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Studies highlight global risks of vascular disease, probe creative new treatments

er established atherothrombotic disease or a high risk for the condition. Drawing from a wide geographic area--44 countries in all--Dr. Steg and his colleagues recruited 68,000 patients with a history of coronary artery disease (CAD), cerebrovascular disease (CVD), or peripheral vascular disease (PVD), or at least three risk factors for atherothrombosis, including diabetes, uncontrolled high blood pressure, uncontrolled high blood cholesterol levels, cigarette smoking and advanced age. Participants were enrolled in the Reduction of Atherothrombosis for Continued Health (REACH) registry and will be followed-up for four years.

At one-year follow-up, investigators observed an overall MACE rate of 13 percent. However, patients with peripheral arterial disease--clogged arteries in the legs or abdominal organs--were at substantially higher risk, experiencing a one-year MACE rate of 22 percent. In addition, there was a stepwise increase in risk in those with widespread vascular disease. In patients with atherothrombotic disease in one location only, the MACE rate was 13 percent, whereas in those with atherothrombotic disease in three locations, the MACE risk climbed to 28 percent.

"It is critical that we stop viewing atherothrombosis as a cardiac, neurologic, or vascular disease and, instead, view it as a global disease," Dr. Steg said.

Dr. Steg will present the full one-year REACH registry results at a Late Breaking Clinical Trials session on Sunday, March 12, at 10:52 p.m.

Safety and Efficacy of Bone Marrow Mobilization With Granulocyte-macrophage Colony Stimulating Factor in Patients With Intermittent Claudication

A build-up of atherosclerotic plaque in the arteries of the legs can restrict blood flow and even make walking painful, a condition known as intermittent claudication. If the disease is widespread, it may be impossible to treat with conventional approaches, such as angioplasty or vascular surgery. Researc
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12-Mar-2006


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