HOME >> MEDICINE >> NEWS
Short sugar chains-a future drug for Alzheimer's?

Heparansulfate, which is needed for normal fetal development among other things, is also important for the build-up of amyloid, morbid protein deposits that appear in several serious diseases. This is shown by Uppsala scientists in an article published in today's Net edition of the U.S. journal Proceedings of the National Academy of Science.

Heparansulfate, long chains of sugar molecules, is produced by most cells in the body. It was not previously known that heparansulfate is necessary for the occurrence of amyloid, abnormal protein deposits in the body. Amyloid appears in several grave disorders, such as Alzheimer's disease, mad-cow disease, old-age diabetes, and so-called AA amyloidosis, which often develops in chronic inflammatory diseases.

The research team is headed by Professor Ulf Lindahl and Associate Professor Jin-ping Li at the Department of Medical Biochemistry and Microbiology at Uppsala University. They have studied how heparansulfate binds the abnormal protein molecules and thereby triggers amyloid deposits. In experiments the researchers have used genetically altered mice that produce much higher than normal amounts of the enzyme heparanase. This enzyme cuts the normal-length heparansulfate chain into short segments. Both the genetically altered and the normal control mice were stimulated with a treatment that usually leads to rapid build-up of amyloid (AA amyloidosis) in several internal organs, including the liver, the kidneys, and the spleen. The heparanase-producing mice proved to be completely resistant to amyloidosis of the liver and kidneys, organs with pronounced overproduction of the enzyme and therefore very short heparansulfate fragments. On the other hand, they did develop amyloid in the spleen, which had avoided overproduction of heparanase and therefore contained normal size heparansulfate. The control mice developed amyloidosis of the spleen and of the liver and kidneys. The findings indicate that the occurrence of
'"/>

Contact: Anneli Waara
anneli.waara@uadm.uu.se
46-18-471-1974
Swedish Research Council
19-Apr-2005


Page: 1 2

Related medicine news :

1. Shorter post-operative recovery stay following outpatient tonsillectomy is safe, cost-efficient
2. Short episodes of manic symptoms may indicate bipolar disorder in some youth
3. Short-term topical corticosteroid use may offer relief for patients with acute form of psoriasis
4. Shorter distance on six-minute walk test points up a greater risk of death
5. Short-term intervention programs have potential to reduce teen methamphetamine use
6. Short term follow-up proves to be helpful
7. Short glasses more likely to lead to over-indulgence
8. Short-term survival rates better for US vs. Canadian heart failure patients
9. Shortness of breath without chest pain can signify the presence of high risk heart disease
10. Short-term hormone therapy can improve outlook for men with early prostate cancer
11. Shorter course of radiotherapy effective for palliation of painful bone metastases

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/25/2016)... ... June 25, 2016 , ... Experts ... applications at AcademyHealth’s Annual Research Meeting June 26-28, 2016, at the Hynes Convention ... health care topics including advance care planning, healthcare costs and patient and family ...
(Date:6/25/2016)... ... 2016 , ... First Choice Emergency Room , the largest network of ... Medical Director of its new Mesquite-Samuell Farm facility. , “We are pleased to ... said Dr. James M. Muzzarelli, Executive Medical Director of First Choice Emergency Room. ...
(Date:6/25/2016)... ... ... Conventional wisdom preaches the benefits of moderation, whether it’s a matter of ... too high can result in disappointment, perhaps even self-loathing. However, those who set the ... Research from PsychTests.com reveals that behind the tendency to set low expectations ...
(Date:6/24/2016)... ... ... in a crisis. Her son James, eight, was out of control. Prone to extreme mood ... something upset him, he couldn’t control his emotions,” remembers Marcy. “If there was a ... children and say he was going to kill them. If we were driving on ...
(Date:6/24/2016)... Diego, CA (PRWEB) , ... June 24, 2016 , ... ... with the American Cancer Society and the Road To Recovery® program to drive cancer ... to seniors and other adults to ensure the highest quality of life and ongoing ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... , June 27, 2016 Jazz Pharmaceuticals ... waiting period under the Hart-Scott-Rodino Antitrust Improvements Act of ... acquisition of Celator Pharmaceuticals, Inc. ("Celator"; Nasdaq: ... p.m. (Eastern Daylight Time). As previously announced ... into a definitive merger agreement under which Jazz Pharmaceuticals ...
(Date:6/26/2016)... , June 26, 2016 ... care operating models within the health care industry is ... financial efficiency , Deloitte offers a suite of ... business issues impacting efficient cost optimization: labor resource analysis, ... These services facilitate better outcomes and better economics ...
(Date:6/24/2016)... OAKLAND, N.J. , June 24, 2016 /PRNewswire/ ... in the design, development and manufacturing of collagen ... and regeneration announced today that Bill Messer ... Sales and Marketing to further leverage the growing ... surgery medical devices. Bill joins the ...
Breaking Medicine Technology:
Cached News: