Studies highlight global risks of vascular disease, probe creative new treatments

vitamin B6, and vitamin B12 are involved in several steps of the complex homocysteine metabolic pathway, ultimately enhancing homocysteine breakdown and excretion.

The HOPE-2 trial involved an international team of researchers from 145 medical centers in 13 countries in North America, South America, and Europe. Investigators enrolled 5,522 patients with established cardiovascular disease or diabetes, randomly assigning them to daily vitamin intake with folic acid, 2.5 mg; vitamin B6, 50 mg; and vitamin B12, 1 mg, or placebo. After two years of vitamin supplements, homocysteine levels were reduced by about 25 percent.

Dr. Lonn will report on the clinical results of a follow-up averaging five years at a Late Breaking Clinical Trial session on Monday, March 13, at 2 p.m.

One-Year Cardiovascular Event Rates in a Global Contemporary Registry of Over 68,000 Outpatients with Atherothrombosis: The Reduction of Atherothrombosis for Continued Health (REACH) Registry Results

Patients with atherothrombosis--a condition in which atherosclerosis is complicated by a propensity to form blood clots-- have a surprisingly high risk of death or major cardiovascular illness, even in stable form, according to data from a large international registry. Within a year, one in eight patients will die, will have a heart attack or stroke, or will be hospitalized for a complication of clogged arteries. The risk is even greater for patients with widespread vascular disease.

"I find these event rates to be high, given that we are dealing with a stable outpatient population treated with contemporary therapy," said Philippe Gabriel Steg, M.D., a professor of cardiology at Universit Paris-7 and director of the coronary care unit at Hpital Bichat-Claude Bernard, Assistance Publique-Hpitaux de Paris, France.

This study was specifically designed to determine the "real-world" risk of a major adverse cardiovascular event (MACE) in patients with eith


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