HOME >> MEDICINE >> NEWS
Stem cell transplantation procedure results in long-term survival for amyloidosis patients

(Boston) Researchers from the Stem Cell Transplant Program and the Amyloid Treatment and Research Program at Boston University Medical Center (BUMC) have found that high-dose chemotherapy and blood stem cell transplantation can result in long-term survival for patients diagnosed with primary systemic light chain (AL) Amyloidosis.

The findings appear prepublished in the First Edition of Blood and can be viewed on Blood Online at http://www.bloodjournal.org/papbyrecent.shtml. BUMC was the first to begin using this treatment in 1994 and is the only center to publish these long-term outcome results.

AL amyloidosis occurs when plasma cells in bone marrow produce proteins that misfold and deposit in tissues, leading to organ failure and death. Between 1,200 and 3,200 new cases are reported each year in the United States, although researchers believe the disease is highly underdiagnosed.

The researchers reviewed the records of 80 patients who received high-dose chemotherapy and blood stem cell transplantation from July 1994 through July 1997. The median survival for all 80 patients was 57 months. Eighteen of these patients, (23 percent) are still alive today, 10 or more years after undergoing the treatment. By comparison, only two percent of patients treated with oral melphalan and prednisone have survived more than 10 years.

According to lead researcher, Vaishali Sanchorawala, MD, an associate professor of medicine at Boston University School of Medicine, and clinical director of the Stem Cell Transplant Program, section of hematology/oncology at BUMC, high-dose intravenous melphalan and autologous stem cell transplantation has become a first-line treatment for patients with AL amyloidosis. However, efforts need to continue to be directed upon achieving a complete hematologic response in patients, she says. We are finding that the proportion of patients wh
'"/>

Contact: Gina DiGravio
gina.digravio@bmc.org
617-638-8491
Boston University
7-Aug-2007


Page: 1 2

Related medicine news :

1. UPMC begins study of heart support device as a bridge to transplantation
2. HCV patients survival after liver transplantation is not improving
3. Study suggests use of stem cell transplantation is beneficial treatment of type 1 diabetes
4. U of MN Center for Bioethics receives grant to study living donor lung transplantation
5. Edmonton Protocol clinical trial shows islet transplantation shows promising results
6. Clinical trial shows islet transplantation is a promising procedure
7. Landmark study of islet transplantation reveals potential benefits in uncontrolled type 1 diabetes
8. MRI can track survival of pancreatic islets after transplantation
9. Reconstructive surgeon aims for rejection-free limb transplantation
10. Fatigue a lasting problem after liver transplantation
11. ISHLT celebrates 20th anniversary of infant cardiac transplantation

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/1/2020)... , ... September 01, 2020 , ... ... has completed $3 million convertible note financing, which will be used to accelerate ... the funds from this financing, the company will continue to expand its customer ...
(Date:8/31/2020)... ... , ... Cardiothoracic surgeons at Allegheny General Hospital (AGH), part ... (CMU) to develop a new heart monitoring device designed to serve as an ... AGH/CMU team was recently awarded a “Trailblazer” grant from the National Institutes of ...
(Date:8/31/2020)... NEW YORK (PRWEB) , ... August 31, 2020 , ... ... On September 1, Cerebral Palsy Alliance Research Foundation (CPARF) is thrilled to launch its ... cerebral palsy research. A fully virtual challenge, STEPtember meets everyone wherever they are at ...
(Date:8/31/2020)... ... 31, 2020 , ... The pandemic and topsy-turvy economic outlook continues to put financial strain on ... ways to trim the fat from our monthly expenses and put more into savings, if ... that you have a financial safety net in place in case something were to happen ...
(Date:8/31/2020)... (PRWEB) , ... August 31, 2020 , ... ... intended to improve outcomes for patients with advanced heart failure, today announced that ... grant in the amount of $555,358 from the National Heart, Lung, and Blood ...
Breaking Medicine News(10 mins):
(Date:9/3/2020)... ... September 03, 2020 , ... ... Lab ( https://www.colorado.edu/lab/vance/masks ), an aerosol and engineering lab, conducted tests on Q&J’s ... against the COVID-19 virus than many other masks. Q&J face masks have both ...
(Date:9/2/2020)... ... , ... U.S. Dermatology Partners is excited to welcome Board-Certified Dermatologist ... Bethesda Dermatopathology Lab. , Jonathan Lee, MD grew up in the California ... went on to receive his M.D. with Honors from Harvard Medical School and pre-doctoral ...
(Date:9/1/2020)... ... September 01, 2020 , ... Breast and ovarian cancers are ... (CDC), About 3% of breast cancers (about 7,500 women per year) and 10% of ... and BRCA2 genes. Both genes are detectable in the Women’s Excellence Genetic Testing ...
Breaking Medicine Technology:
Cached News: