HOME >> MEDICINE >> NEWS
Scientists develop method to remove prion infectivity from scrapie-infected blood

Scientists have developed a device that can remove disease-causing prions from scrapie-infected animal blood. They report their development in Article in this week's issue of The Lancet.

Prion diseases, such as sheep scrapie, bovine spongiform encephalopathy (BSE), and variant Creutzfeldt-Jakob disease (vCJD) in humans, are fatal neurodegenerative diseases that occur after years of incubation with no apparent symptoms. So far in the UK, three people have died from vCJD after receiving blood from donors who later went on to develop the disease. Selectively removing prion infectivity from donated blood might be one of the best ways of reducing the risk of transmission.

Robert Rohwer and colleagues screened millions of molecules to find one, called L13 that selectively binds the prion protein (PrP). To test its binding ability, the investigators first passed 500 mL of scrapie-infected hamster blood through a filter that removes white blood cells*. When they injected the white blood cell depleted blood into 99 hamsters, 15 became infected with scrapie. However, when they next passed the white blood cell depleted blood through devices containing the removal molecule and injected 96 hamsters with it, they found that none became infected. The researchers also found that L13 could selectively bind to PrP from human infections of vCJD, suggesting that it may also remove prion infectivity from human blood.

Dr Rohwer (Veterans Affairs Medical Center, at the University of Maryland, Baltimore, MD, USA) states: "Removal of vCJD infectivity by adsorption gets around the extremely difficult problem of detecting the very low concentrations of these agents in blood, especially during the long asymptomatic period of the disease when people donate. For these disease agents removal may be our best and perhaps our only option." (Quote by e-mail; does not appear in published paper)

See also accompanying Comment.


'"/>

Contact: Joe Santangelo
j.santangelo@elsevier.com
212-633-3810
Lancet
21-Dec-2006


Page: 1

Related medicine news :

1. Scientists train nano-building blocks to take on new shapes, as reported in Science
2. Scientists find war vets hand dexterity determines susceptibility to PTSD
3. Scientists develop method to track immune system enzyme in live animals
4. Scientists from the CIMA investigate a molecule for diagnosing hypertensive cardiopathy
5. Scientists equip bacteria with custom chemo-navigational system
6. Scientists find missing link to understand how plants make vitamin C
7. Scientists and polar explorers brave the elements in support of CryoSat-2
8. Scientists identify cells responsible for relapse after treatment in common childhood cancer
9. Scientists progress in successful tissue engineering
10. Scientists re-grow dental enamel from cultured cells
11. Scientists create dual-modality microbeads to improve identification of disease biomarkers

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/22/2017)... ... January 22, 2017 , ... Zifam Pinnacle, an Australian ... world, recently met with big-name retail buyers at the January ECRM Trade Show in ... and uses the utmost safety standards in all of its creations to help create ...
(Date:1/22/2017)... ... January 22, 2017 , ... Medical lab testing ... the results of a simple test will take days to arrive to the end ... offers customers direct access to their lab tests, bypassing the cost and delay of ...
(Date:1/21/2017)... ... 21, 2017 , ... Salveo for life, a company that distributes an effervescent ... United States as part of its presence to expand its market reach. , Using ... the productions of nasty toxins as a result of drinking alcohol, eliminating those toxins ...
(Date:1/21/2017)... ... January 21, 2017 , ... Seamild, the largest manufacturer of ... vision of its owner and founder. As Oat is recognized globally as one of ... knows personally as he believes it is a move to sow the seed of ...
(Date:1/21/2017)... ... January 21, 2017 , ... Pacifica Graduate Institute’s Alumni ... line-up of events for its annual meeting “Coming Home 2017,” an activity-packed weekend ... Home 2017” will be held on Friday January 27 through Sunday, January 29, ...
Breaking Medicine News(10 mins):
(Date:1/19/2017)... ATLANTIC CITY, N.J. , Jan. 19, 2017 /PRNewswire/ ... paying over $100 for their medication when a pharmacy ... the same exact prescription.  To alleviate this problem ... doctors and patients to see exactly how much their ... Comparison Shopping Made Easy ...
(Date:1/19/2017)... SUNNYVALE, Calif. , Jan. 19, 2017 ... that its CyberKnife® and TomoTherapy® Systems continue to set ... systems received the highest composite overall user satisfaction rating ... to the Q4 2016 MD Buyline Market Intelligence Briefing™. ... achieved the highest composite ratings among industry peers for ...
(Date:1/19/2017)... 2017 ViewRay, Inc. (Nasdaq: VRAY) announced today that ... research in Germany , has purchased ... the University Clinic Heidelberg as part of its initiative ... program will be headed by Medical Director and Professor ... at the German Cancer Research Center (DKFZ), the Heidelberg ...
Breaking Medicine Technology:
Cached News: