The results of the multicenter, randomized, three-way, crossover study of 77 chronic users of COX-2 inhibitors or nonselective NSAIDs found that esomeprazole maintained a pH of greater than 4.0 for 17.8 hours (74.3 percent) of the 24-hour period while lansoprazole maintained it for 15.9 hours (66.4 percent, P=.0003)) and pantoprazole for 14.6 hours (60.7 percent, P<.0001).
"It is well known that long-term NSAID users are at increased risk for stomach ulcers, which is often a deterrent to long-term treatment. Acid control can reduce this risk and proton pump inhibitors have been shown to reduce the incidence of ulcers associated with chronic NSAID use," said Jay L. Goldstein, M.D., Professor of Medicine, Vice Head for Clinical Affairs, Department of Medicine, University of Illinois at Chicago and lead investigator for the study. "PPIs provide the acid control necessary to reduce the risk of stomach ulcers, allowing patients to continue the use of medications that provide them with pain and inflammation relief. This study compares the ability of three proton pump inhibitors to control stomach acid."
Approximately 70 percent of people over the age of 65 take NSAIDs at least once a week and nearly half of them take seven doses or more per week. NSAID use is one of the most common causes of gastroduodenal injury in the United States. Approximately half of all people who regularly take NSAIDs have gastric erosions and between 15 percent and 30 percent have ulcers.1
Contact: David Albaugh