HOME >> MEDICINE >> NEWS
Scent prediction

This release is also available in German.

The scent of lily of the valley hangs in the air for readers of the journal Angewandte Chemie: just rub the journal's cover and enjoy a lily-of-the-valley scent. Lily-of-the-valley scent components can also be found within the pages of the journal: an interdisciplinary team headed by Reinhold Tacke (Inorganic Chemistry, University of Wrzburg), Philip Kraft (Scent Research, Givaudan Schweiz Inc.), and Hanns Hatt (Cell Biology, University of Bochum) have attempted a "scent prediction" to test their computer model of lily-of-the-valley fragrance receptor hOR17-4. This molecule was characterized in detail as the first human scent receptor by Hatt and his co-workers, who also discovered it in sperm.

A fragrance is usually composed of a mixture of many different scented substances. Each of these individual substances can react with several of the approximately 347 scent receptors in our nose and show a complex scent. "When developing new fragrances, we have to rely on correlations between structure and effect derived from model substances as well as intuition," says Kraft. With the help of sperm, however, it is possible to study the lily-of-the-valley receptor in virtual isolation and simulate the primary process of scent sensing by computer.

An olfactory receptor responds to a scent molecule when it fits into the receptor's binding cavity. If the structure of the cavity is known, it should be possible to use computer models to predict whether a scent activates the receptor in question and to what degree. To prove this theory, the scientists investigated how the replacement of one carbon atom with a silicon atom affects the scent of lily-of-the-valley fragrance components lilial and bourgeonal, and whether this subtle alteration, which has minimal influence on the molecular shape, can also be predicted quantitatively. The
'"/>

Contact: Reinhold Tacke
r.tacke@mail.uni-wuerzburg.de
49-931-888-5250
John Wiley & Sons, Inc.
18-Apr-2007


Page: 1 2

Related medicine news :

1. Scent of fear impacts cognitive performance
2. Newer biomarkers add small improvement in cardiovascular risk prediction to established risk factors
3. Genomic tests improve prediction of breast cancer response to chemotherapy, hormonal therapy
4. Hopkins researchers identify risk factors for prediction of lethal prostate cancer after recurrence

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/21/2017)... ... January 21, 2017 , ... Pacifica Graduate Institute’s Alumni ... line-up of events for its annual meeting “Coming Home 2017,” an activity-packed weekend ... Home 2017” will be held on Friday January 27 through Sunday, January 29, ...
(Date:1/21/2017)... ... January 21, 2017 , ... The Nobel Biocare™ ... Holtzclaw in media for its creos™ line of bone regenerative products. Specifically, ... in which he utilizes creos™ allo.gain™ bone graft for a variety of bone ...
(Date:1/20/2017)... ... ... Source Vitál Apothecary, a skin and body care company dedicated to creating ... a successful visit to the 2017 ECRM Diet, Vitamin & Sports Nutrition Conference in ... nutritional, sports and health industries a chance to meet in private sessions with some ...
(Date:1/20/2017)... ... January 20, 2017 , ... ATP ... people’s everyday lives, recently attended the January ECRM Trade Show in Hilton Head, ... known for its large range of supplements that keep the body functioning at ...
(Date:1/20/2017)... York, NY (PRWEB) , ... January 20, 2017 ... ... – VW+ 001 and its sugar-free alternative VW+ 002. The drinks have been ... body with optimal conditions to perform during your workout. , After a successful ...
Breaking Medicine News(10 mins):
(Date:1/19/2017)... -- Conference Call and Webcast to Follow Vanda Pharmaceuticals ... release results for the fourth quarter of 2016 on Wednesday, February ... ... 4:30 PM ET on Wednesday, February 15, 2017, during which management ... and other corporate activities. To participate in the conference call, please ...
(Date:1/19/2017)... 19, 2017 This report on the opioid ... scenario of the global market. Large number of chronic ... chronic constipation is a major side effect of consumption ... novel targeted therapy has been prescribed to treat opioid ... targeted medicines, and growing awareness about the therapy are ...
(Date:1/19/2017)... 2017  Stealth BioTherapeutics Inc. ( Stealth ), a ... today announced new additions to its senior leadership team: ... Officer, and Daniel Geffken as interim Chief ... Carr , Pharm.D. has been promoted to Chief Clinical ... welcome Doug and Daniel to our management team, as ...
Breaking Medicine Technology:
Cached News: