HOME >> MEDICINE >> NEWS
Shape-altering genes linked to ovarian cancer

HOUSTON - Frequently referred to as a silent killer, ovarian cancer offers few clues to its presence, often until it has spread beyond the ovary to other tissues. Early detection has been difficult because ovarian cancer is not a single disease, but appears in many forms, with each form behaving differently. Now researchers from The University of Texas M. D. Anderson Cancer Center have explained how and why different forms of ovarian cancer evolve in a discovery that could lead to earlier detection and perhaps more personalized treatment for a disease that will claim an estimated 16,210 women's lives in the United States in 2005.

Honami Naora, Ph.D., an assistant professor in M. D. Anderson's Department of Molecular Therapeutics and her colleagues discovered that a set of shape-altering genes become activated in ovarian cancer. These HOX genes, better known for their role in normal embryonic development, direct the cancer cells to take a variety of different forms, depending on which of the genes is turned on. The researchers reported their finding in the April 10, 2005 on-line issue of the journal Nature Medicine.

"Our finding explains how each of the three major forms of ovarian cancer acquire their unique appearance," says Naora. "These genes cause a metamorphosis of the ovarian epithelial cells, directing them to change their shape."

These strange shapes make each form of ovarian cancer different from one another, and also different to the surface epithelium or outer covering of the ovary from which these cancers are thought to arise, explained Naora. Serous ovarian cancer exhibits features resembling those of the fallopian tubes; the endometrioid form has features resembling the lining of the uterus; mucinous ovarian cancer even looks like intestinal cells.

These mysterious shapes have caused some researchers to speculate that ovarian cancers might originate from some other tissues, and not the ovarian surface epithelium at all.
'"/>

Contact: Nancy Jensen
nwjensen@mdanderson.org
713-792-0655
University of Texas M. D. Anderson Cancer Center
15-Apr-2005


Page: 1 2 3

Related medicine news :

1. Pathway links inflammation, angiogenesis and breast cancer
2. Inflammatory system genes linked to cognitive decline after heart surgery
3. New angiogenesis inhibitor has promise for treating deadly brain tumor
4. Risk of spina bifida associated with choline metabolism genes, but unrelated to choline intake
5. Researchers show surprising interaction between genes, gender and hypertension
6. Researchers identify genes that allow brain cancer-causing stem cells to resist treatment
7. NHGRI funds assessment of public attitudes about population-based studies on genes and environment
8. Claiming diagnostic tests for diabetes genes is misleading, say experts
9. Zebrafish show advantages in assessing human cancer cell-induced angiogenesis in vivo
10. Variations in detoxifying genes linked to Lou Gehrigs disease
11. Researchers link two more genes to sudden infant death syndrome

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Shape altering genes linked ovarian cancer

(Date:11/27/2014)... November 27, 2014 “Wekho” was featured on ... latest and coolest mobile applications on the iOS, Android, and ... of NewsWatch, conducted the app review and shared ... of people. , An interesting new way to travel and ... Android devices. It’s called Wekho and it’s a free ...
(Date:11/27/2014)... Washington, DC (PRWEB) November 27, 2014 “LAB.C” ... Report, which features the latest and coolest technology products available ... NewsWatch, conducted the product review and shared with ... cable for iOS and Android devices. , Consumers love portability ... LAB.C. Their Cable Case for the iPhone5 and 5S ...
(Date:11/27/2014)... November 27, 2014 Developers and plugin specialist ... plugin entitled ProPip, taking FCPX to the next level. , ... with a few clicks of a mouse,” said Christina Austin, ... that our users will appreciate.” , With ProPip users can ... the possibilities truly endless. ProPip is great for commentaries, news ...
(Date:11/27/2014)... 27, 2014 Dr. Ronald Receveur, who has ... a few oral health tips before patients dig into the ... and New Albany affordable cosmetic dentistry, and his ... starch and sugar. While the staff wishes everyone a happy ... for how patients can enjoy a feast that is also ...
(Date:11/27/2014)... This is a professional and in ... an overview analysis, the report introduces Insulin basic ... industry overview, policy analysis, and news analysis, etc. ... information on policy, plans for Insulin Market product ... more. , This report also provides ...
Breaking Medicine News(10 mins):Health News:A New Geolocation Mobile Application and was Featured on NewsWatch Television on October 30, 2014 2Health News:Top Mobile Friendly Accessories were Featured on NewsWatch Television on October 30, 2014 2Health News:Pixel Film Studios released ProPip plugin Exclusively for Final Cut Pro X 2Health News:Pixel Film Studios released ProPip plugin Exclusively for Final Cut Pro X 3Health News:New Albany Dental Practice Offers Oral Health Tips For Thanksgiving 2Health News:New Albany Dental Practice Offers Oral Health Tips For Thanksgiving 3Health News:New Albany Dental Practice Offers Oral Health Tips For Thanksgiving 4Health News:Insulin Industry Analysis (Supply, Consumption) for China, America, Korea, France & Japan Research Now at ReportsnReports 2Health News:Insulin Industry Analysis (Supply, Consumption) for China, America, Korea, France & Japan Research Now at ReportsnReports 3
(Date:11/27/2014)... 27, 2014 - New Solution ... - JIN Co., Ltd. will launch JINS MEME ... of 500,000 yen or $5,000 (without tax /including two pairs ... PACK" is a dedicated solution of "JINS MEME" to academic ... deep data* generated by electrooculography and six-axis sensors without API. ...
(Date:11/26/2014)... Nov. 26, 2014  Thoratec Corporation (NASDAQ: ... support therapies to save, support and restore failing hearts, ... investor conferences. On Tuesday, December 2, the ... Piper Jaffray Healthcare Conference.  D. Keith Grossman , ... on the company beginning at 11:30 a.m., Eastern Standard ...
(Date:11/26/2014)... ANDOVER, Mass. , Nov. 26, 2014 /PRNewswire/ ... AEX: PHIA) today announced expanded availability of ... including DuraDiagnost, DigitalDiagnost, MobileDiagnost wDR, MobileDiagnost Opta[i] , ... of these solutions now available in the U.S., ... global markets, the portfolio offers Philips, customers innovative ...
Breaking Medicine Technology:JIN to Launch JINS MEME ACADEMIC PACK in Late April 2015 2JIN to Launch JINS MEME ACADEMIC PACK in Late April 2015 3Thoratec Announces Presentations At Investor Conferences For December 2014 2Philips expands global reach of diagnostic X-Ray solutions 2Philips expands global reach of diagnostic X-Ray solutions 3
Cached News: