HOME >> MEDICINE >> NEWS
Studies examine menopausal hormone therapy and risk of breast cancer recurrence

The doses of estrogen and progestogen used in menopausal hormone therapy may be related to the risk of breast cancer recurrence, according to a new study in the April 6 issue of the Journal of the National Cancer Institute.

In 1997, two randomized trials, the Hormonal Replacement Therapy--Is It Safe? (HABITS) trial and the Stockholm trial, began in Sweden to test the effects of menopausal hormone therapy in women after they had been diagnosed with early-stage breast cancer. The HABITS trial, which ultimately included 434 breast cancer patients, was halted early in December 2003 because, at a median follow-up of only 2.1 years, the risk of breast cancer recurrence among women receiving hormone therapy was 3.3 times higher than the risk among women receiving no treatment.

Eva von Schoultz, M.D., Ph.D., and Lars E. Rutqvist, M.D., Ph.D., of the Karolinska Institute, in Stockholm, Sweden, and the Stockholm Breast Cancer Study Group now report the results of the Stockholm trial, in which 378 breast cancer patients were randomly assigned to receive either menopausal hormone therapy for 5 years or no treatment. The trial was similar to the HABITS trial but used a hormone therapy regimen that differed in composition and timing.

In the Stockholm trial, after a median of 4.1 years of follow-up, there was no association between hormone therapy use and the risk of breast cancer recurrence. The authors suggest that differences in the composition and timing of the hormone therapy used in the Stockholm trial could explain why the trial's results differed from those of the HABITS trial.

"Although it is tempting to speculate that treatment regimens with estrogen and a minimum of progestogen may be safe, the management of menopausal symptoms and quality of life for patients with breast cancer remains an important unsolved problem," the authors write. "Because doses of estrogen and progestogen and treatment regimens may be associated with the rec
'"/>

Contact: Sarah L. Zielinski
jncimedia@oupjournals.org
301-841-1287
Journal of the National Cancer Institute
5-Apr-2005


Page: 1 2

Related medicine news :

1. Studies show antidepressants not linked to birth defects
2. Studies show role of age, gender, race and weight on cancer risk and treatment
3. Studies suggest investigational agent reduces disease activity in MS
4. Studies highlight advances in diagnosis, medical therapy
5. Studies highlight real world use, safety of drug-eluting stents
6. Studies led by Rhode Island Hospital confirm safety and efficacy
7. Studies identify food sources of disease and drug resistance
8. Studies provide new evidence on risks associated with Cox-2 inhibitors and NSAIDs
9. Studies highlight need to monitor heart function in breast cancer patients
10. Studies examine physician disclosure of medical errors
11. Studies indicate medication can be an effective therapy for smoking cessation

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... ... October 13, 2017 , ... Southern ... and Jennifer Huggins, PharmD ’17, along with clinical associate professor Janice Frueh, ... cardiovascular diseases during the 15th Annual Women’s Health Conference. The SIU School ...
(Date:10/13/2017)... SAN LUIS OBISPO, Calif. (PRWEB) , ... October 13, 2017 , ... ... with Alzheimer’s or dementia. However, many long-term care insurance companies have a waiver for ... mean is the 90-day elimination period, when the family pays for care, is often ...
(Date:10/13/2017)... ... October 13, 2017 , ... Global Healthcare Management’s 4th Annual ... in Milford, NJ. This free event, sponsored by Global Healthcare Management’s CEO, Jon ... fun run is geared towards children of all ages; it is a non-competitive, non-timed ...
(Date:10/13/2017)... VA (PRWEB) , ... October 13, 2017 , ... ... of DevOps and Agile Software Development, has been awarded a contract by the ... Blanket Purchase Agreement (BPA) aims to accelerate the enterprise use of Agile methodologies ...
(Date:10/12/2017)... ... October 12, 2017 , ... First ... compliance program management, will showcase a range of technology and learning solutions at ... (NCAL) Convention and Expo to be held October 14–18, 2017 at the Mandalay ...
Breaking Medicine News(10 mins):
(Date:9/25/2017)... R.I. , Sept. 25, 2017  EpiVax, ... assessment, vaccine design, and immune-engineering today announced the ... on the development of personalized therapeutic cancer vaccines. ... has provided exclusive access to enabling technologies to ... Eng., MBA will lead EpiVax Oncology as Chief ...
(Date:9/19/2017)... Mich. , Sept. 19, 2017 HistoSonics, Inc., a venture-backed medical device company ... destruction of targeted tissues, announced three leadership team developments today:   ... PhD ... ... Veteran medical device executive Josh ...
(Date:9/13/2017)... ATLANTA , Sept. 13, 2017   OrthoAtlanta ... to the Atlanta Football Host Committee (AFHC) for the 2018 ... Monday, Jan. 8, 2018, at Mercedes-Benz Stadium in ... part of the AFHC "I,m In" campaign, participating in many ... ...
Breaking Medicine Technology:
Cached News: