HOME >> MEDICINE >> NEWS
Retinoblastoma researchers find success with two-drug combination

Investigators at St. Jude Children's Research Hospital have demonstrated in laboratory studies a new treatment for the pediatric eye cancer retinoblastoma that appears to be more effective than the current standard therapy, and more likely to prevent the recurrence of this cancer. A report on their work appears in the October 15 issue of Clinical Cancer Research.

Retinoblastoma is a tumor that arises in the cells of the retina, the light-sensitive tissue at the back of the eyeball, following mutation of the gene RB1. It is the third most common form of cancer in infants. Left untreated, the cancer spreads and is fatal. Retinoblastoma strikes about 250-350 infants and young children each year in the United States.

The St. Jude study suggests a new approach to treatment that could save both lives and vision, according to Michael A. Dyer, PhD, an assistant member of the department of Developmental Neurobiology. The new treatment might also prevent recurrence of retinoblastoma in children whose cancer is very advanced, he noted. Dyer is the senior author of the Clinical Cancer Care report.

The study showed that combination therapy with topotecan and carboplatin is superior to the standard triple-drug therapy using vincristine, carboplatin and etoposide. The new combination eliminates the use of etoposide, which is known to increase the risk of the children getting a form of leukemia called acute myeloblastic leukemia. The findings also suggest that vincristine, which is used in the standard combination therapy, contributes little to the treatment of retinoblastoma, and therefore can be eliminated from therapy.

Dyer's group was prompted to look for new treatments because of the difficulty in managing this cancer. Patients with retinoblastoma usually undergo enucleation (removal of the diseased eye); and children with retinoblastoma in both eyes often must undergo anticancer therapy in order to avoid the loss of both eyes and blindness.

But despi
'"/>

Contact: Kelly Perry
kelly.perry@stjude.org
901-495-3306
St. Jude Children's Research Hospital
17-Oct-2005


Page: 1 2 3

Related medicine news :

1. Stanford researchers find culprit in aging muscles that heal poorly
2. UCLA researchers awarded $9M contract for study identifiying antibiotic treatment for MRSA
3. Penn researchers discover novel pathway for increasing good cholesterol
4. Theory of facial aging gets a facelift from UT Southwestern researchers
5. UIC researchers to develop new drugs to fight bioterrorism
6. UQ researchers discover some of the oldest forms of life
7. U of M researchers discover new method to combat HIV
8. U of M researchers assess effectiveness of computerized physician order entry system
9. Nepalese researchers identify cost-effective treatment for drug-resistant typhoid
10. Physician-researchers often less successful in obtaining NIH funding
11. UCLA researchers develop new nanomaterials to deliver anti-cancer drugs to cells

Post Your Comments:
(Date:4/19/2015)... Lowcostcarinsuranceprice.com has released a new blog ... drivers arrested for DUI. The blog post also discusses ... . , Some pills can have dangerous side ... who are under medication should ask their doctor’s advice ... can be considered driving under the influence and clients ...
(Date:4/19/2015)... Chicago, IL (PRWEB) April 19, 2015 A ... of medical equipment from a major hospital in Brooklyn, NY ... sold including radiology, surgery, endoscopy, lab, anesthesia, exam and much ... 21 and Wednesday, April 22 starting at 9:00am CDT each ... 1400 N. 25th Avenue, Melrose Park, IL 60160. Anyone ...
(Date:4/18/2015)... For some people, tattoos are works of ... rest of their lives, as they have spent a great ... a great amount of thought on their designs. For others, ... them or simply want them removed for personal or professional ... and in 2012-13 there was a 43 percent increase in ...
(Date:4/18/2015)... 18, 2015 Carinsurancehints.com has released a new ... that offer financial protection against fire damage. , ... benefits in case their vehicle is set intentionally on fire. ... by rioting or by other things. , It is ... a single website http://www.carinsurancehints.com/ , in just a ...
(Date:4/18/2015)... Lowcostcarinsuranceprice.com has released a new blog ... auto insurance prices . , Drivers who ... theft may have to pay more for auto insurance ... policies can also offer protection against vehicle theft. ... online on a single website: http://lowcostcarinsuranceprice.com/ . ...
Breaking Medicine News(10 mins):Health News:Driving On Medication - Possible Effects On Auto Insurance Prices 2Health News:Centurion to Sell Surplus Medical Equipment in Online and On-Site Auction 2Health News:Dennis Dass, M.D. is Shattering the Past While Revealing the Future 2Health News:Online Auto Insurance Quotes For Plans That Cover Fire Damages! 2Health News:High Rates Of Car Theft Can Have An Impact on Auto Insurance Prices! 2
(Date:4/17/2015)... --Research and Markets ( http://www.researchandmarkets.com/research/dl9gbg/admetoxicology ) has ... Global Strategic Business Report" report to their offering. ... ADME-Toxicology Testing in US$ Million by the following Segments: ... The report provides separate comprehensive analytics for the ... , Europe , ...
(Date:4/17/2015)... Research and Markets ( http://www.researchandmarkets.com/research/5hkm2f/medical_oxygen ) ... Systems - Global Strategic Business Report" report to ... markets for Medical Oxygen Systems in US$ Thousands by ... Cylinders & Regulators, and Oxygen Conserving Devices. The report ... Canada , Japan , ...
(Date:4/17/2015)... April 17, 2015   IBA Molecular, a ... announced today that it has signed a definitive agreement ... Inc. (IBAM NA), to Illinois Health and Science (IHS). Under ... an independent company headquartered in Dulles, Virginia ... advantage of new product and footprint synergies. IBA Molecular ...
Breaking Medicine Technology:ADME-Toxicology Testing (In-Vivo, & In-Vitro) Market - Global Strategic Business Report 2015: Pharma Industry Renews Focus on Cost Optimization 2Medical Oxygen Systems - 2015 Global Strategic Business Report Featuring Leading Players, Caire, Invacare & Philips Respironics 2Health Care System to Acquire IBA Molecular North America 2Health Care System to Acquire IBA Molecular North America 3
Cached News: