HOME >> MEDICINE >> NEWS
Risk of womb cancer varies according to the type of HRT used

Certain types of hormone-replacement therapy (HRT) increase a woman's risk of womb cancer while others do not, concludes a study published in this week's issue of THE LANCET.

Many post-menopausal women, who have not had a hysterectomy, use combined HRT (containing progestagen and oestrogen) or tibolone (synthetic HRT), because oestrogen-only preparations are known to increase the risk of womb cancer. But little information exists on the incidence of womb cancer in users of these other therapies.

Valerie Beral (Cancer Research UK and University of Oxford) and colleagues recruited 717, 000 postmenopausal women from the UK, aged 50-64 years, who had no previous history of cancer and had not had a hysterectomy, into the Million Women Study, between 1996 and 2001. The women filled in questionnaires about their use of HRT and other personal details and were followed up for an average of 3.4 years. Just under half of the women reported that they had used some form of HRT.1320 womb cancers were diagnosed at follow-up.

The investigators found that, compared with women who had never used HRT, women who last used oestrogen-only HRT or tibolone had a higher risk of womb cancer overall and that the risk increased with longer use of tibolone. By contrast, use of combined HRT did not increase the overall incidence of womb cancer. The researchers also found that among HRT users the risk of womb varied according to bodyweight when compared with women who had never used HRT. In women who were not overweight, a form of HRT, called cyclic-combined HRT, also increased the incidence of womb cancer. In obese women (who normally have a substantially higher incidence of womb cancer than non-obese women), use of both continuous and cyclic combined HRT significantly reduced the incidence of womb cancer, whereas tibolone and oestrogen-only HRT had little additional effect on incidence.

In August 2003, The Lancet published data from the Million Women St
'"/>

Contact: Joe Santangelo
j.santangelo@elsevier.com
1-212-633-3810
Lancet
28-Apr-2005


Page: 1 2

Related medicine news :

1. Conventional prognostic factors fail to explain better prostate cancer survival in most Asian men
2. Survival differences by race most apparent in advanced stages of breast cancer
3. Stomach cancer rate set to fall further 25 percent over next decade
4. MRI finds breast cancer before it becomes dangerous
5. Investigators uncover intriguing clues to why persistent acid reflux sometimes turns into cancer
6. New cause of tamoxifen resistance in breast cancer cells discovered at Lombardi
7. Pathway links inflammation, angiogenesis and breast cancer
8. Using MRI for diagnosis could help prevent breast cancer progression
9. Electric fields have potential as a cancer treatment
10. Shining light on pancreatic cancer
11. Method shows promise for early detection of pancreatic cancer

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/11/2019)... ... 11, 2019 , ... Executives at health systems and hospitals across America are ... over the past several years has been intense. For professionals and organizations that struggle ... America will depend largely on how these executives respond. Will they have the tools ...
(Date:9/11/2019)... ... September 10, 2019 , ... ... facing the ever-changing corporate landscape, Mediaplanet today announces the launch of its ... topics ranging from the importance of candid one-on-one conversations, ideas for improving ...
(Date:9/9/2019)... ... September 09, 2019 , ... ... Dentistry in Cornelius, NC, now welcome individuals with tooth loss in Davidson, NC ... with patients who have single or multiple missing teeth and want the advantages ...
(Date:9/9/2019)... ... September 09, 2019 , ... On September 6, 2019, ... on a diabetes-language movement (#LanguageMatters) to include oral and written language. The organization ... stigma, respectful and inclusive, empowering, and person-centered (to include care that is respectful ...
(Date:9/8/2019)... ... 2019 , ... The Southern Illinois University Edwardsville School of ... reached an all-time high with 1,778 students. , The SON’s enrollment features ... students. The total does not include an additional 30 undeclared graduate students, who ...
Breaking Medicine News(10 mins):
(Date:9/11/2019)... ... 2019 , ... Genedata, the leading provider of enterprise software ... company, has licensed Genedata Biologics® to support their R&D in the areas of ... of our strategy to expand our biopharmaceutical R&D operations, we are implementing Genedata ...
(Date:9/11/2019)... ... September 11, 2019 , ... The ... and cofounder of Viome Naveen Jain, MDLIVE founder Randy Parker, NBC Comcast, senior ... Jay Fulcher. , The 4th Annual Telehealth Secrets conference brings together nationally recognized ...
(Date:9/11/2019)... ... , ... HOLLOWAY AMERICA, a leading manufacturer of stainless steel vessels ... announced it will showcase its problem-solving vessels and tanks at several shows this fall ... will be at ISPE San Diego’s 27th Life Science Resource Fair at the Del ...
Breaking Medicine Technology:
Cached News: