HOME >> MEDICINE >> NEWS
Stanford snake venom study shows that certain cells may eliminate poison

e, sneezing, itching and red eyes. When they severely overreact, they can cause anaphylaxis, which can be fatal.

Given that tendency to overreact when stimulated by allergens, it seemed plausible that introducing venom into the body would trigger a similar response. But Galli and Martin Metz, MD, a postdoctoral scholar in pathology and first author of the study, have shown that when mast cells respond to selected venoms, they unleash proteins that break down some of the venoms' most toxic components.

The study was inspired by a 2004 paper in Nature, by Galli and a team of researchers including Metz, showing that mast cells reduced the mortality rate of mice suffering from bacterial peritonitis, a severe bacterial infection in the abdominal cavity that can also be fatal to humans. They found that mast cells released proteins that broke down a molecule called endothelin-1, one of the major toxins produced by the body during bacterial peritonitis or sepsis (bacterial infection in the blood).

In perusing the scientific literature, Metz noticed that endothelin-1 bore a striking similarity to sarafotoxin 6b, the most toxic component in the venom of the burrowing asp, or Israeli mole viper. Knowing also that mammalian mast cells had been shown to respond to many snake venoms by secreting some potent biologically active mediators, they hypothesized that mast cells might also act to degrade sarafotoxins and reduce the toxicity of the Israeli mole viper venom.

Galli and Metz first did experiments in vitro using isolated sarafotoxin 6b with mast cells from mice. "It worked as we thought it would," said Metz. The mast cells were activated, they released the expected proteins and the proteins degraded the sarafotoxin 6b. Mast cells also enhanced resistance of mice to sarafotoxin 6b when it was injected in vivo.

Next, Galli and Metz did experiments using the whole venom, not just the isolated toxin. Some of the mice they worked wi
'"/>

Contact: Louis Bergeron
louisb3@stanford.edu
650-725-2106
Stanford University Medical Center
27-Jul-2006


Page: 1 2 3 4

Related medicine news :

1. Stanford researchers find culprit in aging muscles that heal poorly
2. Old McDonalds has a hold on kids taste buds, Stanford/Packard study finds
3. Aging stem cells in mice may hold answers to diseases of the aged, Stanford study finds
4. Stanford researchers track human stem cells transplanted into rat brain
5. Once-fatal metabolic disorders treatable, says Stanford/Packard researcher
6. Tiny newborns face higher risk of death at community hospitals, Stanford/VA study finds
7. Star Trek-type scanning may reveal genetic activity of tumors, Stanford study shows
8. Scavenger cells may have role blocking obesity, Stanford study shows
9. Stanford researchers identify immune dysfunction in melanoma patients
10. Eye diseases gave great painters different vision of their work, Stanford ophthalmologist says
11. IADR presents Research in Prosthodontics & Implants Award to Stanford

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/23/2017)... YORK, NY (PRWEB) , ... May 23, 2017 ... ... makers in the pharmaceutical and medical device sectors, today announced the winners of ... Transformers • Entrepreneurs) represent the most influential people in the healthcare industry today. ...
(Date:5/23/2017)... ... May 23, 2017 , ... The ... professionals, is pleased to announce the organization’s Certified Strength Coach credential has earned ... Strength Coach (CSC) program validates the competency of qualified candidates for jobs in ...
(Date:5/23/2017)... ... May 23, 2017 , ... Drs. ... on peri-implantitis in Las Vegas, NV, and the importance of treating ... disease consultation and leading care for peri-implantitis, with or without a referral. As ...
(Date:5/23/2017)... Boston, MA (PRWEB) , ... May 23, 2017 , ... ... workshop on Tuesday, May 23, 2017 in San Francisco. Titled Connected Health and ... Premier Connected Home Event hosted by Parks Associates, a market research and consulting ...
(Date:5/23/2017)... , ... May 23, 2017 , ... Patients in need ... Dr. Angela Cotey’s practice to schedule an appointment, with or without a referral. Dr. ... offers pulpotomy treatments to pediatric patients as a healthy alternative to a tooth extraction. ...
Breaking Medicine News(10 mins):
(Date:5/10/2017)... CSSi, the global leader in patient recruitment, ... is proud to announce the launch of its newly ... both enriched content and a customized layout that provides ... already well-established position as the top global patient recruitment ... months of hard work, we are delighted to officially ...
(Date:5/8/2017)... -- MACRA replaces the outdated sustainable growth rate ... Black Book Research crowdsource-surveyed 8,845 physician practices from February ... for MIPS Compliance Technology is Booming ... or more clinicians seek to buy Merit-Based Incentive Payment ... of the changes, the hunt is on for the ...
(Date:5/4/2017)... 4, 2017  Fortuna Fix Inc. (" Fortuna "), ... first to eliminate the need for embryonic and fetal stem ... neurodegenerative diseases. Fortuna announced today the ... Michael Fehlings , MD, PhD; Father Kevin FitzGerald , ... and Professor James Giordano , PhD. "We ...
Breaking Medicine Technology:
Cached News: