HOME >> MEDICINE >> NEWS
Short sugar chains-a future drug for Alzheimer's?

Heparansulfate, which is needed for normal fetal development among other things, is also important for the build-up of amyloid, morbid protein deposits that appear in several serious diseases. This is shown by Uppsala scientists in an article published in today's Net edition of the U.S. journal Proceedings of the National Academy of Science.

Heparansulfate, long chains of sugar molecules, is produced by most cells in the body. It was not previously known that heparansulfate is necessary for the occurrence of amyloid, abnormal protein deposits in the body. Amyloid appears in several grave disorders, such as Alzheimer's disease, mad-cow disease, old-age diabetes, and so-called AA amyloidosis, which often develops in chronic inflammatory diseases.

The research team is headed by Professor Ulf Lindahl and Associate Professor Jin-ping Li at the Department of Medical Biochemistry and Microbiology at Uppsala University. They have studied how heparansulfate binds the abnormal protein molecules and thereby triggers amyloid deposits. In experiments the researchers have used genetically altered mice that produce much higher than normal amounts of the enzyme heparanase. This enzyme cuts the normal-length heparansulfate chain into short segments. Both the genetically altered and the normal control mice were stimulated with a treatment that usually leads to rapid build-up of amyloid (AA amyloidosis) in several internal organs, including the liver, the kidneys, and the spleen. The heparanase-producing mice proved to be completely resistant to amyloidosis of the liver and kidneys, organs with pronounced overproduction of the enzyme and therefore very short heparansulfate fragments. On the other hand, they did develop amyloid in the spleen, which had avoided overproduction of heparanase and therefore contained normal size heparansulfate. The control mice developed amyloidosis of the spleen and of the liver and kidneys. The findings indicate that the occurrence of
'"/>

Contact: Anneli Waara
anneli.waara@uadm.uu.se
46-18-471-1974
Swedish Research Council
19-Apr-2005


Page: 1 2

Related medicine news :

1. Shorter post-operative recovery stay following outpatient tonsillectomy is safe, cost-efficient
2. Short episodes of manic symptoms may indicate bipolar disorder in some youth
3. Short-term topical corticosteroid use may offer relief for patients with acute form of psoriasis
4. Shorter distance on six-minute walk test points up a greater risk of death
5. Short-term intervention programs have potential to reduce teen methamphetamine use
6. Short term follow-up proves to be helpful
7. Short glasses more likely to lead to over-indulgence
8. Short-term survival rates better for US vs. Canadian heart failure patients
9. Shortness of breath without chest pain can signify the presence of high risk heart disease
10. Short-term hormone therapy can improve outlook for men with early prostate cancer
11. Shorter course of radiotherapy effective for palliation of painful bone metastases

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Short sugar chains future drug for Alzheimer

(Date:4/18/2015)... April 18, 2015 Carinsurancesavings.biz has released ... plans are cheaper during Spring. , Spring ... insurance plan. Drivers should make sure they compare the ... vehicles. Clients can learn more about Spring car insurance ... , Auto insurance quotes are becoming more and more ...
(Date:4/18/2015)... PA (PRWEB) April 18, 2015 "I ... evacuation stretchers in healthcare facilities," said an inventor from ... alternative storage system." , He developed the Slyde Door ... doors used in healthcare facilities. It provides convenient storage ... there are more stretchers available for patients. , ...
(Date:4/18/2015)... April 18, 2015 Review of Ophthalmology ... a ‘Strategies for Success’ program for cataract surgeons attending ... in San Diego, where eye surgeon Jeffrey L. Martin, ... invitation-only event. Dr. Martin is the Managing Partner of ... Ophthalmology chose Dr. Martin to lead this year’s discussion ...
(Date:4/18/2015)... (PRWEB) April 18, 2015 Lowcostcarinsuranceprice.com has ... theft rates have on auto insurance prices . ... high rates of vehicle theft may have to pay ... Some liability auto insurance policies can also offer protection ... can now be compared online on a single website: ...
(Date:4/18/2015)... NC (PRWEB) April 18, 2015 Patients ... risk of developing mesothelioma later in life, but the ... from mesothelioma that is unrelated to radiation. Surviving Mesothelioma ... on its website. Click here to read it ... Australia compared the cases of 45 patients who had ...
Breaking Medicine News(10 mins):Health News:Auto Insurance Plans Are Cheaper During Spring! 2Health News:Dr. Jeffrey Martin Invited to Share Latest Breakthroughs in Cataract Care During Roundtable Discussion at National 2015 ASCRS Meeting In San Diego 2Health News:High Rates Of Car Theft Can Have An Impact on Auto Insurance Prices! 2Health News:New Study Examines Relationship Between Radiation for Hematologic Cancers and Development of Mesothelioma, According to Surviving Mesothelioma 2
(Date:4/17/2015)... HILL, N.C. , April 17, 2015  Regulatory ... the newly released bipartisan discussion draft called "21 st ... document is planned to be taken up by Congress ... how pharmaceutical and medical device products are developed and ... For that reason, many companies have begun to consider ...
(Date:4/17/2015)... Nonin Medical, a global leader in noninvasive medical monitoring, ... Steve Bucholz will retire May 1. Company founder ... Chief Executive Officer. In addition, Mr. Isaacson will continue ... transition to David Noel , Chief Financial Officer. ... to Nonin Medical,s growth," Mr. Isaacson said. "Under Steve,s ...
(Date:4/17/2015)... Research and Markets ( http://www.researchandmarkets.com/research/lmsnqn/medical_equipment ) ... Rental and Leasing - Global Strategic Business Report" ... the worldwide markets for Medical Equipment Rental and Leasing ... for the US, Japan , ... Annual estimates and forecasts are provided for the ...
Breaking Medicine Technology:21st Century Cures: A Regulatory Game-Changer for the Pharmaceutical Industry 2Nonin Medical's Philip Isaacson Expands CEO Role; President and COO Steve Bucholz to Retire May 1 2Medical Equipment Rental and Leasing Market 2015-2020 - Global Strategic Business Report - Healthcare Spending Slowdown Bodes Well for Medical Equipment Leasing 2
Cached News: