Studies highlight need to monitor heart function in breast cancer patients

Alexandria, VA--Two new studies support the need to monitor heart function among breast cancer patients receiving two common therapies. The findings are particularly important for women who have other risk factors for heart disease or cardiac dysfunction before treatment begins. The studies will be published online August 14 in the Journal of Clinical Oncology (JCO).

In the first study, researchers at M.D. Anderson Cancer Center in Houston found that 28% of women with advanced breast cancer who received trastuzumab (Herceptin) for a year or more experienced impaired heart function that could be reversed with medical treatment. Among 218 patients with metastatic breast cancer who received long-term trastuzumab between 1998 and 2003 and were followed for nearly three years, 15.6% had a moderate reduction in left ventricular ejection fraction (LVEF, a measure of the heart's pumping ability) that did not cause any symptoms, and 10.9% developed impaired heart function that caused symptoms such as shortness of breath and fluid retention. One patient died of congestive heart failure. Women whose LVEF was lower than normal before therapy began were more likely to experience an impairment of heart function as a result of treatment.

"Long-term use of Herceptin appears to be safe, but some patients will experience cardiac toxicity. The good news is that this toxicity appears to be reversible with medical treatment such as beta-blockers and ACE inhibitors," explained Francisco Esteva, MD, Associate Professor of Medicine at M.D. Anderson and the study's senior author.

In an accompanying editorial, Daniel Hayes, MD, of the University of Michigan Comprehensive Cancer Center, and Michael H. Picard, MD, of Massachusetts General Hospital, wrote, "Careful and frequent monitoring of patients treated with trastuzumab should include a history and physical examination in addition to non-invasive imaging of ventricular function."



Contact: Danielle Potuto
American Society of Clinical Oncology

Page: 1 2 3

Related medicine news :

1. Studies show antidepressants not linked to birth defects
2. Studies show role of age, gender, race and weight on cancer risk and treatment
3. Studies suggest investigational agent reduces disease activity in MS
4. Studies highlight advances in diagnosis, medical therapy
5. Studies highlight real world use, safety of drug-eluting stents
6. Studies led by Rhode Island Hospital confirm safety and efficacy
7. Studies identify food sources of disease and drug resistance
8. Studies provide new evidence on risks associated with Cox-2 inhibitors and NSAIDs
9. Studies examine physician disclosure of medical errors
10. Studies indicate medication can be an effective therapy for smoking cessation
11. Studies evaluating health effects of dental amalgam fillings in children confirm safety

Post Your Comments:

(Date:2/19/2020)... ... February 19, 2020 , ... SafiraMD Medical Aesthetics ... FDA-cleared CoolSculpting®, the world’s most popular non-invasive fat reduction treatment. Their CoolEvent will ... Halcyon Village Center in Alpharetta, Georgia. The CoolEvent will feature live demonstrations, exclusive ...
(Date:2/15/2020)... ... February 14, 2020 , ... UMF Corporation ... Easley Hospital , a member of Prisma Health, providing a comprehensive PCPLUS ... hospital was able to cut its monthly laundry management costs in half, support ...
(Date:2/14/2020)... ... 2020 , ... ScripHessco has announced the release of their ... down the benefits of chiropractic care during pregnancy and how to find a ... beneficial to the mother’s health. Seeing a chiropractor during pregnancy leads to a ...
(Date:2/14/2020)... Pa. (PRWEB) , ... February 14, 2020 , ... ... consumers were most bothered by excess weight, skin texture and discoloration, and lines ... skin tightening and injectables. MilfordMD is offering some great specials in February specifically ...
(Date:2/13/2020)... ... February 13, 2020 , ... The largest fertility center ... Fair Oaks, Fairfax, Fredericksburg, Leesburg, and Woodbridge, as well as two locations in ... have been named as Top Docs for Infertility by Northern Virginia Magazine. ...
Breaking Medicine News(10 mins):
(Date:2/20/2020)... ... February 20, 2020 , ... ... needs in the field of urology, today announced that Jayant Uberoi, MD, Chesapeake ... The designation recognizes that Dr. Uberoi has achieved a high level of training ...
(Date:2/19/2020)... ... 2020 , ... Today, Georgetown Home Care (GHC) ... the lowest in the company’s history. , Georgetown Home Care’s hospital readmission ... GHC’s skilled nursing facility (SNF) rehospitalization rate was 0 percent in 2019. When ...
(Date:2/19/2020)... ... February 19, 2020 , ... The ... best colleges and universities for people with disabilities. , The Edvocate highlighted ... with disabilities succeed in higher education. AIC placed in the top ten with ...
Breaking Medicine Technology:
Cached News: