HOME >> MEDICINE >> NEWS
'Smart' mice teach scientists about learning process, brain disorders

DALLAS May 27, 2007 -- Mice genetically engineered to lack a single enzyme in their brains are more adept at learning than their normal cousins, and are quicker to figure out that their environment has changed, a team led by researchers at UT Southwestern Medical Center has found.

The results, appearing today in the online edition of the journal Nature Neuroscience, reveal a new mechanism of learning in the brain, which might serve in humans as a target for treating disorders such as post-traumatic stress disorder, Alzheimers disease or drug addiction, the researchers said.

"Its pretty rare that you make mice smarter, so there are a lot of cognitive implications," said Dr. James Bibb, assistant professor of psychiatry and the studys senior author.

"Everything is more meaningful to these mice," he said. "The increase in sensitivity to their surroundings seems to have made them smarter."

The engineered mice were more adept at learning to navigate a water maze and remembering that being in a certain box involves a mild shock. Equally important, Dr. Bibb said, when a situtation changed, such as the water maze being rearranged, the engineered mice were much faster to realize that things were different and work out the new route.

Dr. Bibb cautioned that while the mice learn faster, studies on the long-term effects of deleting the enzyme, called Cdk5, from the brain are continuing.

The group is also beginning a search for drugs that might create the same effects without genetic manipulation and monitoring the animals health and behavior over time.

The findings may have applications in treating post-traumatic stress disorder, where getting a patient to learn that a once-threatening situation no longer poses a danger is a major goal.

In addition, Cdk5 is heavily implicated in Alzheimers disease and addiction to drugs of abuse, so understanding how the enzyme affects the brain and
'"/>

Contact: Aline McKenzie
aline.mckenzie@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
27-May-2007


Page: 1 2

Related medicine news :

1. Smart sunglasses and goggles let users adjust shade and color
2. Smart buildings to guide future first responders
3. Next generation of Latino drug abuse experts at UH to learn, teach
4. Resident work hour restrictions may be costly for teaching hospitals
5. Northwestern surgeon invents teaching technology for scary patient exams
6. Alcohol interventions that teach practical skills work best with high-risk university students
7. Do patients in teaching hospitals get better care?
8. M. D. Anderson teaches the art of aromatherapy to soothe and heal
9. Strategies that teach a caregiver to manage a loved ones illness also helps in coping with death
10. HIV risks reduced when mothers teach daughters about disease
11. Three Pitt teacher-scholars honored by NSF with CAREER awards

Post Your Comments:
(Date:7/22/2014)... Garland’s new Energizer BK specially ... as a flood coat over new and existing asphalt ... restoration material. It provides natural resistance to moisture, chemicals, ... life-cycle costs. Energizer BK is specially formulated with an ... in addition to superior strength and flexibility. , ...
(Date:7/22/2014)... UT (PRWEB) July 22, 2014 Most people encounter ... is a weak appetite and the second is a fast metabolism. ... CB-1 Weight Gainer provides ways to help fight these problems ... of appetite. There are people out there who just can’t seem ... bites and then they are full. The cause of this problem ...
(Date:7/22/2014)... CA (PRWEB) July 22, 2014 The ... training, olympic weightlifting, plyometrics, powerlifting, gymnastics, kettleball lifting, calisthenics, ... workout. , Jason Sobzcak, co-owner of CrossFit ... EnergyFirst’s products because extreme workouts like these require ... Paleo diet so I need to take in about ...
(Date:7/21/2014)... (PRWEB) July 22, 2014 Recently, Stwd.co.uk, a ... of cheap wedding dresses. Additionally, the company’s chief executive officer ... at discounted prices, up to 58% off. , “All our ... The special offer is launched to bring huge benefits to ... collection of cheap wedding outfits. By the way, we offer ...
(Date:7/21/2014)... 2014 PowerObjects, a professional services ... and add-ons for Microsoft Dynamics CRM, has joined ... elite group of the most strategic Microsoft Dynamics ... that rank them in the highest echelon of ... of the Microsoft Dynamics Inner Circle have performed ...
Breaking Medicine News(10 mins):Health News:Energizer® BK Waterproof Coating from Garland Canada Reduces Life-Cycle Costs 2Health News:CB-1 Weight Gainer Provides Two Tips to Help Customers Gain Weight 2Health News:CrossFit East Cobb Fuels Their Intense Workouts with All-Natural EnergyFirst Supplements 2Health News:CrossFit East Cobb Fuels Their Intense Workouts with All-Natural EnergyFirst Supplements 3Health News:2014 Cheap Wedding Dresses, Newest Items Offered by Professional Company Stwd.co.uk 2Health News:PowerObjects Joins the 2014 Microsoft Dynamics Inner Circle 2
(Date:7/21/2014)... , July 21, 2014 McCord Research, ... (U.S. Patent No. 8,796,315). This patent describes a ... healing.  According to the inventor, Dr. McCord, this ... require wound healing, a composition of an effective ... from umbilical cord blood, such that the administration ...
(Date:7/21/2014)... -- Nitrosolution.com, a website that features safe and all-natural ... anniversary in August. The online retailer specializes in an ... ability to produce nitric oxide. Called Nitroxyl, it is ... variety of phytonutrients and other natural ingredients that a ... nitric oxide production in the arteries and brain. ...
(Date:7/21/2014)... , July 21, 2014  Champions Oncology (OTC: ... technology solutions and services to personalize the development and ... its financial and operational results for the fourth quarter ... July 24, 2014, after market close. The ... results that day at 4:30 p.m. EDT (1:30 p.m. ...
Breaking Medicine Technology:US Patent Office Grants McCord Research Endothelial Cell Treatment Patent 2Up and Coming Nitric Oxide Supplements Company Nitrosolution.com Celebrates its One Year Anniversary 2
Cached News: