HOME >> MEDICINE >> NEWS
Scientists find missing link to understand how plants make vitamin C

Hanover, NH--Vitamin C is possibly the most important small molecule whose biosynthetic pathway remained a mystery. That is until now.

A group of Dartmouth and UCLA researchers, who normally work on genes involved in aging and cancer in animals, discovered the last piece of the puzzle, they report in a study published online April 26 in the Journal of Biological Chemistry.

Dr. Steven Clarke of the UCLA Molecular Biology Institute and the Department of Chemistry and Biochemistry explains, We were working on an interesting gene in worms. One insight led to another until, We uncovered the last unknown enzyme in the synthesis of vitamin C in plants, said Dr. Charles Brenner of Dartmouth Medical Schools Norris Cotton Cancer Center and Department of Genetics.

An essential vitamin for people, vitamin C is well known as an antioxidant and enzyme cofactor. Humans lost the ability to make vitamin C and need to take it up from dietary sources, particularly from plants.

Only in 1998 was a biosynthetic pathway proposed to explain how plants make vitamin C. Research since then has confirmed much of the pathway, although the gene responsible for the seventh step of the proposed 10-step pathway from glucose to vitamin C remained unknown.

The work began in an effort to understand the role of a gene in C. elegans, a tiny worm used as a model for aging studies by researcher Tara Gomez in Clarkes UCLA laboratory. The sequence of the gene suggested that it is related to a family of genes altered in cancer, termed HIT genes, that Brenner studies at Dartmouth.

Collaboration between the two laboratories revealed similarity of the worm gene to the product of the VTC2 gene of Arabidopis thaliana, a small roadside plant whose genetics have been well studied. Mutations in this plant gene had been previously linked to low levels of vitamin C. So the hunt was on to determine how its product would contribute to vitamin C s
'"/>

Contact: Hali Wickner
Hali.Wickner@Dartmouth.EDU
603-650-1492
Dartmouth Medical School
27-Apr-2007


Page: 1 2

Related medicine news :

1. Scientists train nano-building blocks to take on new shapes, as reported in Science
2. Scientists find war vets hand dexterity determines susceptibility to PTSD
3. Scientists develop method to track immune system enzyme in live animals
4. Scientists from the CIMA investigate a molecule for diagnosing hypertensive cardiopathy
5. Scientists equip bacteria with custom chemo-navigational system
6. Scientists and polar explorers brave the elements in support of CryoSat-2
7. Scientists identify cells responsible for relapse after treatment in common childhood cancer
8. Scientists progress in successful tissue engineering
9. Scientists re-grow dental enamel from cultured cells
10. Scientists create dual-modality microbeads to improve identification of disease biomarkers
11. Scientists develop method to remove prion infectivity from scrapie-infected blood

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/13/2019)... (PRWEB) , ... February 13, 2019 , ... With Valentine’s ... sexually transmitted disease (STD) testing service, is sharing 7 tips to ensure ‘Safe Sex’: ... especially if you’re going to engage in safe sex. Having clear, open, and honest ...
(Date:2/13/2019)... , ... February 13, 2019 , ... Infertility is an issue for 1 in 6 ... A startling 2017 study outlining the sharp decline in male sperm count over the last ... , garnering worldwide attention and causing panic that we are in the midst of a ...
(Date:2/13/2019)... Ill. (PRWEB) , ... February 13, 2019 , ... Surgery ... significantly effective and safe treatment for obstructive sleep apnea (OSA), resulting in benefits that ... cardiovascular risk, according to a new study. , MMA should be regarded as the ...
(Date:2/12/2019)... ... February 12, 2019 , ... ... consulting organization, devoted to helping hospital leaders, staff, and physicians achieve excellence, ... . The website now features a streamlined design, improved functionality, and robust ...
(Date:2/12/2019)... ... February 12, 2019 , ... Surgical Theater is ... satisfaction, improve patient retention, and reduce patient outmigration for attendees of the Healthcare ... provides Surgical Theater with a great venue to highlight the value of patient ...
Breaking Medicine News(10 mins):
(Date:2/13/2019)... ... 2019 , ... Sensible Surrogacy today has launched a new ... couples who are unable to afford the staggering cost of surrogacy in the ... America or Eastern Europe for legal and secure surrogacy procedures. However North American ...
(Date:2/13/2019)... ... February 13, 2019 , ... Wound Care centers across the ... EHR software as an app inside their hospital’s EHR, substantially improving continuity of ... (electronic health record) pioneer, will soon launch its award-winning software as an “app” ...
(Date:2/13/2019)... ... February 13, 2019 , ... Abu Dhabi ... Private Partnership (PPP) between the Department of Health-Abu Dhabi (DoH) and Injazat Data ... Information Exchange system (HIE), a centralized platform to streamline healthcare connectivity for the ...
Breaking Medicine Technology:
Cached News: