HOME >> MEDICINE >> NEWS
Short sugar chains-a future drug for Alzheimer's?

Heparansulfate, which is needed for normal fetal development among other things, is also important for the build-up of amyloid, morbid protein deposits that appear in several serious diseases. This is shown by Uppsala scientists in an article published in today's Net edition of the U.S. journal Proceedings of the National Academy of Science.

Heparansulfate, long chains of sugar molecules, is produced by most cells in the body. It was not previously known that heparansulfate is necessary for the occurrence of amyloid, abnormal protein deposits in the body. Amyloid appears in several grave disorders, such as Alzheimer's disease, mad-cow disease, old-age diabetes, and so-called AA amyloidosis, which often develops in chronic inflammatory diseases.

The research team is headed by Professor Ulf Lindahl and Associate Professor Jin-ping Li at the Department of Medical Biochemistry and Microbiology at Uppsala University. They have studied how heparansulfate binds the abnormal protein molecules and thereby triggers amyloid deposits. In experiments the researchers have used genetically altered mice that produce much higher than normal amounts of the enzyme heparanase. This enzyme cuts the normal-length heparansulfate chain into short segments. Both the genetically altered and the normal control mice were stimulated with a treatment that usually leads to rapid build-up of amyloid (AA amyloidosis) in several internal organs, including the liver, the kidneys, and the spleen. The heparanase-producing mice proved to be completely resistant to amyloidosis of the liver and kidneys, organs with pronounced overproduction of the enzyme and therefore very short heparansulfate fragments. On the other hand, they did develop amyloid in the spleen, which had avoided overproduction of heparanase and therefore contained normal size heparansulfate. The control mice developed amyloidosis of the spleen and of the liver and kidneys. The findings indicate that the occurrence of
'"/>

Contact: Anneli Waara
anneli.waara@uadm.uu.se
46-18-471-1974
Swedish Research Council
19-Apr-2005


Page: 1 2

Related medicine news :

1. Shorter post-operative recovery stay following outpatient tonsillectomy is safe, cost-efficient
2. Short episodes of manic symptoms may indicate bipolar disorder in some youth
3. Short-term topical corticosteroid use may offer relief for patients with acute form of psoriasis
4. Shorter distance on six-minute walk test points up a greater risk of death
5. Short-term intervention programs have potential to reduce teen methamphetamine use
6. Short term follow-up proves to be helpful
7. Short glasses more likely to lead to over-indulgence
8. Short-term survival rates better for US vs. Canadian heart failure patients
9. Shortness of breath without chest pain can signify the presence of high risk heart disease
10. Short-term hormone therapy can improve outlook for men with early prostate cancer
11. Shorter course of radiotherapy effective for palliation of painful bone metastases

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/28/2017)... Columbia (PRWEB) , ... June 28, 2017 , ... ... (FSE: ZEON) is pleased to announce that a two year study conducted by ... Company's Bromley Creek zeolite was successful in remediating potash brine-impacted groundwater. As a ...
(Date:6/27/2017)... , ... June 27, 2017 , ... ... the appointment of Mike Finnegan to the position of Executive Vice President, Sales ... experience in healthcare technology, telehealth and medical device sales leadership. He has received ...
(Date:6/27/2017)... ... June 27, 2017 , ... The Congressional Budget Office ... repeal and replace the 2010 Patient Protection and Affordable Care Act (ACA), would result ... would be expected under current law. , More than 20 million Americans have gained ...
(Date:6/27/2017)... ... June 27, 2017 , ... ... personal financial planning services to residents of southern New Hampshire, is teaming up ... promises to fight hunger and homelessness in the region. , New Horizons for ...
(Date:6/27/2017)... ... June 27, 2017 , ... Hammer Strength, the world’s leading performance strength training ... of the Houston Rockets the NBSCA Strength & Conditioning Coach of the Year. ... members who vote to select the coach who embodies the highest level of excellence ...
Breaking Medicine News(10 mins):
(Date:6/20/2017)... LAGUNA HILLS, Calif. , June 20, 2017 ... that validate the use of MMprofiler with SKY92, the ... myeloma (MM). In a poster presentation at the 22 ... in Madrid, Spain , SkylineDx researchers ... high-risk elderly patients. In a separate ...
(Date:6/16/2017)... , June 16, 2017 Datascope Corp. is voluntarily performing ... Corp. for a potential electrical test failure code.     ... PART NUMBER ... CS300 IABP 0998-UC-0446HXX; ... This ...
(Date:6/14/2017)... June 14, 2017 The Bio Supply Management ... City of Fremont and the Biomedical Manufacturing ... industry in California by providing ... networking, and fostering workforce development. The primary focus of ... of start-ups, as well as small and mid-sized biomedical ...
Breaking Medicine Technology:
Cached News: