HOME >> MEDICINE >> NEWS
Stanford researchers identify immune dysfunction in melanoma patients

STANFORD, Calif. -- Researchers at the Stanford University School of Medicine have begun to shed light on why the human immune system isn't able to stop such cancers as melanoma, suggesting answers that could pave the way for better treatment of this often-fatal illness.

In a small study, the scientists found that the immune cells in a majority of people with this deadly skin cancer fail to respond properly to a molecule called interferon, which normally activates the immune system. Without the ability to respond to interferon, the cells are less able to fend off the cancer, according to the study that will be published in the May issue of Public Library of Science-Medicine.

These results help explain a decade of research showing that people with cancer often have dysfunctional immune systems. Until now, researchers could tell that the immune system wasn't working properly but didn't know which genes or pathways were involved in that failure. Finding the disruption in the cancer cells' interferon response could help in the development of vaccines to treat cancers.

"We think this is a dominant way that immune dysfunction occurs in people with cancer," said senior author Peter Lee, MD, associate professor of medicine.

Lee was interested in melanoma rather than other forms of cancer in part because of the deadly nature of the disease, which will kill about one in six of the 47,700 people it is expected to strike this year. Unless melanoma is caught early and removed, there is no effective treatment, although research groups have been testing vaccine therapies for the disease. However, Lee worried that unless researchers better understood immune dysfunctions in those people, the vaccines would have a low probability of success. "If you don't address the underlying immune defects, then vaccines won't do any good," Lee said.

The group started by separating out the four major types of immune cells from people with melano
'"/>

Contact: Amy Adams
amyadams@stanford.edu
650-723-3900
Stanford University Medical Center
7-May-2007


Page: 1 2 3

Related medicine news :

1. Stanford researchers find culprit in aging muscles that heal poorly
2. Old McDonalds has a hold on kids taste buds, Stanford/Packard study finds
3. Aging stem cells in mice may hold answers to diseases of the aged, Stanford study finds
4. Stanford researchers track human stem cells transplanted into rat brain
5. Once-fatal metabolic disorders treatable, says Stanford/Packard researcher
6. Tiny newborns face higher risk of death at community hospitals, Stanford/VA study finds
7. Star Trek-type scanning may reveal genetic activity of tumors, Stanford study shows
8. Scavenger cells may have role blocking obesity, Stanford study shows
9. Eye diseases gave great painters different vision of their work, Stanford ophthalmologist says
10. IADR presents Research in Prosthodontics & Implants Award to Stanford
11. Insight on fruit fly immune system could lead to new types of vaccines, Stanford researchers say

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/22/2017)... ... ... “Glimpses Of Light”: is a unique and thought inspiring guide toward ... of published author, J.M. Shepherd, a writer, teacher, traveler, and metaphysician, the author has ... Shepherd shares, “Love is one of the least understood and yet most sought-after pleasures ...
(Date:8/22/2017)... ... August 22, 2017 , ... “Call Of Spiritual Duty”: a revelation in an ... author, C.S. Lizarde. Growing up on the streets of North Visalia, California, Carlos ... to apply the Biblical keys to his life, he noticed immediately that opportunities and ...
(Date:8/21/2017)... , ... August 22, 2017 , ... ... not without risk to health and safety. By learning and implementing best practices ... , In this webinar, attendees will gain a better understanding of a ...
(Date:8/21/2017)... Viejo, CA (PRWEB) , ... August 21, 2017 , ... ... Film Studios. Editors can quickly and easily add washed color grades to footage. ... image. The LUT changes every pixel’s color to the corresponding color indicated by the ...
(Date:8/21/2017)... ... August 21, 2017 , ... Marathon running has surged in ... , Outdoor running increases exposure to ultraviolet radiation, a carcinogen that promotes skin ... and only half may be adequately protecting themselves with proper clothing and sunscreen. ...
Breaking Medicine News(10 mins):
(Date:7/31/2017)... TORONTO , July 31, 2017 7D Surgical, ... Spartan Medical has purchased the 7D Surgical System to support ... Washington D.C. and Virginia.  7D Surgical ... Medical for many of the premier medical facilities within those ... ...
(Date:7/28/2017)... July 28, 2017 EnvoyHealth, a Diplomat company, has ... program for CleverCap LITE, a technology designed to improve ... deliver innovative health technology solutions and services that help ... CleverCap LITE offers medication monitoring and ... cover: Records date ...
(Date:7/27/2017)... 2017  West Pharmaceutical Services, Inc. (NYSE: ... second-quarter 2017 and updated financial guidance for the full-year ... Highlights Reported net sales of $397.6 ... quarter. Net sales at constant currency (organic) grew by ... $0.51, compared to $0.60 in the prior-year quarter. Second-quarter ...
Breaking Medicine Technology:
Cached News: