Approximately 2.5 in 100,000 women develop inflammatory breast cancer, which is characterized by rapid tumor growth, early metastasis (cancer spreading to other parts of the body) and poor survival rates as compared with other forms of breast cancer, according to background information in the article. Combining surgery, chemotherapy, radiation therapy and endocrine therapy has improved survival rates and become the standard of care for patients with this disease. Some recent studies have suggested that performing surgery before beginning other types of treatment may improve survival rates.
Rory L. Smoot, M.D., and colleagues at Mayo Clinic College of Medicine, Rochester, Minn., reviewed data from the records of 156 consecutive patients (155 female, one male) who were treated there for inflammatory breast cancer between 1985 and 2003. Twenty-eight patients with cancer that had already metastasized at their first visit were excluded from the study. The remaining 128 patients had an average age of 53 years, and 57 percent of women were post-menopausal.
By 2003, 51 patients (40 percent) survived and 77 (60 percent) died; five-year survival rates were 42 percent with 21 percent surviving disease-free. Of the 128 patients without metastatic disease, 22 (17 percent) had surgery as their initial treatment and 106 (83 percent) underwent chemotherapy first. Although some analyses showed that patients who had surgery first lived longer than those who did not, the results were not significant when other factors were taken into account. In addition, certain aspects of each patients' prognosis likely influenced her and her physician's treatment decisions, making outcomes diff
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Contact: Elizabeth Zimmermann
507-266-0810
JAMA and Archives Journals
19-Jun-2006