HOME >> MEDICINE >> NEWS
Search for cancer genes unlikely to succeed, say experts

The hunt to find common genes that are associated with cancer is unlikely to be successful, say experts in this week's BMJ.

Huge resources are being invested in the search for common inherited genetic variants that increase susceptibility to cancer. One US project, for example, will cost $14m. But devoting a large research effort to searching for common cancer susceptibility genes has several problems, write authors Stuart Baker and Jaakko Kaprio.

The first is that recent research suggests these genes are unlikely to exist or, if they do, are unlikely to have much of an effect on the incidence of cancer.

A second reason to play down the role of common susceptibility genes is studies suggesting that environmental, dietary, or lifestyle changes have a large effect on the incidence of cancer. These studies show changes in incidence within one or two generations, which is probably too quick to be related to the introduction of new genes.

A final reason to be sceptical comes from results from a study of cancers in twins. By analysing data from identical and non-identical twins, the authors showed that genetic susceptibility made only a small to moderate contribution to the incidence of cancer.

Studies that have shown links between common genes and cancer may be due to bias.

But, even if susceptibility genes were identified, showing clinical benefit would still be difficult, and further large trials would be needed, they add.

"The search for common cancer susceptibility genes faces important methodological and practical challenges for cancer prevention, given the small chance that such genetic variants exist and the difficulty and expense of proving substantial clinical benefit if they do exist," they conclude. "Enthusiasm for this new field of research should not precipitate unwarranted expectations."


'"/>

Contact: Emma Dickinson
edickinson@bmj.com
44-020-738-36529
BMJ-British Medical Journal
11-May-2006


Page: 1

Related medicine news :

1. Search for bipolar gene, toll of disease topics of conference call briefings June 16, 17
2. Conventional prognostic factors fail to explain better prostate cancer survival in most Asian men
3. Survival differences by race most apparent in advanced stages of breast cancer
4. Stomach cancer rate set to fall further 25 percent over next decade
5. MRI finds breast cancer before it becomes dangerous
6. Investigators uncover intriguing clues to why persistent acid reflux sometimes turns into cancer
7. New cause of tamoxifen resistance in breast cancer cells discovered at Lombardi
8. Pathway links inflammation, angiogenesis and breast cancer
9. Using MRI for diagnosis could help prevent breast cancer progression
10. Electric fields have potential as a cancer treatment
11. Shining light on pancreatic cancer

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Search for cancer genes unlikely succeed say experts

(Date:9/1/2015)... (PRWEB) , ... September 01, 2015 , ... Routines… every ... – routines can help make things easier for parents, caregivers and children too. Here ... routines, transitions both big and small become more fluid. When a routine is implemented ...
(Date:9/1/2015)... ... September 01, 2015 , ... September is Baby Safety Month, and Lightning ... stickers to keep little ones' safety top of mind at all times. , Sponsored ... focus. According to the JPMA's Baby Safety Zone website, this year's theme is A ...
(Date:9/1/2015)... ... September 01, 2015 , ... ... of professional hair salons. This highly anticipated partnership between Curly Hair Solutions™ and ... Styling Collection. Founder Jonathan Torch and the Curly Hair Solutions™ team could not ...
(Date:8/31/2015)... Orange, NJ (PRWEB) , ... September 01, 2015 ... ... the spine to eliminate chronic back pain – once required a long, arduous ... a shorter hospital stay, less pain, less blood loss and minimal muscle damage. ...
(Date:8/31/2015)... ... August 31, 2015 , ... Cosmetic ... the resources they need to have a successful cosmetic procedure; from publishing encyclopedic ... Cosmetic Town Journal is always ready to help. , It is clear that ...
Breaking Medicine News(10 mins):Health News:Back into the Swing of Things: How Family Routines Benefit Children 2Health News:Lightning Labels Can Help Make A Difference This Baby Safety Month 2Health News:Lightning Labels Can Help Make A Difference This Baby Safety Month 3Health News:Curly Hair Solutions™ Partners With Trade Secrets 2Health News:Minimally Invasive Spinal Fusions Squash Back Pain without Arduous Recovery 2Health News:Minimally Invasive Spinal Fusions Squash Back Pain without Arduous Recovery 3Health News:Minimally Invasive Spinal Fusions Squash Back Pain without Arduous Recovery 4Health News:Cosmetic Town: A One Stop Plastic Surgery Community 2
(Date:8/31/2015)... Aug. 31, 2015  DICOM Grid,  the #1 ... it was recognized as a semifinalist for a ... The awards are sponsored by Auntminnie.com, a ... in the medical imaging industry.  Since 1999, the ... to acknowledge the contributions of their peers. Nominations ...
(Date:8/31/2015)... JERUSALEM, Israel, Aug. 31, 2015  Chiasma, Inc. ... company developing octreotide capsules for the orphan condition ... quarter ended June 30, 2015 and provided a ... have been a transformative time for Chiasma, as ... recently announced that our first New Drug Application ...
(Date:8/31/2015)... Thousands of people will peacefully demonstrate their ... addiction epidemic at dozens of rallies across the country ... the United States has experienced skyrocketing ... and heroin, yet the President has never once spoken ... letter to President Obama , rally organizers compared his ...
Breaking Medicine Technology:DG Suite Nabs "Minnies" Nomination for "Best New Radiology Software" 2Chiasma Reports Second Quarter 2015 Financial Results and Recent Business Highlights 2Chiasma Reports Second Quarter 2015 Financial Results and Recent Business Highlights 3Chiasma Reports Second Quarter 2015 Financial Results and Recent Business Highlights 4Chiasma Reports Second Quarter 2015 Financial Results and Recent Business Highlights 5Chiasma Reports Second Quarter 2015 Financial Results and Recent Business Highlights 6Chiasma Reports Second Quarter 2015 Financial Results and Recent Business Highlights 7Chiasma Reports Second Quarter 2015 Financial Results and Recent Business Highlights 8Chiasma Reports Second Quarter 2015 Financial Results and Recent Business Highlights 9Obama Administration's Neglect of Opioid Crisis Prompts Rallies in Many States 2
Cached News: