HOME >> MEDICINE >> NEWS
Shape-altering genes linked to ovarian cancer

HOUSTON - Frequently referred to as a silent killer, ovarian cancer offers few clues to its presence, often until it has spread beyond the ovary to other tissues. Early detection has been difficult because ovarian cancer is not a single disease, but appears in many forms, with each form behaving differently. Now researchers from The University of Texas M. D. Anderson Cancer Center have explained how and why different forms of ovarian cancer evolve in a discovery that could lead to earlier detection and perhaps more personalized treatment for a disease that will claim an estimated 16,210 women's lives in the United States in 2005.

Honami Naora, Ph.D., an assistant professor in M. D. Anderson's Department of Molecular Therapeutics and her colleagues discovered that a set of shape-altering genes become activated in ovarian cancer. These HOX genes, better known for their role in normal embryonic development, direct the cancer cells to take a variety of different forms, depending on which of the genes is turned on. The researchers reported their finding in the April 10, 2005 on-line issue of the journal Nature Medicine.

"Our finding explains how each of the three major forms of ovarian cancer acquire their unique appearance," says Naora. "These genes cause a metamorphosis of the ovarian epithelial cells, directing them to change their shape."

These strange shapes make each form of ovarian cancer different from one another, and also different to the surface epithelium or outer covering of the ovary from which these cancers are thought to arise, explained Naora. Serous ovarian cancer exhibits features resembling those of the fallopian tubes; the endometrioid form has features resembling the lining of the uterus; mucinous ovarian cancer even looks like intestinal cells.

These mysterious shapes have caused some researchers to speculate that ovarian cancers might originate from some other tissues, and not the ovarian surface epithelium at all.
'"/>

Contact: Nancy Jensen
nwjensen@mdanderson.org
713-792-0655
University of Texas M. D. Anderson Cancer Center
15-Apr-2005


Page: 1 2 3

Related medicine news :

1. Pathway links inflammation, angiogenesis and breast cancer
2. Inflammatory system genes linked to cognitive decline after heart surgery
3. New angiogenesis inhibitor has promise for treating deadly brain tumor
4. Risk of spina bifida associated with choline metabolism genes, but unrelated to choline intake
5. Researchers show surprising interaction between genes, gender and hypertension
6. Researchers identify genes that allow brain cancer-causing stem cells to resist treatment
7. NHGRI funds assessment of public attitudes about population-based studies on genes and environment
8. Claiming diagnostic tests for diabetes genes is misleading, say experts
9. Zebrafish show advantages in assessing human cancer cell-induced angiogenesis in vivo
10. Variations in detoxifying genes linked to Lou Gehrigs disease
11. Researchers link two more genes to sudden infant death syndrome

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... QUEENS, N.Y (PRWEB) , ... October 13, 2017 , ... ... recently became a member of ElderCounsel, a national organization of elder law and special ... constantly changing laws and rules. It also provides a forum to network with elder ...
(Date:10/13/2017)... ... October 13, 2017 , ... The Visiting Nurse Association (VNA) of Somerset Hills ... specialty vendors and unique items from across the nation, this holiday-themed event will raise ... offered by the VNA. The boutique will be open Saturday, November 4 (10:00 ...
(Date:10/13/2017)... ... October 13, 2017 , ... Yisrayl Hawkins, Pastor and ... explains one of the most popular and least understood books in the Holy Scriptures, ... puzzling descriptions that have baffled scholars for centuries. Many have tossed it off as ...
(Date:10/13/2017)... ... 2017 , ... “The Journey: From the Mountains to the Mission Field”: the ... in the Philippines. “The Journey: From the Mountains to the Mission Field” is the ... She has taught all ages and currently teaches a class of ladies at her ...
(Date:10/12/2017)... ... October 12, 2017 , ... CitiDent ... sleep apnea using cutting-edge Oventus O2Vent technology. As many as 18 million ... by frequent cessation in breathing. Oral appliances can offer significant relief to about ...
Breaking Medicine News(10 mins):
(Date:10/11/2017)... 11, 2017  Caris Life Sciences ® , a ... promise of precision medicine, today announced that St. Jude ... Oncology Alliance™ (POA) as its 17 th member. ... Jude Crosson Cancer Institute will help develop standards of ... tumor profiling, making cancer treatment more precise and effective. ...
(Date:10/11/2017)... , Oct. 11, 2017  Hill-Rom Holdings, Inc. ("Hill-Rom") ... Surgical facility in Las Piedras, Puerto Rico ... and blades. ... the facility sustained minor structural damage, temporary loss of ... Repairs have been completed, manufacturing operations have resumed, and ...
(Date:10/10/2017)... Pa. , Oct. 10, 2017   West ... in innovative solutions for injectable drug administration, today shared ... West,s ID Adapter for improving the intradermal administration of ... Fourth Skin Vaccination Summit in May 2017 by Dr. ... Lead, Polio Department, World Health Organization (WHO), and recently ...
Breaking Medicine Technology:
Cached News: