HOME >> MEDICINE >> NEWS
Scientists observe infectious prion proteins invade and move within brain cells

Scientists for the first time have watched agents of brain-wasting diseases, called transmissible spongiform encephalopathies (TSE), as they invade a nerve cell and then travel along wire-like circuits to points of contact with other cells. These findings will help scientists better understand TSE diseases and may lead to ways to prevent or minimize their effects. TSE, or prion, diseases include scrapie in sheep and goats; chronic wasting disease in deer and elk; mad cow disease in cattle; and Creutzfeldt-Jacob disease in humans.

Under the direction of Byron Caughey, Ph.D., at the Rocky Mountain Laboratories (RML), and Marco Prado, Ph.D., at the University of Minas Gerais in Belo Horizonte, Brazil, the team performed the research in laboratory cultures using a rodent-adapted form of scrapie protein and cells taken from the central nervous system of mouse and hamster brains. The proteins were first "branded" with fluorescent dyes so they could be easily tracked.

The work also revealed that a similar trafficking process might occur with the key plaque-forming protein in Alzheimer's disease, which is not a TSE but a different type of degenerative brain disease, according to Gerald Baron, Ph.D., one of the lead RML researchers. RML, located in Hamilton, MT, is part of the National Institute of Allergy and Infectious Diseases (NIAID) of the National Institutes of Health. The new report appears in the May 25 issue of The Journal of Neuroscience.

"These findings offer intriguing leads toward developing therapies to stop the spread of TSE and possibly other degenerative brain diseases," says NIAID Director Dr. Anthony Fauci. "Potentially, it may be possible to block the pathways that prions use to invade cells, their exit to other cells or their replication within the cells."

Those are precisely some of the next experiments the RML group is pursuing, along with trying to move the fluorescent tracking method from laboratory cell cultures to li
'"/>

Contact: Ken Pekoc
kpekoc@niaid.nih.gov
406-375-9690
NIH/National Institute of Allergy and Infectious Diseases
24-May-2005


Page: 1 2 3

Related medicine news :

1. Scientists train nano-building blocks to take on new shapes, as reported in Science
2. Scientists find war vets hand dexterity determines susceptibility to PTSD
3. Scientists develop method to track immune system enzyme in live animals
4. Scientists from the CIMA investigate a molecule for diagnosing hypertensive cardiopathy
5. Scientists equip bacteria with custom chemo-navigational system
6. Scientists find missing link to understand how plants make vitamin C
7. Scientists and polar explorers brave the elements in support of CryoSat-2
8. Scientists identify cells responsible for relapse after treatment in common childhood cancer
9. Scientists progress in successful tissue engineering
10. Scientists re-grow dental enamel from cultured cells
11. Scientists create dual-modality microbeads to improve identification of disease biomarkers

Post Your Comments:
(Date:5/27/2015)... (PRWEB) May 27, 2015 Allred Dental located ... help patients - who need extensive dental treatment - understand ... treatment options customized for their problems. , Dr. Jeff Allred ... visual presentation of the assessment of the patient’s oral health ... which can treat their oral health problems. , “The dental ...
(Date:5/27/2015)... 27, 2015 Black Book Rankings, ... surveys in the multiple services and software industries, ... the highest ranked Electronic Health and Medical Record ... special research focus on implemented EHR users, Black ... vendors with the highest scores in client experience ...
(Date:5/27/2015)... (PRWEB) May 27, 2015 The MedSpa ... three FDA-approved dermal filler treatments in Abilene, Texas: Xeomin®, ... reduce the appearance of glabellar lines, better known as ... Belotero Balance® is designed to treat smoker’s lines around ... the chin, while Radiesse® improves the appearance of smile ...
(Date:5/27/2015)... Mountain View, CA (PRWEB) May 27, 2015 ... Napa Valley will be able to reach for Organic Coconut ... 2015. Coco Libre will be available at VIP areas, artist ... will also be available at area hotels and on festival ... as a partner this year,” said Noa Elan, Director of ...
(Date:5/27/2015)... Genius Monkey is pleased to announce that ... they have boosted sales for the Utah Honda Dealers ... for seven Utah-based dealers. , Until recently, the ... media. In 2014 the Utah Honda dealers changed their ... Monkey , shifted their marketing campaigns more towards targeted ...
Breaking Medicine News(10 mins):Health News:San Marcos Dentistry Office Offering a New Service Dental Case Planning 2Health News:Cloud-Based Electronic Health Record firms sweep top physician satisfaction rankings for Small and Solo Practices, reveals 2015 Black Book survey 2Health News:Cloud-Based Electronic Health Record firms sweep top physician satisfaction rankings for Small and Solo Practices, reveals 2015 Black Book survey 3Health News:Cloud-Based Electronic Health Record firms sweep top physician satisfaction rankings for Small and Solo Practices, reveals 2015 Black Book survey 4Health News:The MedSpa at Hendrick Introduces Xeomin®, Belotero Balance® and Radiesse® Injectables 2Health News:Coco Libre Puts Organic Coconut Water on the Line-up at BottleRock Napa 2Health News:Genius Monkey Boosts Utah Honda Dealers Website Traffic 142% 2
(Date:5/27/2015)... May 27, 2015 ... the addition of the  "2015 Strategies in ... their offering.       (Logo: http://photos.prnewswire.com/prnh/20130307/600769) ... strategic overview of the orthopedics market, including ... and product categories. , ,In addition, the ...
(Date:5/27/2015)... , May 27, 2015 ... has announced the addition of the  "North ... Forecasts (2014 - 2019)"  report to ... ,  , ,Mammography is a detailed type ... system to inspect breasts. A mammography exam, ...
(Date:5/27/2015)... -- OpportunityAnalyzer: Sepsis - Opportunity Analysis and Forecasts to ... series of diverse complications arising from the presence of ... which cause a rapidly progressing hyperactive host immune response ... depending on disease severity. The syndrome places a major ... marketplace, which for the purposes of this report is ...
Breaking Medicine Technology:Global Orthopedics Market Strategies 2015 2North America Mammography Market - Growth, Trends And Forecasts (2014 - 2019) 2OpportunityAnalyzer: Sepsis - Opportunity Analysis and Forecasts to 2021 2OpportunityAnalyzer: Sepsis - Opportunity Analysis and Forecasts to 2021 3OpportunityAnalyzer: Sepsis - Opportunity Analysis and Forecasts to 2021 4
Cached News: