Studies highlight need to monitor heart function in breast cancer patients

Alexandria, VA--Two new studies support the need to monitor heart function among breast cancer patients receiving two common therapies. The findings are particularly important for women who have other risk factors for heart disease or cardiac dysfunction before treatment begins. The studies will be published online August 14 in the Journal of Clinical Oncology (JCO).

In the first study, researchers at M.D. Anderson Cancer Center in Houston found that 28% of women with advanced breast cancer who received trastuzumab (Herceptin) for a year or more experienced impaired heart function that could be reversed with medical treatment. Among 218 patients with metastatic breast cancer who received long-term trastuzumab between 1998 and 2003 and were followed for nearly three years, 15.6% had a moderate reduction in left ventricular ejection fraction (LVEF, a measure of the heart's pumping ability) that did not cause any symptoms, and 10.9% developed impaired heart function that caused symptoms such as shortness of breath and fluid retention. One patient died of congestive heart failure. Women whose LVEF was lower than normal before therapy began were more likely to experience an impairment of heart function as a result of treatment.

"Long-term use of Herceptin appears to be safe, but some patients will experience cardiac toxicity. The good news is that this toxicity appears to be reversible with medical treatment such as beta-blockers and ACE inhibitors," explained Francisco Esteva, MD, Associate Professor of Medicine at M.D. Anderson and the study's senior author.

In an accompanying editorial, Daniel Hayes, MD, of the University of Michigan Comprehensive Cancer Center, and Michael H. Picard, MD, of Massachusetts General Hospital, wrote, "Careful and frequent monitoring of patients treated with trastuzumab should include a history and physical examination in addition to non-invasive imaging of ventricular function."



Contact: Danielle Potuto
American Society of Clinical Oncology

Page: 1 2 3

Related medicine news :

1. Studies show antidepressants not linked to birth defects
2. Studies show role of age, gender, race and weight on cancer risk and treatment
3. Studies suggest investigational agent reduces disease activity in MS
4. Studies highlight advances in diagnosis, medical therapy
5. Studies highlight real world use, safety of drug-eluting stents
6. Studies led by Rhode Island Hospital confirm safety and efficacy
7. Studies identify food sources of disease and drug resistance
8. Studies provide new evidence on risks associated with Cox-2 inhibitors and NSAIDs
9. Studies examine physician disclosure of medical errors
10. Studies indicate medication can be an effective therapy for smoking cessation
11. Studies evaluating health effects of dental amalgam fillings in children confirm safety

Post Your Comments:

(Date:8/31/2020)... (PRWEB) , ... August 31, 2020 , ... The pandemic and topsy-turvy economic outlook continues ... our budgets and look for ways to trim the fat from our monthly expenses and ... finances, but it’s also important that you have a financial safety net in place in ...
(Date:8/31/2020)... ... 31, 2020 , ... Bonde Innovations, LLC, a venture-backed developer ... failure, today announced that the company has been awarded a Phase 1 Small ... Heart, Lung, and Blood Institute of the National Institutes of Health (NIH). The ...
(Date:8/28/2020)... ... August 28, 2020 , ... The 15 scholarships being ... Health & Wellness mobile app and web-portal. NCPCV received a 2020 grant from ... grants each year to organizations, such as Destination Imagination, which support and advance ...
(Date:8/28/2020)... ... August 28, 2020 , ... ... that strongly suggest that obese individuals are at an increased risk of developing ... more likely to catch COVID-19; however, because the same organ systems that the ...
(Date:8/26/2020)... ... 26, 2020 , ... Smile Brands Inc. CEO, Steven C. ... leading a session entitled, “A CEO Guide for Delivering and Measuring Inclusion Success”. ... bring together the world’s leading diversity and inclusion executives, HR consultants, and D&I ...
Breaking Medicine News(10 mins):
(Date:8/27/2020)... Calif. (PRWEB) , ... August 27, 2020 , ... ... the conclusion of its fundraising initiative for Feeding San Diego with a ... What: The GHT Companies presents the final check of $5,000.00+ representing an overall donation ...
(Date:8/26/2020)... DIEGO (PRWEB) , ... August 26, 2020 , ... AseptiScope, ... 2020 Infection Control Company of the Year by MedTech Outlook. , “AseptiScope ... Officer. “For the first time, clinicians who wear gloves on their hands, goggles on ...
(Date:8/26/2020)... , ... August 26, 2020 , ... ... in-home air purification systems kill Coronavirus. While air purification technologies, including GreenTech Environmental’s ... SARS and even Ebola, no air purification system has published results of singular ...
Breaking Medicine Technology:
Cached News: