HOME >> MEDICINE >> NEWS
Study by Einstein researchers could lead to a novel strategy for treating obesity

In their latest finding on the brain's role in controlling appetite and weight, researchers at the Albert Einstein College of Medicine have shown that reducing levels of fatty acids in the hypothalamus causes rats to overeat and become obese. Their results suggest that restoring fatty-acid levels in the brain may be a promising way to treat obesity. The study, published in the January 15th on-line edition of Nature Neuroscience, was led by Dr. Luciano Rossetti, director of the Diabetes Research Center at Einstein. (The paper will appear in print in the February issue.)

The brain's hypothalamus keeps track of the body's nutritional status by monitoring the blood levels of several different hormones and nutrients. Taking this information into account, the hypothalamus regulates our energy intake and metabolism.

In a study published last year in Science, Dr. Rossetti and his colleagues showed how the hypothalamus monitors and regulates glucose levels in the body. The present study shows that this brain region also monitors fatty acid levels and responds by controlling appetite.

The study focused on malonyl CoA, a molecule suspected of being one of the critical nutrients influencing hypothalamic regulation of eating behavior. Previous studies had shown that hypothalamic levels of malonyl CoA increase markedly after meals and are suppressed by fasting.

The Einstein researchers wanted to know whether sustained suppression of this nutrient within the hypothalamus could result in obesity. To find out, they piggybacked an enzyme known to degrade malonyl CoA onto an adeno-associated virus and injected the virus into the hypothalamus of rats. The injections caused a chronic decrease in malonyl CoA levels, which dramatically increased the rats' food intake and led to obesity that was maintained for at least four months.

"We showed in this study that disrupting malonyl-CoA levels in this region of the brain impairs the nutrient-sensing
'"/>

Contact: Karen Gardner
kgardner@aecom.yu.edu
718-430-3101
Albert Einstein College of Medicine
15-Jan-2006


Page: 1 2

Related medicine news :

1. Study, meta-analysis examine factors associated with death from heatstroke
2. Study says COPD testing is not measuring up
3. Study suggests loss of 2 types of neurons -- not just 1 -- triggers Parkinsons symptoms
4. Study reveals gaps in vaccine financing for underinsured children
5. Study suggests nonpharmaceutical interventions may be helpful in severe influenza outbreaks
6. Study shows radiofrequency ablation highly effective in treating kidney tumors
7. Study says normal but out-of-control enzyme may be culprit that signals some cells to become cancer
8. Study finds HIV protease inhibitor drugs may adversely affect the scaffolding of the cell nucleus
9. Study outlines how stroke, head injury can increase risk of Alzheimers disease
10. Study identifies new regulator of fat metabolism
11. Study shows Diachrome improves blood sugar control in people with type 2 diabetes

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/14/2019)... ... January 14, 2019 , ... ... household and personal-care products with a presence worldwide, today announced that it built ... Measured year-over-year, Modere sales grew by double-digits in North America, by more than ...
(Date:1/14/2019)... ... January 14, 2019 , ... Trees can be overweight ... homeowners should have trees pruned, and winter is a great time to clean things ... branches can lead to serious damage, especially during windy or icy storms. The crown ...
(Date:1/13/2019)... LIMEPORT, Pa. (PRWEB) , ... January 12, 2019 ... ... announce that it is celebrating its 35th year of service to the community, ... incredibly proud to be celebrating our 35th anniversary,” said New Vitae co-founder and ...
(Date:1/11/2019)... ... January 11, 2019 , ... In Partnership with the Smiles for ... underinsured individuals at its Burleson, TX office on February 9. , Dental ... cleanings and extractions . For more information, please visit the Monarch ...
(Date:1/11/2019)... ... , ... Women’s Excellence specializes in the excision of endometriosis, ... help restore fertility. , Endometriosis is a disease in which endometrial tissue grows ... ovaries, fallopian tubes, and the inner lining of the abdomen.  In more severe ...
Breaking Medicine News(10 mins):
(Date:1/15/2019)... ... , ... RMA of Connecticut, a leading fertility practice whose exceptional quality and ... that will demystify fertility age-related issues and will include complimentary fertility testing ... Age ,” will take place on Thursday, January 24th at 6 PM and will ...
(Date:1/15/2019)... ... January 15, 2019 , ... ... course locations for the 2019 Wound Certification Prep Course (WCPC), the leading comprehensive ... increased specialized knowledge in wound management, WCPC will be expanding its course to ...
(Date:1/15/2019)... , ... January 15, 2019 ... ... announced that Texas Health Resources (THR), the largest faith-based nonprofit health system ... wholly owned hospitals. According to MDsyncNET Co-Founder and CEO Brad Goldsmith, “We’re ...
Breaking Medicine Technology:
Cached News: