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Smoking associated with severity of psoriasis

Cigarette smoking is associated with the clinical severity of the skin disease psoriasis, and both smoking and obesity are more prevalent among psoriasis patients, according to two studies in the December issue of Archives of Dermatology, one of the JAMA/Archives journals.

Psoriasis is a chronic, persistent, lifelong disease characterized by scaly red plaques on the surface of the skin. Although psoriasis is not a life-threatening disease, the disability experienced by patients with psoriasis is comparable with that of patients with other chronic illnesses, such as heart disease, diabetes, cancer, and depression, according to background information in the article. Cigarette smoking is a risk factor for many chronic diseases, including psoriasis, but little is known about the effect of smoking on psoriasis severity.

Cristina Fortes, Ph.D., of Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy, and colleagues conducted a cross-sectional study to evaluate the association between different components of smoking history and the clinical severity of psoriasis. They analyzed data on 818 adults with psoriasis in inpatient wards of a hospital for skin diseases.

"Specifically, patients who smoked more than a pack of cigarettes (more than 20 cigarettes) daily had twice the risk of more severe psoriasis compared with those who smoked ten cigarettes or less per day," the authors report.

Cigarette-years, measured as the product of the intensity and duration of smoking, significantly increased the risk of clinically more severe psoriasis. "Separate analyses for men and women showed that the effect of cigarette-years on psoriasis severity was stronger for women than for men," the authors write.

"Smoking is associated with the clinical severity of psoriasis and highlights the importance of smoking cessation in patients with psoriasis," they conclude. (Arch Dermatol. 2005;141:1580-1584. Available pre-embargo to the media at
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Contact: Cristina Fortes, Ph.D.
c.fortes@idi.it
JAMA and Archives Journals
19-Dec-2005


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