Chicago Researchers found that prolonged use of anabolic androgenic steroid (AAS) is closely associated with significant levels of gingival enlargement, according to a new study published in the Journal of Periodontology.

Gingival overgrowth is a condition in which the gingival tissues become swollen and grow over the teeth. Overgrown gums make it easier for bacteria found in plaque to accumulate and attack supporting structures of the teeth, potentially leading to severe periodontal infection.

"It was found that AAS abusers had statistically significant levels of gingival enlargement compared to non-users, requiring a gingivectomy for many cases," explains Onur Ozcelik, DDS, PhD, Faculty of Dentistry, Cukurova University, Department of Periodontology, Adana, Turkey. "Although it has been reported that many of the adverse effects of AAS abuse are fully reversible within several months after the cessation of the drug, it is not known if gingival enlargement would also regress after the withdrawal of AAS."

Researcher also found that gingival inflammation was higher in the AAS user group compared to the non-AAS users. "Further studies are required to find out if increased gingival scores in the user group are a direct effect of AAS or if the inflammation is a result of compromised oral hygiene due to gingival enlargement," said Ozcelik.

"It is not surprising that gingival tissue is a target for the actions of steroid hormones," said Kenneth A. Krebs, DMD and AAP president. "Clinical changes in tissues of the periodontium have been identified during periods of hormonal fluctuations such as puberty, the menstrual cycle, pregnancy, menopause, contraceptives and ovulation induction drugs in women."

People taking AAS without medical supervision should be informed of the adverse effects and strongly encouraged to begin a cessation program.

Since periodontal infection may be a risk factor for more serious
'"/>

Contact: Kerry Gutshall
kerry@perio.org
312-573-3243
American Academy of Periodontology
5-Jul-2006