HOME >> MEDICINE >> NEWS
Scientists stop colon cancer growth in mice by blocking just one enzyme

GALVESTON, Texas -- Texas researchers have discovered what may become a potent new weapon in the fight against colon cancer.

In cell culture experiments, scientists from the University of Texas Medical Branch at Galveston (UTMB) and the University of Texas at Arlington determined that stopping the activity of a single enzyme called aldose reductase could shut down the toxic network of biochemical signals that promotes inflammation and colon cancer cell growth.

In a dramatic demonstration of the potential of this discovery, they followed up this work with animal studies showing that blocking the production of aldose reductase halted the growth of human colon cancer cells implanted in laboratory mice.

"By inhibiting aldose reductase we were able to completely stop the further growth of colorectal cancer tumor cells," said UTMB professor Satish K. Srivastava, senior author of a paper about the discovery to be published Oct. 1 in the journal Cancer Research.

According to the federal Centers for Disease Control and Prevention, colon cancer is the country's second leading cancer killer. In 2002, the most recent year for which statistics are available, 70,651 men and 68,883 women were diagnosed with colon cancer in the United States; 28,471 men and 28,132 women died from the disease.

In a series of cell-culture experiments, Srivastava and his colleagues--including lead author and postdoctoral fellow Ravinder Tammali, assistant professor Kota V. Ramana, and Sharad S. Singhal and Sanjay Awasthi of the University of Texas at Arlington-- investigated aldose reductase's role in colon cancer cell growth. First they stimulated colon cancer cells with growth factors, chemicals known to kick-start inflammatory chain reactions that encourage colon cancer cells to proliferate; this proliferation process then itself produces even more inflammation and cancer cell growth. (Chronic inflammation is strongly linked to the development of c
'"/>

Contact: Jim Kelly
jpkelly@utmb.edu
409-772-8791
University of Texas Medical Branch at Galveston
1-Oct-2006


Page: 1 2 3

Related medicine news :

1. Scientists train nano-building blocks to take on new shapes, as reported in Science
2. Scientists find war vets hand dexterity determines susceptibility to PTSD
3. Scientists develop method to track immune system enzyme in live animals
4. Scientists from the CIMA investigate a molecule for diagnosing hypertensive cardiopathy
5. Scientists equip bacteria with custom chemo-navigational system
6. Scientists find missing link to understand how plants make vitamin C
7. Scientists and polar explorers brave the elements in support of CryoSat-2
8. Scientists identify cells responsible for relapse after treatment in common childhood cancer
9. Scientists progress in successful tissue engineering
10. Scientists re-grow dental enamel from cultured cells
11. Scientists create dual-modality microbeads to improve identification of disease biomarkers

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/17/2017)... ... February 17, 2017 , ... ... services, announced today that Karen Pilley has been promoted to Chief Executive Officer. ... today’s shifting healthcare paradigm – a shift that demands the transition from pay-for-service ...
(Date:2/17/2017)... ... February 17, 2017 , ... Like most hospitals across the nation, Onslow Memorial ... by the Hospital Readmission Reduction Program (HRRP), the return of a patient to the ... across the nation. While many providers are struggling to leverage limited resources and technology, ...
(Date:2/16/2017)... ... February 17, 2017 , ... ... took over 10 years of research, development and clinical trials, the founder of ... is a patented compound of FDA approved ingredients that when infused into alcohol, ...
(Date:2/16/2017)... ... February 16, 2017 , ... ... and superiority in patient care, NWH has achieved Magnet® recognition for ... Tuesday, January 31, 2017. The American Nurses Credentialing Center’s Magnet Recognition Program® distinguishes ...
(Date:2/16/2017)... ... February 16, 2017 , ... A February 6 ... as fat freezing or CoolSculpting, noting that some 425,000 procedures were performed with the ... that the clinic is, in fact, seeing a great deal of interest from area ...
Breaking Medicine News(10 mins):
(Date:2/17/2017)... YORK , Feb. 17, 2017  Noble Capital ... on ESSA Pharma Inc. (Nasdaq: EPIX ). ... Research, Kumar Raja , PhD. ESSA ... for castration resistant prostate cancer (CRPC). Its lead compound ... blocks the amino-terminal domain of the androgen receptor, thereby ...
(Date:2/16/2017)... , Feb. 16, 2017 The global ... USD 7.88 billion by 2021 from USD 5.49 billion ... On the basis of type, the preparative and ... preparative chromatography. In 2016, the process chromatography segment is ... global preparative and process chromatography. Growth in this segment ...
(Date:2/16/2017)... , Feb. 16, 2017  AcelRx Pharmaceuticals, Inc. ... company focused on the development and commercialization of ... pain, announced that Vincent J. Angotti ... member of the company,s board of directors, effective ... two decades of experience leading executive and commercial ...
Breaking Medicine Technology:
Cached News: