HOME >> MEDICINE >> NEWS
Scientists develop method to remove prion infectivity from scrapie-infected blood

Scientists have developed a device that can remove disease-causing prions from scrapie-infected animal blood. They report their development in Article in this week's issue of The Lancet.

Prion diseases, such as sheep scrapie, bovine spongiform encephalopathy (BSE), and variant Creutzfeldt-Jakob disease (vCJD) in humans, are fatal neurodegenerative diseases that occur after years of incubation with no apparent symptoms. So far in the UK, three people have died from vCJD after receiving blood from donors who later went on to develop the disease. Selectively removing prion infectivity from donated blood might be one of the best ways of reducing the risk of transmission.

Robert Rohwer and colleagues screened millions of molecules to find one, called L13 that selectively binds the prion protein (PrP). To test its binding ability, the investigators first passed 500 mL of scrapie-infected hamster blood through a filter that removes white blood cells*. When they injected the white blood cell depleted blood into 99 hamsters, 15 became infected with scrapie. However, when they next passed the white blood cell depleted blood through devices containing the removal molecule and injected 96 hamsters with it, they found that none became infected. The researchers also found that L13 could selectively bind to PrP from human infections of vCJD, suggesting that it may also remove prion infectivity from human blood.

Dr Rohwer (Veterans Affairs Medical Center, at the University of Maryland, Baltimore, MD, USA) states: "Removal of vCJD infectivity by adsorption gets around the extremely difficult problem of detecting the very low concentrations of these agents in blood, especially during the long asymptomatic period of the disease when people donate. For these disease agents removal may be our best and perhaps our only option." (Quote by e-mail; does not appear in published paper)

See also accompanying Comment.


'"/>

Contact: Joe Santangelo
j.santangelo@elsevier.com
212-633-3810
Lancet
21-Dec-2006


Page: 1

Related medicine news :

1. Scientists train nano-building blocks to take on new shapes, as reported in Science
2. Scientists find war vets hand dexterity determines susceptibility to PTSD
3. Scientists develop method to track immune system enzyme in live animals
4. Scientists from the CIMA investigate a molecule for diagnosing hypertensive cardiopathy
5. Scientists equip bacteria with custom chemo-navigational system
6. Scientists find missing link to understand how plants make vitamin C
7. Scientists and polar explorers brave the elements in support of CryoSat-2
8. Scientists identify cells responsible for relapse after treatment in common childhood cancer
9. Scientists progress in successful tissue engineering
10. Scientists re-grow dental enamel from cultured cells
11. Scientists create dual-modality microbeads to improve identification of disease biomarkers

Post Your Comments:
(Date:8/27/2015)... Costa Mesa, CA (PRWEB) , ... August 27, 2015 , ... ... in to get help, leaving weeks or months later, relapsing and returning again, all ... accidents under the influence while in sober living homes or soon after leaving facilities ...
(Date:8/27/2015)... ... August 27, 2015 , ... Workflow ... quantitative PCR (qPCR) in the last decade. New features such as ... costs. On the flipside, where do lab managers, technicians, and researchers find handy ...
(Date:8/27/2015)... Los Angeles, CA (PRWEB) , ... August 27, 2015 , ... ... Diabetes Association and the American Heart Association have released new guidelines to educate doctors ... that the last update to these particular guidelines came in 2007, so the new ...
(Date:8/27/2015)... ... ... Thriveology Founders, Dr. Carly Letzt Carney and Dr. Mark Carney announced today that ... on Saturday, August 29, 2015 at the Marriott DTC, 4900 S. Syracuse Street, Denver, ... will present a two part seminar entitled, “How to Thrive as You Age & ...
(Date:8/27/2015)... ... August 27, 2015 , ... In mid-May, ... marijuana industry with the launch of its Doobster platform, a HIPAA-compliant mobile application ... products from their smart phones and tablets. Well, Doobster, “The App That ...
Breaking Medicine News(10 mins):Health News:National Screenings of Documentary Indicate Burgeoning Questions about the Effectiveness of Addiction Treatment Facilities 2Health News:National Screenings of Documentary Indicate Burgeoning Questions about the Effectiveness of Addiction Treatment Facilities 3Health News:Douglas Scientific® Webinar Outlines Comparisons of Varied qPCR Instruments 2Health News:Douglas Scientific® Webinar Outlines Comparisons of Varied qPCR Instruments 3Health News:Article on New Diabetic Care Guidelines Shines Brightly on Weight Loss Surgery, notes Beverly Hills Physicians 2Health News:Article on New Diabetic Care Guidelines Shines Brightly on Weight Loss Surgery, notes Beverly Hills Physicians 3Health News:Internationally-renowned Naturopathic Doctor and Chiropractor Team up to Reveal Secrets of Avoiding Disease 2Health News:Doobster Launches a Nationwide, Comprehensive On-Demand Medical Marijuana App 2Health News:Doobster Launches a Nationwide, Comprehensive On-Demand Medical Marijuana App 3Health News:Doobster Launches a Nationwide, Comprehensive On-Demand Medical Marijuana App 4Health News:Doobster Launches a Nationwide, Comprehensive On-Demand Medical Marijuana App 5
(Date:8/27/2015)... 2015  Mytrus, a technology and services company revolutionizing clinical trials, ... consent has received approval for use by ... the first time e-Consent technology will be used in ... Mytrus was also the first electronic informed ... by the U.S. Food and Drug Administration in 2011. ...
(Date:8/27/2015)... , Aug. 27, 2015  Lightwave Logic, ... the development of Next Generation Photonic Devices ... applications in high speed fiber-optic data communications and ... Lebby has been appointed to the Company,s ... in the field of optoelectronics is widely recognized ...
(Date:8/27/2015)... 2015 WuXi PharmaTech (Cayman) Inc. (NYSE:  WX), a ... company serving the pharmaceutical, biotechnology, and medical ... and manufacturing subsidiary Shanghai SynTheAll Pharmaceutical Co., ... the Japan PMDA for the manufacture of ... drug in July. STA is now the ...
Breaking Medicine Technology:Britain's National Health Service Approves The Use Of Mytrus Technology For Electronic Informed Consent In Clinical Trials 2Britain's National Health Service Approves The Use Of Mytrus Technology For Electronic Informed Consent In Clinical Trials 3Britain's National Health Service Approves The Use Of Mytrus Technology For Electronic Informed Consent In Clinical Trials 4Britain's National Health Service Approves The Use Of Mytrus Technology For Electronic Informed Consent In Clinical Trials 5Britain's National Health Service Approves The Use Of Mytrus Technology For Electronic Informed Consent In Clinical Trials 6Britain's National Health Service Approves The Use Of Mytrus Technology For Electronic Informed Consent In Clinical Trials 7Lightwave Logic Announces the Appointment of Optoelectronics Industry Leader, Michael Lebby, Ph.D. to its Board of Directors 2Lightwave Logic Announces the Appointment of Optoelectronics Industry Leader, Michael Lebby, Ph.D. to its Board of Directors 3WuXi PharmaTech's STA Subsidiary Receives First Approval from Japanese Regulatory Authorities 2
Cached News: