HOME >> MEDICINE >> NEWS
Scientists find missing link to understand how plants make vitamin C

Hanover, NH--Vitamin C is possibly the most important small molecule whose biosynthetic pathway remained a mystery. That is until now.

A group of Dartmouth and UCLA researchers, who normally work on genes involved in aging and cancer in animals, discovered the last piece of the puzzle, they report in a study published online April 26 in the Journal of Biological Chemistry.

Dr. Steven Clarke of the UCLA Molecular Biology Institute and the Department of Chemistry and Biochemistry explains, We were working on an interesting gene in worms. One insight led to another until, We uncovered the last unknown enzyme in the synthesis of vitamin C in plants, said Dr. Charles Brenner of Dartmouth Medical Schools Norris Cotton Cancer Center and Department of Genetics.

An essential vitamin for people, vitamin C is well known as an antioxidant and enzyme cofactor. Humans lost the ability to make vitamin C and need to take it up from dietary sources, particularly from plants.

Only in 1998 was a biosynthetic pathway proposed to explain how plants make vitamin C. Research since then has confirmed much of the pathway, although the gene responsible for the seventh step of the proposed 10-step pathway from glucose to vitamin C remained unknown.

The work began in an effort to understand the role of a gene in C. elegans, a tiny worm used as a model for aging studies by researcher Tara Gomez in Clarkes UCLA laboratory. The sequence of the gene suggested that it is related to a family of genes altered in cancer, termed HIT genes, that Brenner studies at Dartmouth.

Collaboration between the two laboratories revealed similarity of the worm gene to the product of the VTC2 gene of Arabidopis thaliana, a small roadside plant whose genetics have been well studied. Mutations in this plant gene had been previously linked to low levels of vitamin C. So the hunt was on to determine how its product would contribute to vitamin C s
'"/>

Contact: Hali Wickner
Hali.Wickner@Dartmouth.EDU
603-650-1492
Dartmouth Medical School
27-Apr-2007


Page: 1 2

Related medicine news :

1. Scientists train nano-building blocks to take on new shapes, as reported in Science
2. Scientists find war vets hand dexterity determines susceptibility to PTSD
3. Scientists develop method to track immune system enzyme in live animals
4. Scientists from the CIMA investigate a molecule for diagnosing hypertensive cardiopathy
5. Scientists equip bacteria with custom chemo-navigational system
6. Scientists and polar explorers brave the elements in support of CryoSat-2
7. Scientists identify cells responsible for relapse after treatment in common childhood cancer
8. Scientists progress in successful tissue engineering
9. Scientists re-grow dental enamel from cultured cells
10. Scientists create dual-modality microbeads to improve identification of disease biomarkers
11. Scientists develop method to remove prion infectivity from scrapie-infected blood

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... ... October 13, 2017 , ... Lori R. Somekh, founder of the ... national organization of elder law and special needs planning attorneys. “Membership in ElderCounsel helps ... provides a forum to network with elder law attorneys nationwide,” said Somekh. , ...
(Date:10/13/2017)... ... 2017 , ... Many families have long-term insurance that covers care for a ... waiver for care if the client has a cognitive impairment diagnosis. , “What ... is often waived, so the benefits from their insurance start immediately,” said Mechell Vieira, ...
(Date:10/13/2017)... York, NY (PRWEB) , ... October 13, 2017 , ... ... influential people in business to advocate for action towards gender equality at their inaugural ... views from around the globe, and reached a social audience of over 3 million. ...
(Date:10/13/2017)... ... 13, 2017 , ... Yisrayl Hawkins, Pastor and Overseer at The House of ... popular and least understood books in the Holy Scriptures, Revelation. The Book of Revelation ... scholars for centuries. Many have tossed it off as mere rubbish, but Yisrayl Hawkins ...
(Date:10/13/2017)... ... October 13, 2017 , ... ... Software Development, has been awarded a contract by the Center for Medicare and ... aims to accelerate the enterprise use of Agile methodologies in a consistent and ...
Breaking Medicine News(10 mins):
(Date:10/10/2017)... received FDA 510(k) clearance in May 2017 for its highly anticipated ... for endoscopy environments. An innovative secondary monitor solution, ZeroWire Mobile ... the improvement of patient outcomes, procedural efficiency, and the lowering of ... ... By ...
(Date:10/7/2017)... 6, 2017   Provista, a proven leader ... billion in purchasing power, today announced a new resource ... The Newsroom is the online home for case ... expert bios, news releases, slideshows and events. ... wealth of resources at their fingertips, viewers can also ...
(Date:10/4/2017)... , Oct. 4, 2017  South Korean-based healthcare product ... training aide "cprCUBE" on Kickstarter. The device will educate ... cardiac arrests with better efficiency compared to the dated ... real-time feedback on efficacy of the compression for a ... has a goal to raise $5,000. ...
Breaking Medicine Technology:
Cached News: