HOME >> MEDICINE >> NEWS
Statins may simulate stem cells for heart repair

BUFFALO, N.Y. -- The drug pravastatin, which is used widely to decrease high cholesterol, may provide a previously unknown cardiovascular benefit in addition to lowering lipids.

Researchers at the University at Buffalo have found that pravastatin, the generic name of one of the statins currently prescribed to lower cholesterol, increased the concentration of endogenous stem cells that may participate in cardiac repair independent of any cholesterol-lowering action.

They also found that high doses of pravastatin improved cardiac function and coronary blood flow in an animal model in which flow had been artificially restricted, creating a condition known as hibernating myocardium. In this condition, heart cells reduce their function and oxygen needs and become dormant in response to insufficient blood flow.

Results of the study were presented today (Nov. 16, 2005) at the American Heart Association's 2005 Scientific Sessions in Dallas, Texas. "It is well known that stem cells have the potential to regenerate organs," said Gen Suzuki, M.D., Ph.D., research assistant professor in the UB School of Medicine and Biomedical Sciences and first author on the study.

"In the field of cardiology, adult stem cells isolated from bone marrow currently are being used to repair damaged heart tissue," Suzuki said. "Many animal and early clinical studies using this source of stem cells are ongoing right now."

Earlier reports have shown that HMG-CoA reductase inhibitors, known as statins, increased the number of circulating bone-marrow-derived or hematopoietic stem cells in blood, Suzuki said, but most work has focused on their effects in improving blood flow. Their localization in the heart or ability to increase cardiac-muscle-cell numbers has never been studied, he said.

The UB study employs a unique swine model of hibernating myocardium created by scientists in UB's Center for Research in Cardiovascular Medicine. Researchers treated no
'"/>

Contact: Lois Baker
ljbaker@buffalo.edu
716-645-5000 x1417
University at Buffalo
16-Nov-2005


Page: 1 2

Related medicine news :

1. Statins linked to lower risk of infection
2. Statins protect smokers from lung damage
3. Statins reduce risk of stroke in heart patients
4. Statins prove life-saving in patients with acute coronary syndromes
5. Statins may improve circulation in the retina
6. Statins, beta-blockers lessen heart attack risk, says Stanford-Kaiser study
7. Statins have neutral effect on risk of cancer
8. Statins reduce the risk of stroke and death after carotid artery surgery
9. Statins use associated with lower risk of fractures
10. Statins protect from death from pneumonia
11. Statins not associated with reduced dementia risk

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Statins may simulate stem cells for heart repair

(Date:7/24/2014)... July 24, 2014 The Traffic ... training course designed to help users generate traffic and ... a buzz of excitement throughout the internet marketing community. ... attention of HonestyFirstReviews.com’s Tiffany Hendricks prompting a comprehensive review ... been involved in internet marketing will tell you, it ...
(Date:7/24/2014)... Voted one of the most reliable online ... focuses on providing its new and old customers with ... company has announced its new collection of high end ... created according to the latest fashion trends. Additionally, they ... off. , As a matter of fact, high end ...
(Date:7/24/2014)... 2014 Ticket Down is a reliable ... Denver at the Sports Authority Field on July 26th. For ... Challenge) has brought some of the best club teams from around ... Cup still being raved about weeks after its completion, fans – ... some of the biggest stars in the world compete. Some of ...
(Date:7/24/2014)... Park, NC (PRWEB) July 24, 2014 ... ethnic minorities, and low-income households are disproportionately affected ... public food safety net in the United States, ... , Under Section 743 of the Consolidated Appropriations ... Department of Agriculture's Food and Nutrition Service (FNS) ...
(Date:7/24/2014)... 2014 The report, “Content Delivery ... market into various sub-segments with an in-depth analysis ... drivers and restraints for this market with insights ... market data tables and 36 figures spread through ... Networks (CDN) Market” at http://www.marketsandmarkets.com/Market-Reports/content-delivery-networks-cdn-market-657.html . ...
Breaking Medicine News(10 mins):Health News:Traffic And Leads Training Academy - Review Examining Jeff Johnson’s New IM Course Released 2Health News:BellasDress Helps Brides Get High End Wedding Dresses for Their Romantic Weddings 2Health News:Manchester United vs. AS Roma Tickets Denver Sports Authority Field at Mile High: Ticket Down Cuts Ticket Prices for Guinness International Champions Cup Match 2Health News:Manchester United vs. AS Roma Tickets Denver Sports Authority Field at Mile High: Ticket Down Cuts Ticket Prices for Guinness International Champions Cup Match 3Health News:Report: Vulnerable Populations Disproportionately Affected by Food Security, Despite Public Programs 2Health News:Report: Vulnerable Populations Disproportionately Affected by Food Security, Despite Public Programs 3Health News:CDN Market by Delivery Technologies & Solutions Expected to Reach $12.16 Billion by 2019 - New Report by MarketsandMarkets 2Health News:CDN Market by Delivery Technologies & Solutions Expected to Reach $12.16 Billion by 2019 - New Report by MarketsandMarkets 3Health News:CDN Market by Delivery Technologies & Solutions Expected to Reach $12.16 Billion by 2019 - New Report by MarketsandMarkets 4
(Date:7/24/2014)... 24, 2014  Parnell Pharmaceuticals Holdings Ltd announces ... be added to Parnell,s already extensive pipeline through ... a biotechnology company. The compounds now known as ... in bone regeneration and dermal regeneration, respectively. Parnell ... for the veterinary market with the potential to ...
(Date:7/24/2014)... , July 24, 2014  PTC Therapeutics, Inc. (NASDAQ: ... will host a webcast conference call to report its ... on the company,s business and outlook on Thursday, August ... of the market. The call can ... 935-8152 (international) five minutes prior to the start of ...
(Date:7/24/2014)... July 24, 2014  Restore Health, a leading ... pharmaceuticals, announced that it is now offering pharmacogenetics ... each individual based upon their particular genetic makeup. ... the interaction between a patient,s genetics and their ... excited to provide this new service to healthcare ...
Breaking Medicine Technology:Parnell Acquires License for Intellectual Property and Rights to Develop Compounds for Bone and Dermal Regeneration 2Parnell Acquires License for Intellectual Property and Rights to Develop Compounds for Bone and Dermal Regeneration 3Parnell Acquires License for Intellectual Property and Rights to Develop Compounds for Bone and Dermal Regeneration 4Restore Health Launches Pharmacogenetic Testing, Enhancing Its Suite of Personalized Medicine Goods and Services 2Restore Health Launches Pharmacogenetic Testing, Enhancing Its Suite of Personalized Medicine Goods and Services 3
Cached News: