HOME >> MEDICINE >> NEWS
Stanford researchers identify immune dysfunction in melanoma patients

STANFORD, Calif. -- Researchers at the Stanford University School of Medicine have begun to shed light on why the human immune system isn't able to stop such cancers as melanoma, suggesting answers that could pave the way for better treatment of this often-fatal illness.

In a small study, the scientists found that the immune cells in a majority of people with this deadly skin cancer fail to respond properly to a molecule called interferon, which normally activates the immune system. Without the ability to respond to interferon, the cells are less able to fend off the cancer, according to the study that will be published in the May issue of Public Library of Science-Medicine.

These results help explain a decade of research showing that people with cancer often have dysfunctional immune systems. Until now, researchers could tell that the immune system wasn't working properly but didn't know which genes or pathways were involved in that failure. Finding the disruption in the cancer cells' interferon response could help in the development of vaccines to treat cancers.

"We think this is a dominant way that immune dysfunction occurs in people with cancer," said senior author Peter Lee, MD, associate professor of medicine.

Lee was interested in melanoma rather than other forms of cancer in part because of the deadly nature of the disease, which will kill about one in six of the 47,700 people it is expected to strike this year. Unless melanoma is caught early and removed, there is no effective treatment, although research groups have been testing vaccine therapies for the disease. However, Lee worried that unless researchers better understood immune dysfunctions in those people, the vaccines would have a low probability of success. "If you don't address the underlying immune defects, then vaccines won't do any good," Lee said.

The group started by separating out the four major types of immune cells from people with melano
'"/>

Contact: Amy Adams
amyadams@stanford.edu
650-723-3900
Stanford University Medical Center
7-May-2007


Page: 1 2 3

Related medicine news :

1. Stanford researchers find culprit in aging muscles that heal poorly
2. Old McDonalds has a hold on kids taste buds, Stanford/Packard study finds
3. Aging stem cells in mice may hold answers to diseases of the aged, Stanford study finds
4. Stanford researchers track human stem cells transplanted into rat brain
5. Once-fatal metabolic disorders treatable, says Stanford/Packard researcher
6. Tiny newborns face higher risk of death at community hospitals, Stanford/VA study finds
7. Star Trek-type scanning may reveal genetic activity of tumors, Stanford study shows
8. Scavenger cells may have role blocking obesity, Stanford study shows
9. Eye diseases gave great painters different vision of their work, Stanford ophthalmologist says
10. IADR presents Research in Prosthodontics & Implants Award to Stanford
11. Insight on fruit fly immune system could lead to new types of vaccines, Stanford researchers say

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/19/2019)... ... 2019 , ... In one of the first research studies ... team led by a Worcester Polytechnic Institute professor found that women who experience ... weight gain during pregnancy, and weight retention after their baby is born. , ...
(Date:2/19/2019)... ... 19, 2019 , ... Pneumatic Vacuum Elevators, LLC has published ... on how-to make a house handicap accessible. , With this infographic , ... house handicap accessible. To accurately educate consumers on handicap accessibility, the infographic ...
(Date:2/19/2019)... ... February 19, 2019 , ... Hospice of Westchester (HOW) ... The funds will support the heart of its operation, the organization’s Home Care Services. ... years, and we are grateful for their ongoing generosity,” said Mary K. Spengler, MS, ...
(Date:2/19/2019)... ... February 19, 2019 , ... ... Endorsed Program that offers competitive student loan refinancing as a new member benefit. ... dentist may face. The average educational debt for all indebted graduates in the ...
(Date:2/19/2019)... ... February 19, 2019 , ... NCPDP announced today that ... patient engagement, will deliver the luncheon keynote on Tuesday, May 7, at ... medicine and empowering partnerships between patients and their medical providers to NCPDP’s Annual ...
Breaking Medicine News(10 mins):
(Date:2/19/2019)... ... February 19, 2019 , ... ... and the International Dyslexia Association estimates that there are 1 billion people with ... Global Search for Education and founder of CMRubinWorld, Fredrik Wetterhall, the co-founder of ...
(Date:2/19/2019)... ... February 19, 2019 , ... TopConsumerReviews.com recently gave its best-in-class 5 star ... prevent Lice. , Lice outbreaks are surprisingly common, especially in schools and other environments ... lice is not a sign of uncleanliness; in fact, lice prefer to live on ...
(Date:2/19/2019)... N.J. (PRWEB) , ... February ... ... applications and infrastructure solutions provider for global service providers, enterprises, and developers, ... and orchestration platform with the Arvizio MR Studio mixed reality visualization and ...
Breaking Medicine Technology:
Cached News: