Speeding 'fingertip' discovery -- 20 years of protein info in 1 place

Researchers at Johns Hopkins took advantage of a new technique that reads the makeup of proteins to identify nearly all chemical changes nature makes by adding phosphate to proteins manufactured in human cells.

The Hopkins team then added its list of these so-called phosphorylation events to lists compiled by others and created a publicly available database on the Web - PhosphoMotif Finder [ http://www.hprd.org/PhosphoMotif_finder ] - to help speed the work of researchers around the world.

Finding so many at one time is a huge advance, says Akhilesh Pandey, M.D., Ph.D., an associate professor at the McKusick-Nathans Institute of Genetic Medicine at Hopkins. Phosphorylation is essential for controlling chemical reactions in our cells protein factories, and phosphorylation gone awry has been implicated in several diseases. The ability to study more than one phosphorlyation at a time will help us understand some of these diseases - including cancers - sooner.

What we have here is about 20 years worth of lots of work in one searchable list, says Pandey. A report on all of the newly identified protein alterations is published in the Feb. 13 issue of the Proceedings of the National Academy of Sciences, while a report on the database appears in the March issue of Nature Biotechnology.

Pandeys team used electron transfer dissociation (ETD) tandem mass spectrometry, a technology that breaks apart proteins into small fragments, separates them by size and identifies the fragments based on their mass - their size and weight. The process improves on previous techniques by breaking up proteins more gently and keeping chemical modifications like phosphorylation intact. Previous spectrometry methods were just too rough on the delicate protein alterations and sheared them right off, he says. We had to guess where they might be and nobody wants to chase false leads based on wrong gues

Contact: Audrey Huang
Johns Hopkins Medical Institutions

Page: 1 2

Related medicine news :

1. Speeding up CT scans with cellphone technology, ultrasound warning signal for breast cancer
2. Jefferson pharmacologist says biomarker discovery bodes well for better cancer diagnostics
3. Major discovery raises prospect of better patient care by improving platelet life span
4. African scientists will train at Emory University in latest drug discovery techniques
5. Gene chip discovery may lead to individualized treatment for 5 hereditary liver diseases
6. More insight into Alzheimers disease with Stanford discovery of possible cause
7. Hope for significant new diabetes treatment in Stanford discovery
8. BC catalyst discovery promises faster, cheaper drug production
9. New sleep gene discovery wakes up scientists
10. Mouse model aids discovery of novel melanoma metastasis gene
11. Turning the tables on drug discovery

Post Your Comments:

(Date:11/25/2015)... Rouge, LA (PRWEB) , ... November 25, 2015 , ... ... in the United States District Court of Connecticut on behalf of a home health ... behalf of all current or former home health care workers employed by Humana, Inc., ...
(Date:11/25/2015)... ... 2015 , ... Dental professionals who would like to become more proficient on ... Dr. Mark Iacobelli’s Advanced Implant Mentoring (AIM) CE course. Courses will be held on ... co-founders of Advanced Implant Mentoring (AIM), Dr. Iacobelli and Dr. D’Orazio are proud to ...
(Date:11/25/2015)... ... 2015 , ... On November 23rd 2015 Cozy Products, a division ... business. Cozy Products explains what this means for business moving forward. , The Tri ... Products business model: to sell personal heaters that reduce energy consumption, are economical and ...
(Date:11/25/2015)... Evanston, IL (PRWEB) , ... November 25, 2015 ... ... homage to six decades of music, friendships, and learning in its 65th Anniversary ... be held Dec. 5-6. , For 65 years, Brillianteen has been ...
(Date:11/25/2015)... Missouri (PRWEB) , ... November 25, 2015 , ... ... HEAL, will provide scholarships for people struggling with eating disorders as a result ... from the second annual event, held at Fox Run Golf Club in Eureka, ...
Breaking Medicine News(10 mins):
(Date:11/25/2015)... , Nov. 25, 2015 AAIPharma ... planned investment of at least $15.8  Million to ... Wilmington, NC . The expansion will ... to meet the growing demands of the pharmaceutical ... site expansion will provide up to 40,000 ...
(Date:11/25/2015)... -- Henry Schein, Inc., the world,s largest provider of health ... animal health practitioners, will unveil at the Greater New ... Pavilion , which brings together for the first time ... help any practice or laboratory enter the digital age. ... of experts appearing at the Pavilion. --> ...
(Date:11/25/2015)... 25, 2015  Trovagene, Inc. (NASDAQ: TROV ), ... Chief Executive Officer Antonius Schuh, Ph.D., is scheduled to ... Annual Piper Jaffray Healthcare Conference. th ... Palace Hotel in New York ... Mr. Schuh will be available for one-on-one meetings during ...
Breaking Medicine Technology:
Cached News: