HOME >> MEDICINE >> NEWS
Stem cell transplants improve recovery in animal models for stroke, cerebral palsy

surements were made of their performance. Following the stroke, both control animals and those that received a single injection of stem cells were evaluated for a period of up to 2 months. Improvements in stem cell treated animals included enhanced performance across the range of tests, which examined strength, balance, agility and fine motor skills, and also included greater recovery of injured tissue.

"A single dose of the cells produce robust behavioral recovery at an early period post-transplantation and the recovery was durable, lasting up to two months, which was the entire length of this study," Dr. Borlongan said. "Furthermore, animals continued to show improvement over time." In the newborn model of ischemic injury, enhanced recovery was found within two weeks.

Even though less than 1 percent of the transplanted cells were present two months later, animals receiving treatment developed new neurons, apparently formed from endogenous stem cells. "The mechanism that we are putting forward is these donor cells are secreting nourishing trophic factors that are helping the host brain cells survive and stimulating stem cells from the host to multiply," Dr. Borlongan said.

To help mimic potential clinical scenarios for stroke victims, transplants were performed seven days after the intitial injury. Currently, ischemic stroke patients may be treated with tPA, the only FDA-approved stroke treatment available, but must receive treatment within three hours from the time the stroke initially occurs. As a result, 95-97 percent of ischemic stroke victims never receive treatment with tPA.

In the adult stroke model, MCG researchers found giving stem cells increased the number of injured cells that survived in the area just outside the area of greatest damage, also referred to as the ischemic core, by 5-20 percent.

"Up to this point, all the treatment approaches, including transplantation and tPA, cannot get rid of that ischemic
'"/>

Contact: Toni Baker
tbaker@mcg.edu
706-721-4421
Medical College of Georgia
7-Apr-2006


Page: 1 2 3 4 5

Related medicine news :

1. Thymus transplants gives hope to babies with fatal immune disease
2. Outcomes for patients with hepatitis B who need liver transplants
3. Women given liver transplants outlive male recipients by around 4 years
4. How tumors respond to treatment prior to liver transplants may be useful in selecting recipients
5. National trial gives unprecedented support for steroid withdrawal in kidney transplants
6. Organ transplants just as successful in those with mental retardation
7. Liver transplants can be successful in HIV patients with Hepatitis B
8. Despite medical advances, children receiving liver transplants wait longer than a decade ago
9. Predicting successful outcomes in living-donor liver transplants
10. Double transplants may offer one solution to short supply of donated kidneys
11. Neural transplants provide persistent benefit in patients with Huntingtons disease

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/31/2020)... ... August 31, 2020 , ... Ocean Springs, Mississippi-based pharmaceutical ... medical first responders across the United States. Since the start of the global ... (PPE) medical centers , hospitals , firefighters , and ...
(Date:8/31/2020)... N.J. (PRWEB) , ... August 31, 2020 , ... ... leading cloud-based business management solution for chiropractors, announced today the launch of its ... healthcare professionals can start running their virtual practice in under 90 seconds. ...
(Date:8/31/2020)... ... 2020 , ... Smile Brands Inc., one of the nation’s ... today announced the grand opening of another affiliated Bright Now! Dental office ... hours, a comfortable office, and full-service care at the new Beaumont location. The ...
(Date:8/31/2020)... ... , ... A Cure for Covid-19 “PTS” with Mediation & Hypnosis , At this very ... of panic, experiencing deep anxiety, immense stress, and right now are needing serious relief from ... people on the planet are experiencing a great degree of emotional discomfort, be it fear ...
(Date:8/31/2020)... ... August 31, 2020 , ... ... both directly with persons with autism and other developmental disabilities, as well as ... intervention, parent education, adolescents with autism, school consultation, and staff development. She joined ...
Breaking Medicine News(10 mins):
(Date:9/1/2020)... ... September 01, 2020 , ... September is National Ovarian ... for more deaths than any other cancer of the female reproductive system. The ... ovarian cancer and about 14,000 women will die from this disease. Throughout the ...
(Date:8/31/2020)... ... August 31, 2020 , ... Continuing on its ... broad-spectrum sanitization, disinfection and deodorization provider - is proud to announce it has ... services for businesses and residents throughout the area. , Germinator provides a 100% ...
(Date:8/28/2020)... LOS ANGELES (PRWEB) , ... August 28, 2020 , ... ... a board-certified reproductive and endoscopic surgeon and serves as a clinical professor in the ... elected President of the American Laparoscopy Society & Pacific Coast Reproductive Society and is ...
Breaking Medicine Technology:
Cached News: