HOME >> MEDICINE >> NEWS
Scientists show drug can counteract muscular dystrophy in mice

Scientists at the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) and other institutions have demonstrated for the first time that a single drug can rebuild damaged muscle in two strains of mice that develop diseases comparable to two human forms of muscular dystrophy. This advance, which is reported online in Nature Medicine, is the latest from a research collaboration that began several years ago by the teams of Vittorio Sartorelli, M.D., at NIAMS and Pier Lorenzo Puri, M.D., Ph.D., now at Dulbecco Telethon Institute (DTI) in Rome, Italy and The Burnham Institute in La Jolla, Calif.

The scientists tested trichostatin A (TSA), an inhibitor of the enzyme deacetylase, in two mouse models of muscular dystrophy (MD): one that naturally develops a disease similar to Duchenne muscular dystrophy in humans, the other genetically altered to develop a form of dystrophy similar to the human limb-girdle muscular dystrophy. At 45 to 90 days of age, the muscles of the MD mice showed much fibrous tissue and infiltration of inflammatory cells. Unlike healthy mice, the mice with MD were unable to either run on a treadmill or swim. MD mice given TSA daily for two to three months, however, were virtually indistinguishable from healthy mice, and biophysical studies showed virtually no difference between the muscle strength of the mice with MD given the deacetylase inhibitor and healthy mice.

"This is the first example of using a drug to counteract muscular dystrophy in mouse models," says Dr. Sartorelli. Yet he points out that the drug is only promoting muscle regeneration it is not curing the defect that causes muscle deterioration. Further studies are needed to determine how long the drug works and if it works in larger animals with bigger muscles, such as dogs, before such drugs can be tested in people.

The finding has its roots in several of the group's earlier advances, the first of which was reported in 2002 in th
'"/>

Contact: Ray Fleming
flemingr@mail.nih.gov
301-496-8190
NIH/National Institute of Arthritis and Musculoskeletal and Skin Diseases
4-Oct-2006


Page: 1 2

Related medicine news :

1. Scientists train nano-building blocks to take on new shapes, as reported in Science
2. Scientists find war vets hand dexterity determines susceptibility to PTSD
3. Scientists develop method to track immune system enzyme in live animals
4. Scientists from the CIMA investigate a molecule for diagnosing hypertensive cardiopathy
5. Scientists equip bacteria with custom chemo-navigational system
6. Scientists find missing link to understand how plants make vitamin C
7. Scientists and polar explorers brave the elements in support of CryoSat-2
8. Scientists identify cells responsible for relapse after treatment in common childhood cancer
9. Scientists progress in successful tissue engineering
10. Scientists re-grow dental enamel from cultured cells
11. Scientists create dual-modality microbeads to improve identification of disease biomarkers

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Scientists show drug can counteract muscular dystrophy mice

(Date:11/21/2014)... Recently, TideStore.com, a leading online store offering ... special offer TideStore Thanksgiving Sales . According to ... now provided with big discounts. The special offer is ... an extra 10% discount with this coupon code: thanks. ... have opportunities to win free gifts. TideStore.com has done ...
(Date:11/21/2014)... November 21, 2014 TopConsumerReviews.com recently ... an industry leader in the relief of ... significant feelings of sadness and depression each year ... pharmaceutical choices. Often, prescription drugs can produce worse ... drugs are expensive and require regular follow-up visits ...
(Date:11/21/2014)... November 21, 2014 RankingBySEO has announced ... the online reputation of lawyers, and the company has ... announced the service for lawyers since it receives queries ... reputation in big numbers. So far, the company has ... law firms in different parts of the world, and ...
(Date:11/21/2014)... November 21, 2014 First Choice ... 7am today. The new facility is located at 225 ... , “We are pleased to join the Friendswood ... emergency medical care here,” said Dr. Siddiqi, Facility Medical ... , To celebrate the opening, First Choice Emergency Room ...
(Date:11/21/2014)... November 21, 2014 M3 Global Research ... healthcare professional panel, today announced two important leadership changes to ... DasGupta as President of Market Research, Americas and the promotion ... , Ms. DasGupta joined M3 in 2011 and ... recently Head of Sales. Roni has over 17 years ...
Breaking Medicine News(10 mins):Health News:Thanksgiving Sales from TideStore.com 2Health News:Depression Relief Product Receives Top 5-Star Rating from TopConsumerReviews.com 2Health News:RankingBySEO Announces Lawyer Reputation Management Service 2Health News:First Choice Emergency Room Opens New Facility in Friendswood, Texas 2Health News:M3 Global Research Announces Leadership Team Promotions in US and EU 2
(Date:11/21/2014)... Depomed, Inc. (NASDAQ: DEPO ) today announced that it ... Healthcare Conference in New York City . ... 8:00 am EST (5:00 am PST) on Tuesday December 2, 2014.  ... via the Investor Relations page of the Depomed website at ... 30 days on the company,s website. About Depomed ...
(Date:11/21/2014)... Texas , Nov. 21, 2014  Lexicon Pharmaceuticals, ... pricing of its previously announced underwritten public offering of ... an effective shelf registration statement. The offering will consist ... offering price of $1.005 per share.  Lexicon has also ... to 7,462,687 additional shares of common stock.  All of ...
(Date:11/18/2014)... 18, 2014  Sanguine Biosciences – a biotechnology ... study recruitment – will use its proprietary mobile ... Pfizer Inc. find and recruit people diagnosed with ... members to participate in voluntary research, which will ... and hopefully aid in informing the development of ...
Breaking Medicine Technology:Depomed To Present At Piper Jaffray 26th Annual Healthcare Conference 2Lexicon Announces Pricing Of Common Stock Offering 2Lexicon Announces Pricing Of Common Stock Offering 3Sanguine's Mobile Application to Assist Recruitment for Pfizer Inc. Chronic Pain Research 2
Cached News: