HOME >> MEDICINE >> NEWS
'Smart' mice teach scientists about learning process, brain disorders

DALLAS May 27, 2007 -- Mice genetically engineered to lack a single enzyme in their brains are more adept at learning than their normal cousins, and are quicker to figure out that their environment has changed, a team led by researchers at UT Southwestern Medical Center has found.

The results, appearing today in the online edition of the journal Nature Neuroscience, reveal a new mechanism of learning in the brain, which might serve in humans as a target for treating disorders such as post-traumatic stress disorder, Alzheimers disease or drug addiction, the researchers said.

"Its pretty rare that you make mice smarter, so there are a lot of cognitive implications," said Dr. James Bibb, assistant professor of psychiatry and the studys senior author.

"Everything is more meaningful to these mice," he said. "The increase in sensitivity to their surroundings seems to have made them smarter."

The engineered mice were more adept at learning to navigate a water maze and remembering that being in a certain box involves a mild shock. Equally important, Dr. Bibb said, when a situtation changed, such as the water maze being rearranged, the engineered mice were much faster to realize that things were different and work out the new route.

Dr. Bibb cautioned that while the mice learn faster, studies on the long-term effects of deleting the enzyme, called Cdk5, from the brain are continuing.

The group is also beginning a search for drugs that might create the same effects without genetic manipulation and monitoring the animals health and behavior over time.

The findings may have applications in treating post-traumatic stress disorder, where getting a patient to learn that a once-threatening situation no longer poses a danger is a major goal.

In addition, Cdk5 is heavily implicated in Alzheimers disease and addiction to drugs of abuse, so understanding how the enzyme affects the brain and
'"/>

Contact: Aline McKenzie
aline.mckenzie@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
27-May-2007


Page: 1 2

Related medicine news :

1. Smart sunglasses and goggles let users adjust shade and color
2. Smart buildings to guide future first responders
3. Next generation of Latino drug abuse experts at UH to learn, teach
4. Resident work hour restrictions may be costly for teaching hospitals
5. Northwestern surgeon invents teaching technology for scary patient exams
6. Alcohol interventions that teach practical skills work best with high-risk university students
7. Do patients in teaching hospitals get better care?
8. M. D. Anderson teaches the art of aromatherapy to soothe and heal
9. Strategies that teach a caregiver to manage a loved ones illness also helps in coping with death
10. HIV risks reduced when mothers teach daughters about disease
11. Three Pitt teacher-scholars honored by NSF with CAREER awards

Post Your Comments:
(Date:10/22/2014)... October 22, 2014 Akeso Biomedical, ... for the treatment of bacterial infections, microbial biofilms, and ... joined its board of directors. , Dr. ... Systems at The Massachusetts Institute of Technology, or MIT. ... since 1968. Dr. Sinskey also holds positions as Co-Director ...
(Date:10/22/2014)... Salamon HealthDay Reporter , TUESDAY, ... vitro fertilization (IVF) are only about half as likely as ... technique, new research indicates, and the racial disparity persists even ... 31 percent of white patients became pregnant after IVF, compared ... than 4,000 IVF cycles over two years to tease out ...
(Date:10/22/2014)... Tara Haelle HealthDay Reporter ... among young adult men may lead to increased blood pressure, ... cause a similar rise in blood pressure for young adult ... when young adult women drank lightly or moderately, their risk ... found. "This finding parallels studies in older adult men ...
(Date:10/22/2014)... 2014 (HealthDay News) -- Measures taken by Firestone officials ... Liberia may have limited the spread of the disease ... The Firestone Natural Rubber Co. provides health services to ... nearby densely populated communities. Between Aug. 1 and ... cases among those 80,000 people. That incidence rate of ...
(Date:10/22/2014)... HealthDay Reporter TUESDAY, Oct. 21, 2014 (HealthDay ... working for NBC News in Liberia has cleared the ... at Nebraska Medical Center in Omaha, where he had been treated ... blood test confirmed by the U.S. Centers for Disease Control and ... R.I., NBC News reported Tuesday night. "Recovering from ...
Breaking Medicine News(10 mins):Health News:Akeso Biomedical Appoints Dr. Anthony J. Sinskey to Board of Directors 2Health News:Black Women Fare Worse With Fertility Treatments, Study Says 2Health News:Black Women Fare Worse With Fertility Treatments, Study Says 3Health News:Binge Drinking May Boost Blood Pressure in Young Men 2Health News:Binge Drinking May Boost Blood Pressure in Young Men 3Health News:Binge Drinking May Boost Blood Pressure in Young Men 4Health News:Tire Company Sets Standard for Ebola Care in Liberia: CDC 2Health News:U.S. Cameraman Treated for Ebola 'Free' of the Virus 2Health News:U.S. Cameraman Treated for Ebola 'Free' of the Virus 3
(Date:10/22/2014)... , Oct. 21, 2014   BioNano Genomics ... latest genomics research centers to purchase an ... the National Cancer Institute (NCI), NIH Intramural Sequencing ... Before Irys, obtaining a comprehensive view of a ... sequencing (NGS) does not deliver the scalability or ...
(Date:10/22/2014)... , Oct. 21, 2014 Influenza will affect ... deaths in the United States as ... are thought to spread is from person to person in ... has a serve way of death, but kills much fewer ... is also done by human fluids including sweat, saliva, blood ...
(Date:10/22/2014)... NEW YORK , Oct. 22, 2014 ... an August 2014 report by Global Research & Data ... 6.2% per year from 2014 through 2018, as demand ... United States is the world,s largest market ... market with advanced thermometers is Sanomedics International Holdings, Inc. ...
Breaking Medicine Technology:BioNano's Irys System Adopted by Leading Genomics Centers for Comprehensive Detection of Human Genome Structural Variation 2BioNano's Irys System Adopted by Leading Genomics Centers for Comprehensive Detection of Human Genome Structural Variation 3WholeHealth Products is proud to be releasing its Influenza A and B combo test, on the heels of the announcing of its phase 2 completion of the Rapid Ebola Test 2Sanomedics International Holdings Analyst Report: Taking Some Heat by BrokerBank Securities, Inc. 2
Cached News: