HOME >> MEDICINE >> NEWS
SKCC's Gennadi Glinsky addresses predicting risk in cancer treatment outcome

SAN DIEGO (April 18, 2005) - Sidney Kimmel Cancer Center (SKCC) Associate Professor Gennadi V. Glinsky, M.D., Ph.D., will present an abstract and provide a press briefing on a method for predicting risk in the treatment outcome of cancer patients at the 96th Annual Meeting of the American Association for Cancer Research at the Anaheim Convention Center.

Dr. Glinsky's presentation is scheduled from 2:55 to 3:10 p.m. Sunday, April 17, and the press conference, "Predicting Risk, Treatment and Outcome Based on Genetic Variables," is scheduled from 9 to 9:45 a.m. Tuesday, April 19.

The methods and conclusions of the research are described in the abstract "A Death from Cancer Signature: Microarray Analysis Identifies the 11-gene BMI-1-Pathway Predicting Therapy Failure and Short Survival of Patients Diagnosed with Multiple Types of Cancer."

A research team led by Dr. Glinsky found that the 11-gene signature expression in tumor cells is a consistent, powerful predictor of therapy outcome. Its presence indicates a short interval to disease recurrence, distant metastasis, and death after therapy in cancer patients diagnosed with 10 distinct types of cancer, including prostate, breast, lung, ovarian, bladder, lymphoma and acute myeloid leukemia.

Applying comparative translational genomics, the researchers selected for analysis the 11-gene BMI-1-pathway signature, which is associated with the self-renewal of normal stem cells. What they discovered is that when this pathway is activated in transformed (cancerous) cells, it may contribute to the survival life cycle of cancer stem cells and promotes tumor progression and metastasis.

Thus, when this signature expression is found in tumors, there is a high probability of unfavorable therapy outcome, the researchers concluded. However, if this signature expression is not found in tumor cells, there is a high probability of favorable therapy outcome.

SKCC is in the process of setting
'"/>

Contact: Jay Jeffcoat
jjeffcoat@skccfoundation.org
858-410-4212
Sidney Kimmel Cancer Center
18-Apr-2005


Page: 1 2

Related medicine news :

1. Asia-European collaboration addresses water management in Indonesia
2. New technology addresses female fertility preservation
3. New research addresses taboos around the impact of rheumatoid arthritis on patients sex lives
4. Friedman addresses UN-sponsored African workshop on E-Governance
5. New handbook addresses lesbian, gay, bisexual and transgender health issues
6. UK addresses funding gap created by US anti-abortion stance
7. New pediatrician workforce policy addresses growing challenges in health care
8. Child magazine editor addresses regions first annual womens and childrens health care conference
9. Why predicting the next influenza pandemic is difficult and how scientists can best prepare
10. Repeat bone mineral density scans do not appear helpful for predicting fractures in most older women
11. HIV measurement appears to be less reliable than thought in predicting loss of CD4 cells

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... BASKING RIDGE, N.J. (PRWEB) , ... October 13, 2017 , ... ... second annual Holly Day Market. Featuring a collection of specialty vendors and unique items ... myriad of personalized and quality-focused health and wellness services offered by the VNA. ...
(Date:10/13/2017)... ... 2017 , ... Yisrayl Hawkins, Pastor and Overseer at The House of Yahweh, ... and least understood books in the Holy Scriptures, Revelation. The Book of Revelation paints ... for centuries. Many have tossed it off as mere rubbish, but Yisrayl Hawkins says ...
(Date:10/13/2017)... ... October 13, 2017 , ... “The Journey: From the Mountains to ... to save lost souls in the Philippines. “The Journey: From the Mountains to the ... teacher of the Bible. She has taught all ages and currently teaches a class ...
(Date:10/12/2017)... CA (PRWEB) , ... October 12, 2017 , ... ... Cheng, are now treating sleep apnea using cutting-edge Oventus O2Vent technology. ... a serious sleep disorder characterized by frequent cessation in breathing. Oral appliances can ...
(Date:10/12/2017)... ... October 12, 2017 , ... IsoComforter, Inc. ( https://isocomforter.com ), one ... an innovative new design of the shoulder pad. The shoulder pad provides optimal ... controlling your pain while using cold therapy. By utilizing ice and water that is ...
Breaking Medicine News(10 mins):
(Date:10/5/2017)... Ill. , Oct. 5, 2017  In ... Association of Oral and Maxillofacial Surgeons (AAOMS) released ... opioids – to be used as a first-line ... pain. Recognizing ... the AAOMS White Paper "Opioid Prescribing: Acute and ...
(Date:10/2/2017)... 2017 Diplomat Pharmacy, Inc. (NYSE: ... Consulting, LLC , and named its founder as Diplomat,s ... Tennessee , will operate under Diplomat ... service offerings for health care partners to include IT ... "In an interoperable world, technology delivers comprehensive ...
(Date:10/2/2017)... -- The Rebound mobile app is poised to become a ... of prescription drug addiction. The app empowers users to develop ... down their dosage in a safe, controlled manner while maximizing ... first 100,000 people to sign up will enjoy 3 months ... ...
Breaking Medicine Technology:
Cached News: