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Study establishes link between air pollution, ischemic strokes

BOSTON -- The risk of ischemic stroke which results when a blood clot travels to the brain increases with a rise in particulate air pollution, according to a study in Stroke: Journal of the American Heart Association. Led by researchers at Beth Israel Deaconess Medical Center (BIDMC) and the Harvard School of Public Health (HSPH), the findings are described in the October 27, 2005 on-line rapid access issue of the journal.

The study, which examined the air quality on a total of 37,000 days in nine separate cities, found that risk of hospitalization for ischemic stroke was one percent higher on days with relatively high levels of air pollution, compared with low-air pollution days, according to lead author Gregory Wellenius, Sc.D., postdoctoral fellow in cardiology at BIDMC.

"Although these effects sound relatively small, given the large number of people exposed to air pollution and the large number of people at risk for stroke, from a public-health perspective the actual number of strokes [we're talking about] could be significant," says Wellenius. Stroke is the third leading cause of death in the U.S., affecting more than 700,000 individuals each year.

Previous work by Wellenius and coauthors Murray Mittleman, MD, DrPH, of BIDMC's Cardiovascular Epidemiology Research Unit and Joel Schwartz, PhD, of HSPH had established a "consistent increased risk" for cardiac health problems associated with exposure to ambient air particles.

"Air pollution has been shown to trigger heart attacks and to aggravate the conditions of patients with congestive heart failure," says Mittleman, who is also Associate Professor of Medicine at Harvard Medical School. "These new findings, demonstrating that incidence of clot-based strokes also increase, is in keeping with our earlier data showing a relationship between air pollution and heart and lung disorders."

(The study also looked at the incidence of hemorrhagic stroke, which is caused by bleedi
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Contact: Bonnie Prescott
bprescot@bidmc.harvard.edu
617-667-7306
Beth Israel Deaconess Medical Center
28-Oct-2005


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