HOME >> MEDICINE >> NEWS
Sex hormones hold key to higher rates of abdominal aortic aneurysms in males

Men have a four times greater risk than women of developing abdominal aortic aneurysms, estimated to be the cause of death in 4 percent of people over the age of 65, but the mechanism for this higher incidence has remained unknown. Researchers at the University of Kentucky now report evidence that the answer lies in male sex hormones. They found that removing circulating androgens, including testosterone and dihydrotestosterone, from male mice lowers their risk of aneurysm to that of females, while giving females these same male sex hormones increases their risk to that of males.

Tracy Henriques, a graduate student in the laboratories of Drs. Lisa Cassis and Alan Daugherty, presented the study Monday, April 4, at the American Society for Investigative Pathology scientific sessions at Experimental Biology 2005 in San Diego.

In a well-established research method, giving hyperlipidemic mice the peptide hormone angiotensin II results in the development of abdominal aortic aneurysms. Not surprisingly, considering the gender differences in humans, male mice have a three-fold higher susceptibility to developing the angiotensin-induced aneurysms than age-matched females receiving the same drug. Recent studies in the Cassis/Daugherty laboratories revealed that removing the male sex hormones reduced the incidence of aneurysms in male mice to the same lower levels seen in the females.

In this new study, the researchers found that giving male sex hormones to female mice at the time of the angiotensin infusion turns the females into males in terms of their susceptibility. Administration of testosterone raised the incidence of developing abdominal aortic aneurysms by 55 percent in the females; dihydrotestosterone raised the incidence to 67 percent. In addition, the females given male sex hormones developed more severe aneurysms compared to placebo treated female mice.

The goal of the laboratory now is to find the target of the male sex hormones t
'"/>

Contact: Sarah Goodwin
ebpress@bellsouth.net
770-270-0989
Federation of American Societies for Experimental Biology
4-Apr-2005


Page: 1 2

Related medicine news :

1. Your brain and hormones may conspire to make you fat
2. Smoking, eating and thinking: New research on the brain, hormones, and behavior
3. The brain, hormones and behavior focus of briefings at international meeting June 19-22
4. Neuroendocrinology Congress June 1922 to report new research on brain, hormones, behavior
5. BRCA1 gene found to inhibit two sex hormones, not just one
6. Depressed heart patients skip medications, have elevated stress hormones
7. Women with migraines and visual symptoms may have higher stroke risk
8. Study explains why patients with OSA are at higher risk for cardiovascular disease
9. Tiny newborns face higher risk of death at community hospitals, Stanford/VA study finds
10. Persistent smokers may have higher risk to become depressed than never smokers
11. Veterans exposed to Agent Orange have higher rates of prostate cancer recurrence

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/28/2020)... ... March 28, 2020 , ... Confluent Health is proud ... therapist-owned rehabilitation company since 1985 specializing in the treatment of orthopedic, sports, and ... more than 30 years ago, we have been committed to providing excellent quality ...
(Date:3/27/2020)... ... March 27, 2020 , ... NeoTract, a ... the field of urology, today announced that Harpreet Wadhwa, M.D., East Valley Urology ... The designation recognizes that Dr. Wadhwa has achieved a high level of training ...
(Date:3/22/2020)... ... March 21, 2020 , ... In partnership with UC Health, Cincy Shirts has ... professionals and first responders. The title comes from the English translation of “Juncta Juvant”, ... flag. , Proceeds from the sale of the shirt will benefit the YMCA ...
(Date:3/22/2020)... ... March 22, 2020 , ... In times of crisis, like ... frivolous luxury. The world’s focus is on practical matters - on self-isolation, social ... and control in chaos. However, it’s during these times that “self-awareness” is crucial, ...
(Date:3/20/2020)... Quebec (PRWEB) , ... March 20, 2020 , ... ... to bring together an interdisciplinary team of researchers in machine learning, bioinformatics, immunology, ... deployed in current and future outbreaks. , "The COVID-19 crisis gives us an ...
Breaking Medicine News(10 mins):
(Date:4/1/2020)... ... April 01, 2020 , ... The new ... today, with the first live-streaming broadcast premiering on April 2. , The live ... interviewing a variety of animal keepers and veterinary hospital staff with different animals. ...
(Date:3/30/2020)... ... March 30, 2020 , ... CPSI ... TalkWithYourDoc.com . By leveraging technology developed by its wholly owned subsidiary, ... continue offering revenue-generating healthcare services while serving patients’ needs during the COVID-19 outbreak. ...
(Date:3/30/2020)... TRIANGLE PARK, N.C. (PRWEB) , ... March 30, ... ... and operations, today announced it has been recognized by Dresner Advisory Services as ... recognizes Zaloni for its capabilities related to data orchestration, data transformation, and data ...
Breaking Medicine Technology:
Cached News: