HOME >> MEDICINE >> NEWS
'Smart' mice teach scientists about learning process, brain disorders

DALLAS May 27, 2007 -- Mice genetically engineered to lack a single enzyme in their brains are more adept at learning than their normal cousins, and are quicker to figure out that their environment has changed, a team led by researchers at UT Southwestern Medical Center has found.

The results, appearing today in the online edition of the journal Nature Neuroscience, reveal a new mechanism of learning in the brain, which might serve in humans as a target for treating disorders such as post-traumatic stress disorder, Alzheimers disease or drug addiction, the researchers said.

"Its pretty rare that you make mice smarter, so there are a lot of cognitive implications," said Dr. James Bibb, assistant professor of psychiatry and the studys senior author.

"Everything is more meaningful to these mice," he said. "The increase in sensitivity to their surroundings seems to have made them smarter."

The engineered mice were more adept at learning to navigate a water maze and remembering that being in a certain box involves a mild shock. Equally important, Dr. Bibb said, when a situtation changed, such as the water maze being rearranged, the engineered mice were much faster to realize that things were different and work out the new route.

Dr. Bibb cautioned that while the mice learn faster, studies on the long-term effects of deleting the enzyme, called Cdk5, from the brain are continuing.

The group is also beginning a search for drugs that might create the same effects without genetic manipulation and monitoring the animals health and behavior over time.

The findings may have applications in treating post-traumatic stress disorder, where getting a patient to learn that a once-threatening situation no longer poses a danger is a major goal.

In addition, Cdk5 is heavily implicated in Alzheimers disease and addiction to drugs of abuse, so understanding how the enzyme affects the brain and
'"/>

Contact: Aline McKenzie
aline.mckenzie@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
27-May-2007


Page: 1 2

Related medicine news :

1. Smart sunglasses and goggles let users adjust shade and color
2. Smart buildings to guide future first responders
3. Next generation of Latino drug abuse experts at UH to learn, teach
4. Resident work hour restrictions may be costly for teaching hospitals
5. Northwestern surgeon invents teaching technology for scary patient exams
6. Alcohol interventions that teach practical skills work best with high-risk university students
7. Do patients in teaching hospitals get better care?
8. M. D. Anderson teaches the art of aromatherapy to soothe and heal
9. Strategies that teach a caregiver to manage a loved ones illness also helps in coping with death
10. HIV risks reduced when mothers teach daughters about disease
11. Three Pitt teacher-scholars honored by NSF with CAREER awards

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/24/2017)... (PRWEB) , ... February 24, 2017 , ... With ProGlass ... Cut Pro X . Users have total control over position, rotation, distortion, edge softness, ... all within Final Cut Pro X. , With ProGlass Prism users are given the ...
(Date:2/24/2017)... ... ... The Radiology Business Management Association will select the 2017 ... Building Better Radiology Marketing Programs conference, held this year from March 5 to ... are given out in five categories. They are:, ,     Patient Marketing, ...
(Date:2/23/2017)... ... 23, 2017 , ... On February 22, 2017 the U.S. ... to withdraw previous guidance issued by the Obama Administration requiring schools to treat ... 2016 by the Obama Administration came in response to a growing number of ...
(Date:2/23/2017)... Angeles, CA (PRWEB) , ... February 23, 2017 , ... ... first two episodes of WE TV’s “Mama June: From Not to Hot,” which will ... TV notable, “Mama” June Shannon, known to millions from the 2012 reality television series, ...
(Date:2/23/2017)... (PRWEB) , ... February 23, 2017 , ... Dr. David ... in Henderson, NV 89052. Dr. Mahon was named a 2017 Top Patient Rated ... is an online directory that recognizes local physicians and dentists who have earned ...
Breaking Medicine News(10 mins):
(Date:2/23/2017)... Südkorea, 23. Februar 2017 LG Innotek hat ... vorgestellt. Die Sterilisationsleistung beträgt das 1,5-fache des 45-mW-Moduls der ... im Bereich zwischen 200 und 280 nm und eignet sich ... indem es ihre DNA zerstört. Das Produkt von LG ... ...
(Date:2/23/2017)... and Markets has announced the addition of the "Menopause Drugs Price ... ... Analysis and Strategies - 2016, provides drug pricing data and benchmarks in ... What are the key drugs marketed for Menopause ... market? What are the unit prices and annual treatment ...
(Date:2/23/2017)... REDWOOD CITY, Calif. , Feb. 23, 2017 ... specialty pharmaceutical company focused on the development and ... moderate-to-severe acute pain, announced that it will release ... close on Thursday, March 2nd, 2017. AcelRx management ... p.m. Eastern Time (1:30 p.m. Pacific Time) on ...
Breaking Medicine Technology:
Cached News: