HOME >> MEDICINE >> NEWS
Search for cancer genes unlikely to succeed, say experts

The hunt to find common genes that are associated with cancer is unlikely to be successful, say experts in this week's BMJ.

Huge resources are being invested in the search for common inherited genetic variants that increase susceptibility to cancer. One US project, for example, will cost $14m. But devoting a large research effort to searching for common cancer susceptibility genes has several problems, write authors Stuart Baker and Jaakko Kaprio.

The first is that recent research suggests these genes are unlikely to exist or, if they do, are unlikely to have much of an effect on the incidence of cancer.

A second reason to play down the role of common susceptibility genes is studies suggesting that environmental, dietary, or lifestyle changes have a large effect on the incidence of cancer. These studies show changes in incidence within one or two generations, which is probably too quick to be related to the introduction of new genes.

A final reason to be sceptical comes from results from a study of cancers in twins. By analysing data from identical and non-identical twins, the authors showed that genetic susceptibility made only a small to moderate contribution to the incidence of cancer.

Studies that have shown links between common genes and cancer may be due to bias.

But, even if susceptibility genes were identified, showing clinical benefit would still be difficult, and further large trials would be needed, they add.

"The search for common cancer susceptibility genes faces important methodological and practical challenges for cancer prevention, given the small chance that such genetic variants exist and the difficulty and expense of proving substantial clinical benefit if they do exist," they conclude. "Enthusiasm for this new field of research should not precipitate unwarranted expectations."


'"/>

Contact: Emma Dickinson
edickinson@bmj.com
44-020-738-36529
BMJ-British Medical Journal
11-May-2006


Page: 1

Related medicine news :

1. Search for bipolar gene, toll of disease topics of conference call briefings June 16, 17
2. Conventional prognostic factors fail to explain better prostate cancer survival in most Asian men
3. Survival differences by race most apparent in advanced stages of breast cancer
4. Stomach cancer rate set to fall further 25 percent over next decade
5. MRI finds breast cancer before it becomes dangerous
6. Investigators uncover intriguing clues to why persistent acid reflux sometimes turns into cancer
7. New cause of tamoxifen resistance in breast cancer cells discovered at Lombardi
8. Pathway links inflammation, angiogenesis and breast cancer
9. Using MRI for diagnosis could help prevent breast cancer progression
10. Electric fields have potential as a cancer treatment
11. Shining light on pancreatic cancer

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Search for cancer genes unlikely succeed say experts

(Date:10/31/2014)... 2014 Energy Textiles has recently added ... gear is now available online, and Energy Textile is ... Celliant infrared-active athletic gear over compression gear. , ... has been signed for Under Armour to provide team ... eight years. In light of this decision, Energy Textiles ...
(Date:10/31/2014)... of treatment and cost, patients with early stage ... irradiation (APBI) with proton therapy versus whole breast ... University of Texas MD Anderson Proton Therapy Center. ... based on typical patient characteristics, researchers used Medicare ... different types of partial and whole breast irradiation ...
(Date:10/31/2014)... 31, 2014 Gold Medal Wine Club ... affordable but tasteful gifts for the wine novice and enthusiasts ... Bird Gift Giving Special , which Early Bird shoppers receive ... Wine Club Gift membership. , Gift Givers must place ... special. Besides offering discounts, Gold Medal Wine Club adds more ...
(Date:10/31/2014)... scientists have found a drug combination that can trigger ... the way for new treatments, according to research that ... (NCRI) Cancer Conference in Liverpool next week*. , When ... chain of events culminating in self destruction. But cancer ... immortal. This means that cells grow out of control ...
(Date:10/31/2014)... Miami, FL (PRWEB) October 31, 2014 ... recently volunteered his hair restoration services to transform the ... part of the American Academy of Facial Plastic and ... donated his time to restore the facial hair Jones ... , The pro-bono hair restoration procedure, valued ...
Breaking Medicine News(10 mins):Health News:Compression Gear--Is There a Better Alternative? 2Health News:Compression Gear--Is There a Better Alternative? 3Health News:Compression Gear--Is There a Better Alternative? 4Health News:Proton therapy shown to be less costly than some alternative radiotherapy techniques 2Health News:Proton therapy shown to be less costly than some alternative radiotherapy techniques 3Health News:Gold Medal Wine Club now offering Early Bird Gift Giving Special for Holidays 2Health News:Scientists trigger self-destruct switch in lung cancer cells 2Health News:Miami Hair Restoration Specialist Transforms Wounded Soldier 2
(Date:10/31/2014)... Oct. 31, 2014  Isis Pharmaceuticals, Inc. (NASDAQ: ...  What: , Isis Pharmaceuticals, Third Quarter 2014 Financial ... 7 at 11:30 a.m. ET / 8:30 a.m. PTWhere: ... the Internet. Simply log onto our website listed above. ... event, a replay of the webcast will be available ...
(Date:10/30/2014)... , Oct. 30, 2014 /CNW/ - Atlantic Canadians ... agreement reached between Canada,s provinces ... Keon , President of the Canadian Generic Pharmaceutical Association ... the comments while speaking at the Atlantic Summit on ... , which is being hosted by the Public ...
(Date:10/30/2014)... 30, 2014   NxStage® Kidney Care, Inc ., a ... is proud to host the grand opening ceremony of its ... W. 16 th Street on November 20, 2014 from ... trained medical staff who are committed to providing patients with ... benefits made possible through more flexible dialysis treatment options.   ...
Breaking Medicine Technology:Webcast Alert: Isis Pharmaceuticals' Third Quarter 2014 Financial Results Conference Call 2Webcast Alert: Isis Pharmaceuticals' Third Quarter 2014 Financial Results Conference Call 3Atlantic Canadians to Save $560-Million Through Unprecedented Three-Year Pan-Canadian Agreement on Generic Prescription Medicines 2Atlantic Canadians to Save $560-Million Through Unprecedented Three-Year Pan-Canadian Agreement on Generic Prescription Medicines 3Grand Opening of NxStage Kidney Care Oak Brook IL Center 2Grand Opening of NxStage Kidney Care Oak Brook IL Center 3
Cached News: