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Scripps research combination therapy obliterates new vessel growth in tumors and retinopathy

e use of lower doses of angiostatic therapies could minimize potential adverse side effects.

"The point of the study was to show proof-of-concept that targeting multiple angiogenic pathways will be more effective than inhibiting single ones due to potential compensatory upregulation," Friedlander said. "As more and more anti-angiogenic agents reach the market, there will be even more combinations to choose from. In our laboratory, we're now looking at new combinations of approved angiostatic drugs to see if we can achieve similar promising results that can have immediate translation into the clinic."


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Contact: Marisela Chevez
mchevez@scripps.edu
858-784-2171
Scripps Research Institute
9-Jan-2007


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