HOME >> MEDICINE >> NEWS
Statins may simulate stem cells for heart repair

BUFFALO, N.Y. -- The drug pravastatin, which is used widely to decrease high cholesterol, may provide a previously unknown cardiovascular benefit in addition to lowering lipids.

Researchers at the University at Buffalo have found that pravastatin, the generic name of one of the statins currently prescribed to lower cholesterol, increased the concentration of endogenous stem cells that may participate in cardiac repair independent of any cholesterol-lowering action.

They also found that high doses of pravastatin improved cardiac function and coronary blood flow in an animal model in which flow had been artificially restricted, creating a condition known as hibernating myocardium. In this condition, heart cells reduce their function and oxygen needs and become dormant in response to insufficient blood flow.

Results of the study were presented today (Nov. 16, 2005) at the American Heart Association's 2005 Scientific Sessions in Dallas, Texas. "It is well known that stem cells have the potential to regenerate organs," said Gen Suzuki, M.D., Ph.D., research assistant professor in the UB School of Medicine and Biomedical Sciences and first author on the study.

"In the field of cardiology, adult stem cells isolated from bone marrow currently are being used to repair damaged heart tissue," Suzuki said. "Many animal and early clinical studies using this source of stem cells are ongoing right now."

Earlier reports have shown that HMG-CoA reductase inhibitors, known as statins, increased the number of circulating bone-marrow-derived or hematopoietic stem cells in blood, Suzuki said, but most work has focused on their effects in improving blood flow. Their localization in the heart or ability to increase cardiac-muscle-cell numbers has never been studied, he said.

The UB study employs a unique swine model of hibernating myocardium created by scientists in UB's Center for Research in Cardiovascular Medicine. Researchers treated no
'"/>

Contact: Lois Baker
ljbaker@buffalo.edu
716-645-5000 x1417
University at Buffalo
16-Nov-2005


Page: 1 2

Related medicine news :

1. Statins linked to lower risk of infection
2. Statins protect smokers from lung damage
3. Statins reduce risk of stroke in heart patients
4. Statins prove life-saving in patients with acute coronary syndromes
5. Statins may improve circulation in the retina
6. Statins, beta-blockers lessen heart attack risk, says Stanford-Kaiser study
7. Statins have neutral effect on risk of cancer
8. Statins reduce the risk of stroke and death after carotid artery surgery
9. Statins use associated with lower risk of fractures
10. Statins protect from death from pneumonia
11. Statins not associated with reduced dementia risk

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Statins may simulate stem cells for heart repair

(Date:9/4/2015)... ... 04, 2015 , ... Friday night, Chicago lovebirds Jenny McCarthy and Donnie Wahlberg ... Hope event supporting families affected by autism, raising nearly $250,000. , 150 guests, ... at the Oscar Swan Inn to support the cause. , McCarthy tugged the ...
(Date:9/3/2015)... ... 03, 2015 , ... TransPack Toon gives users a set of 90 cartoon ... framing transitions in 30 different styles. Presets range from snow, underwater, forest, futuristic, city ... TransPack Toon features 90 cartoon transitions from 30 unique styles. Editors can choose ...
(Date:9/3/2015)... ... September 03, 2015 , ... E-Volve ... a leading national healthcare solutions organization, to provide electronic medical record (EMR) consulting ... agreement, Amerinet members will receive negotiated pricing on E-Volve Health’s Epic EMR consulting, ...
(Date:9/3/2015)... ... September 03, 2015 , ... DriButts, a non-profit organization dedicated ... Product Development Group to manufacture a long-lasting reusable diaper for warm weather climates ... to bring 600 DriButts Diapers to rural areas of Haiti during a trip ...
(Date:9/3/2015)... ... September 03, 2015 , ... ... to be situated at 4400 Columbine Drive in Bellingham, Washington. Silverado Bellingham, a ... has been carefully designed to serve up to 80 people living with Alzheimer’s, ...
Breaking Medicine News(10 mins):Health News:Jenny McCarthy & Donnie Wahlberg Help Raise Over $200,000 For Generation Rescue’s ‘Night Of Hope’ Chicago Charity Event 2Health News:Pixel Film Studios Releases TransPack Toon, a New FCPX Transition 2Health News:E-Volve Health to Offer EMR Consulting Solutions to Amerinet Members 2Health News:DriButts Diapers Rely on Slingshot Help in Haiti 2Health News:DriButts Diapers Rely on Slingshot Help in Haiti 3Health News:Site Dedication Ceremony to Celebrate New Silverado Memory Care Community 2
(Date:9/3/2015)... Sept. 3, 2015 Report ... New Drugs, Industry Changes and Emerging Opportunities What,s ... ovaries? Visiongain,s new study forecasts those pharmaceutical revenues. ... that industry. You also explore trends, results, treatments, ... report gives revenue predictions to 2025 at overall ...
(Date:9/3/2015)... About self-monitoring blood glucose device ... device. It consists of a glucose sensor and ... through radiowaves from the sensor to a receiver, ... self-monitoring blood glucose devices can improve self-management of ... diabetes treatment. Technavio,s analysts forecast the ...
(Date:9/3/2015)... Nevro Corp. (NYSE: NVRO ), a ... solutions for the treatment of chronic pain, today announced ... Stanley Global Healthcare Conference on Thursday, September 17, 2015 ... is scheduled to present at 11:45 a.m. ET.  The ... accessible in the "Investors" section of the company,s website ...
Breaking Medicine Technology:Ovarian Cancer Drug Therapy: Companies, R&D and Revenue Forecasts 2015-2025: Recently Approved Treatments Give High Market Potential 2Ovarian Cancer Drug Therapy: Companies, R&D and Revenue Forecasts 2015-2025: Recently Approved Treatments Give High Market Potential 3Ovarian Cancer Drug Therapy: Companies, R&D and Revenue Forecasts 2015-2025: Recently Approved Treatments Give High Market Potential 4Ovarian Cancer Drug Therapy: Companies, R&D and Revenue Forecasts 2015-2025: Recently Approved Treatments Give High Market Potential 5Ovarian Cancer Drug Therapy: Companies, R&D and Revenue Forecasts 2015-2025: Recently Approved Treatments Give High Market Potential 6Global Self-monitoring Blood Glucose Devices Market 2015-2019 2
Cached News: