HOME >> MEDICINE >> NEWS
Scientists develop method to remove prion infectivity from scrapie-infected blood

Scientists have developed a device that can remove disease-causing prions from scrapie-infected animal blood. They report their development in Article in this week's issue of The Lancet.

Prion diseases, such as sheep scrapie, bovine spongiform encephalopathy (BSE), and variant Creutzfeldt-Jakob disease (vCJD) in humans, are fatal neurodegenerative diseases that occur after years of incubation with no apparent symptoms. So far in the UK, three people have died from vCJD after receiving blood from donors who later went on to develop the disease. Selectively removing prion infectivity from donated blood might be one of the best ways of reducing the risk of transmission.

Robert Rohwer and colleagues screened millions of molecules to find one, called L13 that selectively binds the prion protein (PrP). To test its binding ability, the investigators first passed 500 mL of scrapie-infected hamster blood through a filter that removes white blood cells*. When they injected the white blood cell depleted blood into 99 hamsters, 15 became infected with scrapie. However, when they next passed the white blood cell depleted blood through devices containing the removal molecule and injected 96 hamsters with it, they found that none became infected. The researchers also found that L13 could selectively bind to PrP from human infections of vCJD, suggesting that it may also remove prion infectivity from human blood.

Dr Rohwer (Veterans Affairs Medical Center, at the University of Maryland, Baltimore, MD, USA) states: "Removal of vCJD infectivity by adsorption gets around the extremely difficult problem of detecting the very low concentrations of these agents in blood, especially during the long asymptomatic period of the disease when people donate. For these disease agents removal may be our best and perhaps our only option." (Quote by e-mail; does not appear in published paper)

See also accompanying Comment.


'"/>

Contact: Joe Santangelo
j.santangelo@elsevier.com
212-633-3810
Lancet
21-Dec-2006


Page: 1

Related medicine news :

1. Scientists train nano-building blocks to take on new shapes, as reported in Science
2. Scientists find war vets hand dexterity determines susceptibility to PTSD
3. Scientists develop method to track immune system enzyme in live animals
4. Scientists from the CIMA investigate a molecule for diagnosing hypertensive cardiopathy
5. Scientists equip bacteria with custom chemo-navigational system
6. Scientists find missing link to understand how plants make vitamin C
7. Scientists and polar explorers brave the elements in support of CryoSat-2
8. Scientists identify cells responsible for relapse after treatment in common childhood cancer
9. Scientists progress in successful tissue engineering
10. Scientists re-grow dental enamel from cultured cells
11. Scientists create dual-modality microbeads to improve identification of disease biomarkers

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/23/2017)... ... , ... 21 Middle East and South Asia Leaders Selected as Eisenhower Fellows ... and civil society in 11 countries across the Middle East and South Asia to ... exchange of knowledge and ideas with the leading minds in their fields. , ...
(Date:6/23/2017)... , ... June 23, 2017 , ... PureLife Dental is ... amalgam separator supplier for CDA members. As part of the amalgam separator endorsement, all ... $99, saving more than $400 off the retail value. This partnership between PureLife and ...
(Date:6/23/2017)... Jupiter, FL (PRWEB) , ... June 23, 2017 , ... ... the award winning series, which is slated to air fourth quarter 2017. American Farmer ... Christian D.A. Hansen, a Danish pharmacist, founded Chr. Hansen in Denmark in 1874 ...
(Date:6/23/2017)... ... June 23, 2017 , ... The Katyl Agency, a ... families and business owners in and around Lackawanna County, is joining Meals On ... the area. , Meals on Wheels of NEPA provides hand-delivered and nutritious meals ...
(Date:6/23/2017)... ... June 23, 2017 , ... All-Star Insurance, a family managed ... clients throughout eastern Texas, is announcing the launch of a new charity drive to ... statistics in the United States reveal that an estimated 252, 710 new cases of ...
Breaking Medicine News(10 mins):
(Date:6/9/2017)... ALTO, Calif. , June 9, 2017 ... device company focused on the design, manufacture, sale and ... the market on the progress of its commercial roll-out ... is now available in more than one hundred (100) ... AeroForm offers a needle-free alternative for ...
(Date:6/8/2017)... , June 8, 2017  Less than a ... hit more than 200,000 companies, including hospital networks, in ... heralded as one of the largest online extortion attempts ... the healthcare market, it is imperative that providers understand ... their data from this — and many other very ...
(Date:6/8/2017)... 8, 2017  StatLab Medical Products ("StatLab" ... manufacturer of diagnostic supplies for the anatomic ... & Company LP ("Cressey & Company"), a ... growth-focused investment in the Company. Cressey & ... from selling shareholder, Prairie Capital, L.P., with ...
Breaking Medicine Technology:
Cached News: