HOME >> MEDICINE >> NEWS
Stress significantly hastens progression of Alzheimer's disease

Irvine, Calif.,August 29, 2006-- Stress hormones appear to rapidly exacerbate the formation of brain lesions that are the hallmarks of Alzheimer's disease, according to researchers at UC Irvine. The findings suggest that managing stress and reducing certain medications prescribed for the elderly could slow down the progression of this devastating disease.

In a study with genetically modified mice, Frank LaFerla, professor of neurobiology and behavior, and a team of UCI researchers found that when young animals were injected for just seven days with dexamethasone, a glucocorticoid similar to the body's stress hormones, the levels of the protein beta-amyloid in the brain increased by 60 percent. When beta-amyloid production increases and these protein fragments aggregate, they form plaques, one of the two hallmark brain lesions of Alzheimer's disease. The scientists also found that the levels of another protein, tau, also increased. Tau accumulation eventually leads to the formation of tangles, the other signature lesion of Alzheimer's. The findings appear in this week's issue of the Journal of Neuroscience.

"It is remarkable that these stress hormones can have such a significant effect in such a short period of time," LaFerla said. "Although we have known for some time that higher levels of stress hormones are seen in individuals in the early stages of Alzheimer's, this is the first time we have seen how these hormones play such a direct role in exacerbating the underlying pathology of the disease."

The researchers injected four-month-old transgenic mice with levels of dexamethasone similar to the level of hormones that would be seen in humans under stress. At this young age, there would be little formation of plaques and tangles in the brains of the mice. After one week, the scientists found that the level of beta-amyloid in the brains of the animals compared to what is seen in the brains of untreated eight- to nine-month-old mice, demo
'"/>

Contact: Farnaz Khadem
fkhadem@uci.edu
949-824-5484
University of California - Irvine
29-Aug-2006


Page: 1 2 3

Related medicine news :

1. Stress may leave your mouth a mess
2. Stress of deployment increases risk of child abuse, neglect in military families, UNC study shows
3. Stress, childhood trauma linked to chronic fatigue syndrome in adults
4. Stress triggers relapse in meth abuse, OHSU study finds
5. Stress, alcoholics, and post-traumatic stress disorder
6. Stressed-out women more likely to miscarry early
7. Stress and emotions can negatively effect heart health
8. Stressed-out moms think their children are more difficult
9. Stress substantially slows human bodys ability to heal
10. Stress echo tests shown to predict cardiac death, illness in higher-risk women
11. Stress may increase long-term success of vaccinations

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/1/2018)... , ... August 31, 2018 , ... SignatureCare Emergency Center ... awarded for the Fall semester to a deserving student. Get your applications in now ... scholarship was awarded to Hanna Wu who is a medical student at Texas Southern ...
(Date:9/1/2018)... Texas (PRWEB) , ... September 01, 2018 , ... ... event proclaimed by the International Veterinary Academy of Pain Management (IVAPM) that aims ... Veterinary Medical Association (TVMA) is partnering with IVAPM by educating pet owners of ...
(Date:8/31/2018)... ... August 31, 2018 , ... MedMark Treatment Centers Kentwood, ... September 12 from 1:00-3:00 pm. MedMark invites the community to explore ... the facility, meet our staff and learn more about medication-assisted treatment services. MedMark ...
(Date:8/31/2018)... ... August 31, 2018 , ... The social impact documentary feature film ... Professor and NIH-funded researcher Luciana Lagana, aka Dr. Luciana, has been faring ... on Film International Film Festival, IndieFEST Film Awards, Shawna Shea Memorial Film Festival, and ...
(Date:8/31/2018)... ... 2018 , ... Nitro Circus hosted the inaugural A Night to Live Like ... gathering to celebrate the life of Erik Roner, world-renowned skier, skydiver and a founding ... and their two small children, Oskar (8) and Kasper (4). A portion of the ...
Breaking Medicine News(10 mins):
(Date:9/13/2018)... ... September 13, 2018 , ... This September is Centers for Disease ... to raise awareness on how to help prevent food poisoning. According to the CDC, ... 128,000 are hospitalized, and 3,000 die from eating contaminated food. In support of the ...
(Date:9/13/2018)... ... September 13, 2018 , ... ... | 2018" list. , Hospitals and health systems rely on CIOs and IT ... as support telehealth, data-gathering and cybersecurity initiatives. Those who lead community hospital and ...
(Date:9/12/2018)... , ... September 13, 2018 , ... Donaldson Plastic Surgery ... as well as Columbus Business First's Fast 50 list of central Ohio's fastest growing ... a 3-year growth rate of 81 percent. It is the only medical practice and ...
Breaking Medicine Technology:
Cached News: