Women treated for breast cancer who are considering taking Hormone Replacement Therapy (HRT) should be cautious when using published research to inform their decision. An article published today in the journal Breast Cancer Research reveals that qualitative studies on the recurrence of breast cancer in breast cancer survivors undergoing HRT are unreliable.

There are two main types of research studies qualitative and quantitative. Each type is used to answer different research questions. Dr Col, from Brown Medical School, USA, and colleagues found that all of the qualitative studies on the recurrence of breast cancer in patients taking HRT they looked at have "serious design features that could introduce selection, reporting and/or publication biases".

These qualitative studies have concluded that there is no increased risk of the recurrence of breast cancer in patients taking HRT, but the authors of today's study feel that this is not a reliable conclusion. Meanwhile, evidence from randomized controlled trials - a type of quantitative study suggests the opposite that there is an increased risk of the recurrence of breast cancer in patients taking HRT.

Patients and doctors, the authors conclude, should base their decision on randomised controlled trials, as these "provide the only reliable estimates of recurrence risk".

The authors scrutinized 10 studies on the recurrence of breast cancer in a total of 1,316 breast cancer survivors who used HRT and 2,839 who didn't. Out of the ten studies, the eight qualitative studies were positive and suggested that HRT decreases the risk of breast cancer recurrence by 0.64. The two randomised controlled trials found the opposite and concluded that HRT increases the risk of recurrence by 3.41.

The positive studies were all said to have methodological limitations that could not be controlled using statistical methods. For example, they selected healthier women to take HRT and followed t
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Contact: Juliette Savin
juliette@biomedcentral.com
44-207-631-9931
BioMed Central
18-May-2005

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