non-chemotherapy-related anemia in cancer patients could increase the risk of death, thromboembolic events, and perhaps even cancer growth. The authors write, "Overall these studies have raised concerns that ESAs could in certain circumstances adversely affect survival in cancer patients and have led to speculation that these agents may enhance thrombosis, tumor growth, and neovascularization."

The ESAs darbepoetin alfa (Aranesp) and epoetin alfa (Epogen and Procrit) are genetically engineered forms of a protein called erythropoietin, which stimulates red blood cell production. The drugs are widely used to treat anemia: low levels of hemoglobin, the oxygen-carrying protein in the blood. They are approved for use in treating anemia in patients with chronic kidney disease and in cancer patients with anemia related to chemotherapy.

However, the FDA has recently issued alerts regarding possible hazards of ESA treatment for anemia in cancer patients not receiving chemotherapy. The alerts were based on problems reported in several studies of such "off-label" use of ESAs. One study showed a 25 percent increase in the risk of death for patients receiving darbepoetin alfa. Another reported that cancer patients treated with ESAs were at much higher risk of abnormal blood clots, or "thromboembolic events" -- including stroke and myocardial infarction.

In their commentary, Dr. Lappin and coauthors draw attention to an additional possibility: that ESAs could promote cancer
'"/>

Contact: George Kendall
gkendall@alphamedpress.com
919-680-0011
AlphaMed Press, Inc.
1-May-2007


Page: 1 2

Related medicine news :

1. Researchers suggest TB screening for all international adoptees
2. Researchers find vitamin B1 deficiency key to vascular problems for diabetic patients
3. Researchers link metal ions to neurodegenerative disease
4. Researchers develop criteria to detect bone mass deficiencies in children with chronic diseases
5. Researchers call for investigation into links between khat use and psychiatric disorders
6. Researchers use MRI to predict recovery after spinal cord injury
7. Researchers find deadly prescription drug effects 6 years before FDA
8. Researchers investigate impact of lifestyle on GI health
9. Researchers begin randomized double-blind trial of airway bypass treatment for emphysema
10. Researchers discover how antibiotic inhibits bacterial growth
11. Researchers identify new therapy for patients with Crohns disease

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/2/2018)... ... August 02, 2018 , ... Mindray, ... 7 Ultrasound system with unique new upgrades at the Society of Vascular Ultrasound ... ZONE Sonography® Technology (ZST), the upgrades include a unique arterial stiffness measurement, which ...
(Date:8/2/2018)... ... August 02, 2018 , ... A new ... topics in acute pain management. In The Role of Acute Care in the ... Engagement Network—an innovative approach to the opioid epidemic launched in the state of ...
(Date:8/2/2018)... ... August 01, 2018 , ... Continuing their momentum in 2018 Sempulse has ... and Chief Investment Officer of Ecliptic Capital, Mike W. Erwin, an early investor in ... have lived in Austin for over 30 years starting companies and investing locally. The ...
(Date:8/2/2018)... MORRISTOWN, N.J. (PRWEB) , ... ... ... Wittig, MD, Orthopedic Oncologist and Sarcoma Surgeon, has been appointed Chairman of ... Orthopedic Oncology at Atlantic Health System, commencing August 1, 2018. ...
(Date:8/1/2018)... and LOS ANGELES (PRWEB) , ... August 01, 2018 , ... ... (MMA) Athlete and two-time UFC Bantamweight Champion TJ Dillashaw have forged a partnership. ... is on the FORBES Top 10 List of CBD Hemp Brands in the country, ...
Breaking Medicine News(10 mins):
(Date:8/9/2018)... ... 2018 , ... Cannabidiol, or CBD, has grabbed national headlines in recent months ... precisely why National Day Calendar collaborated with cbdMD to create a holiday in support ... of National CBD Day after weeks of tireless planning in an effort to bring ...
(Date:8/7/2018)... , ... August 06, 2018 , ... ... gum disease in Clinton, MS using laser dentistry techniques. Using their BIOLASE ... cutting-edge laser gum therapy called REPAIR Perio™. , Affecting the lives of millions ...
(Date:8/7/2018)... ... August 07, 2018 , ... Braun Ambulances is honored to announce ... Bailey Hutchison Convention Center in Dallas, Texas. Braun Ambulances will have four units on ... model. , Fire Rescue International (FRI) is the International Association of Fire Chiefs’ ...
Breaking Medicine Technology:
Cached News: