HOME >> MEDICINE >> NEWS
Studies indicate medication can be an effective therapy for smoking cessation

The drug varenicline shows effectiveness in helping smokers quit and abstain from smoking when compared to placebo and the smoking cessation medication bupropion, according to three studies in the July 5 issue of JAMA.

Although nearly 41 percent of smokers try to quit smoking each year, relapse is common, and only about 10 percent achieve and maintain abstinence. The negative effects of nicotine withdrawal account, in part, for low success rates, according to background information in the article. Approved pharmacotherapies to treat nicotine dependence (e.g., nicotine replacement therapy and bupropion) have had important, but moderate efficacy, with reported rates of quitting generally twice those of placebo. Additional and more effective therapies are needed.

David Gonzales, Ph.D., of Oregon Health & Science University, Portland, and colleagues with the Varenicline Phase 3 Study Group evaluated the efficacy of varenicline compared with placebo and sustained-release (SR) bupropion in generally healthy adult smokers. Varenicline is a non-nicotine drug that is thought to be beneficial for smoking cessation by stimulating the release of the chemical dopamine in the brain to reduce craving and withdrawal while simultaneously blocking the reinforcing effects of smoked nicotine. Most other smoking cessation pharmacotherapies are nicotine replacement products.

Participants in the study were 1,025 smokers (10 cigarettes or more per day) with fewer than 3 months of smoking abstinence in the past year. The randomized, double-blind, phase 3 clinical trial was conducted at 19 U.S. centers from June 2003 to April 2005. Participants were randomly assigned to receive brief counseling plus either varenicline twice per day (n = 352), bupropion SR twice per day (n = 329), or placebo (n = 344) orally for 12 weeks, with 40 weeks of nondrug follow-up.

The carbon monoxideconfirmed 4-week continuous abstinence rate for weeks 9 th
'"/>

Contact: Tamara Hargens
503-494-8231
JAMA and Archives Journals
4-Jul-2006


Page: 1 2 3 4 5 6 7

Related medicine news :

1. Studies show antidepressants not linked to birth defects
2. Studies show role of age, gender, race and weight on cancer risk and treatment
3. Studies suggest investigational agent reduces disease activity in MS
4. Studies highlight advances in diagnosis, medical therapy
5. Studies highlight real world use, safety of drug-eluting stents
6. Studies led by Rhode Island Hospital confirm safety and efficacy
7. Studies identify food sources of disease and drug resistance
8. Studies provide new evidence on risks associated with Cox-2 inhibitors and NSAIDs
9. Studies highlight need to monitor heart function in breast cancer patients
10. Studies examine physician disclosure of medical errors
11. Studies evaluating health effects of dental amalgam fillings in children confirm safety

Post Your Comments:
(Date:9/4/2015)... ... 04, 2015 , ... Friday night, Chicago lovebirds Jenny McCarthy and Donnie Wahlberg ... Hope event supporting families affected by autism, raising nearly $250,000. , 150 guests, ... at the Oscar Swan Inn to support the cause. , McCarthy tugged the ...
(Date:9/3/2015)... ... 03, 2015 , ... TransPack Toon gives users a set of 90 cartoon ... framing transitions in 30 different styles. Presets range from snow, underwater, forest, futuristic, city ... TransPack Toon features 90 cartoon transitions from 30 unique styles. Editors can choose ...
(Date:9/3/2015)... ... September 03, 2015 , ... E-Volve ... a leading national healthcare solutions organization, to provide electronic medical record (EMR) consulting ... agreement, Amerinet members will receive negotiated pricing on E-Volve Health’s Epic EMR consulting, ...
(Date:9/3/2015)... ... September 03, 2015 , ... DriButts, a non-profit organization dedicated ... Product Development Group to manufacture a long-lasting reusable diaper for warm weather climates ... to bring 600 DriButts Diapers to rural areas of Haiti during a trip ...
(Date:9/3/2015)... ... September 03, 2015 , ... ... to be situated at 4400 Columbine Drive in Bellingham, Washington. Silverado Bellingham, a ... has been carefully designed to serve up to 80 people living with Alzheimer’s, ...
Breaking Medicine News(10 mins):Health News:Jenny McCarthy & Donnie Wahlberg Help Raise Over $200,000 For Generation Rescue’s ‘Night Of Hope’ Chicago Charity Event 2Health News:Pixel Film Studios Releases TransPack Toon, a New FCPX Transition 2Health News:E-Volve Health to Offer EMR Consulting Solutions to Amerinet Members 2Health News:DriButts Diapers Rely on Slingshot Help in Haiti 2Health News:DriButts Diapers Rely on Slingshot Help in Haiti 3Health News:Site Dedication Ceremony to Celebrate New Silverado Memory Care Community 2
(Date:9/3/2015)... Sept. 3, 2015 Report ... New Drugs, Industry Changes and Emerging Opportunities What,s ... ovaries? Visiongain,s new study forecasts those pharmaceutical revenues. ... that industry. You also explore trends, results, treatments, ... report gives revenue predictions to 2025 at overall ...
(Date:9/3/2015)... About self-monitoring blood glucose device ... device. It consists of a glucose sensor and ... through radiowaves from the sensor to a receiver, ... self-monitoring blood glucose devices can improve self-management of ... diabetes treatment. Technavio,s analysts forecast the ...
(Date:9/3/2015)... Nevro Corp. (NYSE: NVRO ), a ... solutions for the treatment of chronic pain, today announced ... Stanley Global Healthcare Conference on Thursday, September 17, 2015 ... is scheduled to present at 11:45 a.m. ET.  The ... accessible in the "Investors" section of the company,s website ...
Breaking Medicine Technology:Ovarian Cancer Drug Therapy: Companies, R&D and Revenue Forecasts 2015-2025: Recently Approved Treatments Give High Market Potential 2Ovarian Cancer Drug Therapy: Companies, R&D and Revenue Forecasts 2015-2025: Recently Approved Treatments Give High Market Potential 3Ovarian Cancer Drug Therapy: Companies, R&D and Revenue Forecasts 2015-2025: Recently Approved Treatments Give High Market Potential 4Ovarian Cancer Drug Therapy: Companies, R&D and Revenue Forecasts 2015-2025: Recently Approved Treatments Give High Market Potential 5Ovarian Cancer Drug Therapy: Companies, R&D and Revenue Forecasts 2015-2025: Recently Approved Treatments Give High Market Potential 6Global Self-monitoring Blood Glucose Devices Market 2015-2019 2
Cached News: