Study: obesity impairs immune response of mice, boosts chances of dying from influenza infection

CHAPEL HILL Obesity apparently reduces laboratory mice's ability to turn on elements of their immune systems needed for controlling influenza infection, a new University of North Carolina at Chapel Hill School of Medicine study shows.

The findings raise the possibility that obesity in humans has a similar effect, scientists say.

Compared to other mice of normal weight, which were otherwise identical, obese mice were 10 times as likely to die when infected with the flu virus. Four percent of lean mice died during the experiments, compared with 40 percent of the extra fat ones.

The study, presented in San Diego Saturday (April 2) at an American Society of Nutritional Sciences scientific meeting, part of a larger experimental biology meeting, is the first of its kind to examine the effects of obesity on the immune response to infection with influenza.

Nutrition doctoral student Alexia Smith and Dr. Melinda A. Beck, associate professor of pediatrics at the UNC School of Medicine, led the research and reported the findings.

"Numerous marked alterations seen in the mice's immune response suggest that the growing obese population is at increased risk for immune dysfunction during influenza infection, which may lead in humans, as it did in the mice, to increased mortality," Beck said. "Influenza virus currently is responsible for 36,000 deaths and 114,000 hospitalizations in the United States each year."

Mice are a common model in influenza virus infection studies, Beck said. In her UNC laboratory, 35 mice fed a high-fat, high-sugar diet for five months grew 37 percent heavier than 35 mice fed a regular rodent diet high in carbohydrates. The obese mice had a body fat percentage of 31 percent, compared to 21 percent in the lean mice.

"Following influenza infection at five months, which is adulthood for mice, the obese mice demonstrated significantly decreased capacity in every step of the inflammatory immune response i

Contact: David Williamson
University of North Carolina at Chapel Hill

Page: 1 2

Related medicine news :

1. Study: Directly observed HIV therapy for children is promising
2. Study: Who claims to be a pediatrician?
3. Study: Chain-owned nursing homes hurt by too much standardization
4. Study: Breast cancer in younger black women is more likely to be an aggressive variety
5. Study: Super-sizing your food takes a hidden toll on your pocketbook
6. Study: Exercise, diet may protect against colorectal cancer
7. Study: Paramedics save more lives when they dont follow the rules
8. Study: Local TV news covers health a lot, but not always well
9. Study: Hospitals rated top 5 percent have mortality rates 27 percent lower
10. Study: Exercise helps speed wound healing in older adults
11. Study: N.C. parents want tobacco use prevention to become higher priority

Post Your Comments:

(Date:3/15/2020)... ... March 14, 2020 , ... ... surrounding the Coronavirus (COVID-19) pandemic, National HouseCheck Corporation (‘HouseCheck’) is bringing their ... and employees. HouseCheck has launched its nationwide Virus Remediation and Decontamination program ...
(Date:3/13/2020)... ... March 13, 2020 , ... The Berman Law Group today announced that it ... Province, the City of Wuhan, and several Chinese government ministries, on behalf of residents ... filed in the Southern District of Florida, and seeks billions of dollars in compensatory ...
(Date:3/13/2020)... ... March 13, 2020 , ... The Pennsylvania ... helping professionals to meet a baseline of new educational regulations and standards. ... services for ABA organizations, has developed web-based training programs to help support ABA ...
(Date:3/13/2020)... ... , ... Ship Smart, a company specializing in small moves, has a unique moving solution for ... universities and schools for over 20 years. Not only are items picked up fast, but ... willing to pick up their belongings as long as they submit a written authorization and ...
(Date:3/13/2020)... BARBARA, Calif. (PRWEB) , ... March 13, 2020 ... ... and emergency management organizations administering aid to communities impacted by the Coronavirus (COVID-19) ... helping them reduce the spread of the infectious virus. , With COVID-19 being ...
Breaking Medicine News(10 mins):
(Date:3/27/2020)... ... March 27, 2020 , ... Shady Grove Fertility ... access to board certified fertility specialists through virtual physician consults , thereby minimizing ... hallmarks of SGF over its 29 year history has always been to improve access ...
(Date:3/27/2020)... , ... March 27, 2020 , ... ... lifestyle, is privileged to present Dr. Timothy Katzen as a leading weight-loss and ... Haute Living partnership. , Haute Beauty offers a prominent collective of leading doctors ...
(Date:3/22/2020)... ... ... Since 1988, Gwatney dealerships have strived to make car buying simple for shoppers ... Gwatney Mazda is pleased to announce two new services designed to ensure the well-being ... The dealership’s new Home Test Drives and Delivery service is a 100% online sales ...
Breaking Medicine Technology:
Cached News: