Scans may help pin down tricky diagnosis

(BETHESDA, MD) A type of scintigraphy scan may help clinicians properly diagnose and then treat two forms of cardiac amyloidosis, a rare type of heart failure caused by abnormal protein deposition in the heart, according to a new study in the Sept. 20, 2005, issue of the Journal of the American College of Cardiology.

"Clinically, this finding helps differential diagnosis and reduces the risk of misdiagnosis between two conditions with very different therapeutic options," said Claudio Rapezzi, M.D. from the University of Bologna and S. Orsola-Malpighi Hospital in Bologna, Italy.

Clinicians have a difficult time distinguishing between transthyretin amyloidosis, which is often hereditary, and acquired monoclonal immunoglobulin light-chain amyloidosis, which is often a consequence of multiple myeloma. Although the two forms of abnormal protein deposition look similar and both stiffen the heart muscle, ultimately leading to heart failure; they require different treatments. Treatment of transthyretin amyloidosis can include liver transplantation, while bone marrow transplantation may be indicated for acquired monoclonal immunoglobulin light-chain amyloidosis.

This small trial is the first assessment of scintigraphy in patients with cardiac amyloidosis. Intravenous solutions containing a radioactive isotope (99mTc-DPD) were given to 15 patients with transthyretin amyloidosis and 10 patients with acquired monoclonal immunoglobulin light-chain amyloidosis. Genotyping and immunohistochemistry were used as the reference standards for this study.

Detectors showed that the radioactive tracer was taken up by the heart muscle tissue of the transthyretin amyloidosis patients, but not by the hearts of the patients with acquired monoclonal immunoglobulin light-chain amyloidosis.

"From a research perspective, the study also indicates that etiology, the cause of a disease, is a third major cause, in addition to type of organ involved and tracer

Contact: Anne Dees
American College of Cardiology

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