The Latest Biology News And Medical NewsBiology News 2Health News 2Biology News 3Health News 3
HOME >> MEDICINE >> NEWS
Studies provide new evidence on risks associated with Cox-2 inhibitors and NSAIDs

Two new review studies evaluating the safety of the pain-relieving medications selective cyclooxygenase 2 (COX-2) inhibitors and non-steroidal anti-inflammatory drugs (NSAIDs) find increased cardiovascular and kidney risks. The studies and an accompanying editorial were posted online today by JAMA because of the public health implications of the findings. The articles will appear in the October 4 print issue of JAMA.

"It is estimated that more than 30 million people worldwide take nonsteroidal anti-inflammatory drugs (NSAIDs) daily for treatment of pain and inflammation," according to background information provided in one of the articles. Adverse effects of some conventional NSAIDs include toxic gastrointestinal (GI) effects, as well as adverse renal (kidney) effects. "Overall, an estimated 2.5 million individuals in the United States annually experience adverse renal effects caused by use of NSAIDs," the authors write. "With decreased risk of adverse GI effects, a class of drugs that selectively inhibits COX-2 enzyme was introduced for analgesia (pain relief) and the treatment of arthritis." According to the authors, the adverse renal effects of selective COX-2 inhibition are unclear. Evidence is accumulating on the potential class effect of COX-2 inhibitors on cardiovascular risk. Two COX-2 inhibitors have already been withdrawn from the market: rofecoxib (marketed as Vioxx) and valdecoxib (marketed as Bextra).

Jingjing Zhang, M.D., Ph.D., from Brigham and Women's Hospital and Harvard Medical School, Boston, and colleagues evaluated the adverse risks of renal events and arrhythmia (disturbance of the normal heart rhythm) events in patients prescribed COX-2 inhibitors from a systematic review of the medical literature to determine if these negative side-effects involve every drug in this class.

"In this comprehensive meta-analysis of 114 randomized trials of COX-2 inhibitors comprised of 116,094 participants, rofecoxi
'"/>

Contact: Todd Datz
617-432-3952
JAMA and Archives Journals
12-Sep-2006


Page: 1 2 3 4 5

Related medicine news :

1. Studies show antidepressants not linked to birth defects
2. Studies show role of age, gender, race and weight on cancer risk and treatment
3. Studies suggest investigational agent reduces disease activity in MS
4. Studies highlight advances in diagnosis, medical therapy
5. Studies highlight real world use, safety of drug-eluting stents
6. Studies led by Rhode Island Hospital confirm safety and efficacy
7. Studies identify food sources of disease and drug resistance
8. Studies highlight need to monitor heart function in breast cancer patients
9. Studies examine physician disclosure of medical errors
10. Studies indicate medication can be an effective therapy for smoking cessation
11. Studies evaluating health effects of dental amalgam fillings in children confirm safety

Post Your Comments:
(Date:11/24/2009)...ustBeMadetoUSPSTFRepresentationandRecommendationPr...re/-- SeveralsectionsofSenatehealthcarereformlegis...tiessuchasprivateinsurers,MedicareandMedicaidwould...defromtheU.S.PreventativeServicesTaskForce.Present...9,wouldonlyrequirecoverageofbiennial(everyotheryea...
(Date:11/24/2009)...AEL November 24, 2009 Researchers at Ben-Gurion U... that detects cancerous skin tumors, including mel...uring initial testing, the OSPI instrument (Optica...res of lesions that have never been seen before - ...with various skin lesions and were awaiting surger...
(Date:11/24/2009)...nvolving family members of pediatric cancer and he...the family and the medical team, according to a ne... Riley Hospital for Children, where the study was...ospitals nationwide routinely offering the parents...pportunity to join their child,s medical team as a...
(Date:11/24/2009)...will hold its Conjoint Mid-Winter Meetings Jan. 27... in Albuquerque, N.M. This year, SNM joins its ann... Annual Meeting and Educational Symposium of the A...nomedicine and Molecular Imaging Summit and the Cl...n-day event offers participants an outstanding ran...
(Date:11/24/2009)...fluent families are at higher risk, study finds ,...lthough children from poorer families who have chi...l injuries, child care could actually protect kids..., In the report, published online Nov. 24 in the ...searchers looked at a study of 14,000 children in ...
Breaking Medicine News(10 mins):Health News:USPSTF Mammography Recommendations Should Be Specifically Excluded From Health Care Reform Legislation 2Health News:USPSTF Mammography Recommendations Should Be Specifically Excluded From Health Care Reform Legislation 3Health News:New device enables early detection of cancerous skin tumors -- Ben Gurion U. 2Health News:Involving family in medical rounds benefits both family and medical team 2Health News:Involving family in medical rounds benefits both family and medical team 3Health News:Involving family in medical rounds benefits both family and medical team 4Health News:SNM's Conjoint Mid-Winter Meetings offer 4 scientific meetings in 1 location 2
(Date:11/23/2009)..., WASHINGTON,Nov.23/PRNewswire-USNewswire/--Febe...nNov.20,2009,toparticipatinginaschemetodefraudtheE...than$1million,announcedAssistantAttorneyGeneraloft...eneralOsvaldoL.GratacosoftheEx-ImBank,OfficeoftheI...udgeRichardW.RobertsinU.S.DistrictCourtinWashingto...
(Date:11/23/2009)..., NATICK,Mass.,Nov.23/PRNewswire-FirstCall/--Bos...articipateinthePiperJaffrayHealthCareConference,De...tiveOfficerandSamLeno,ExecutiveVicePresidentandChi...ussionabouttheCompanyonTuesday,December1st,beginni...thisdiscussionwillbeavailabletoallinterestedpartie...
(Date:11/23/2009)..., CUPERTINO,Calif.,Nov.23/PRNewswire-FirstCall/-...tMattHogan,ChiefFinancialOfficer,andJoeStauffer,Ch...iperJaffrayHealthCareConferenceonTuesday,December1...ewYorkPalaceHotelinNewYorkCity. ,, (Logo: http:... ,, Toaccessthelivepresentationviatheinternet,p...
Breaking Medicine Technology:Colombian National Pleads Guilty to Role in Defrauding the Export-Import Bank of the United States of More Than $1 Million 2DURECT to Present at the 21st Annual Piper Jaffray Health Care Conference 2Pump Up The Volume 3A Equinox Releases Exclusive Celebrity Playlists 55785 1Pump Up The Volume 3A Equinox Releases Exclusive Celebrity Playlists 55785 2TDI Announces New Reseller Agreement With Executone 55781 1TDI Announces New Reseller Agreement With Executone 55781 2In Final Hour Prior to Litigation Angel MedFlights Air Ambulance Team Overturns Decision by Major Insurance Company 55776 1In Final Hour Prior to Litigation Angel MedFlights Air Ambulance Team Overturns Decision by Major Insurance Company 55776 2In Final Hour Prior to Litigation Angel MedFlights Air Ambulance Team Overturns Decision by Major Insurance Company 55776 3
Other News:
...c. 6, 2005, Issue......1. Heart Attack Patients H....A study of 2,160 people who had heart attacks fou... the heart attacks (Article, p. 785). Approximatel...s of a myocardial infarction.......Further, heart ...
...couple feels during an ordinary half-hour argument...rom wounds by at least one day, a new study has sh...is routinely hostile toward each other, the delay ...esults of this study have major financial implicat...
...otein responsible for persistent pain, causing the...ared, says U of T researchers. The findings could ...dians who suffer from chronic pain. ...... The stu...of Neuroscience, shows how inflammation in mice in...
...65 who lacked health insurance for at least a year... 2004, according to a new University of North Caro...-elderly residents without health insurance varied...nt in Wake County to a high of 28.3 percent in Tyr...
health news:Annals of Internal Medicine tip sheet for Dec. 6, 2005 2health news:Stress substantially slows human body's ability to heal 2health news:Stress substantially slows human body's ability to heal 3health news:Inflammation linked to chronic pain: Study 2health news:Percentage of North Carolinians lacking health insurance rises, UNC study shows 2
...le evidence to support the belief that a person's ...iving cancer, finds a study in this week's BMJ.......f psychological coping styles (including fighting ...idance) and survival from or recurrence of cancer....
...v. 9, 2002 A preliminary study reports that enhan...ms of Crohn's disease in 80 percent of patients wi...nflammatory gastrointestinal disorder. ......The r...he Lancet by investigators at Washington Universit...
...agement teams, faced with an approaching hurricane...es for real-time decision making on issues ranging...uating assisted-living facilities by using a compu... The research team says the system also can assist...
... Although individuals vary widely, on average, pre...formation -- including understanding what they see...s deficit in processing speed is already present i...e does not narrow with age. The research is publis...
health news:New treatment strategy for Crohn's disease shows early promise 2health news:New treatment strategy for Crohn's disease shows early promise 3health news:Map data goes live with voice, gesture-based computer system 2health news:Map data goes live with voice, gesture-based computer system 3health news:Pre-term infants slower than full-terms at processing information 2