HOME >> MEDICINE >> NEWS
Study evaluates benefits and risks of tamoxifen and raloxifene for reducing risk of breast cancer

Raloxifene and tamoxifen are both effective in reducing the risk of invasive breast cancer, but each has potential disease and quality of life side effects that women and their physicians will need to consider, according to two reports and an editorial published online June 5 by JAMA. The papers are being published online to coincide with the scientific presentation of this information at the annual American Society of Clinical Oncology meeting in Atlanta. The papers will be published in the June 21 issue of JAMA.

Tamoxifen is a selective estrogen receptor modulator (SERM) that has been used to treat both early and advanced breast cancer for more than three decades, according to background information in the article. Raloxifene is a second-generation SERM currently used as a medication for the prevention and treatment of osteoporosis. But clinical trials have shown it may have a role in reducing the risk of invasive breast cancer in postmenopausal women.

Victor G. Vogel, M.D., M.H.S., from Magee-Womens Hospital, University of Pittsburgh School of Medicine, and colleagues from The National Surgical Adjuvant Breast and Bowel Project (NSABP), conducted a randomized clinical trial (Study of Tamoxifen and Raloxifene or STAR trial) at nearly 200 clinical centers throughout North America. Patients were 19,747 postmenopausal women with an average age of 58.5 years with an increased five-year breast cancer risk. The study patients were randomized to receive oral tamoxifen (20 mg/day) or raloxifene (60 mg/day) over five years.

"There were 163 cases of invasive breast cancer in women assigned to tamoxifen and 168 in those assigned to raloxifene (incidence, 4.30 per 1,000 vs. 4.41 per 1,000)," according to the study authors. There were fewer cases of noninvasive breast cancer in the tamoxifen group (57 cases) than in the raloxifene group (80 cases), while there were 36 cases of uterine cancer with tamoxifen and 23 with raloxifene; however, neit
'"/>

Contact: Clare Collins
412-352-2886
JAMA and Archives Journals
5-Jun-2006


Page: 1 2

Related medicine news :

1. Study, meta-analysis examine factors associated with death from heatstroke
2. Study says COPD testing is not measuring up
3. Study suggests loss of 2 types of neurons -- not just 1 -- triggers Parkinsons symptoms
4. Study reveals gaps in vaccine financing for underinsured children
5. Study suggests nonpharmaceutical interventions may be helpful in severe influenza outbreaks
6. Study shows radiofrequency ablation highly effective in treating kidney tumors
7. Study says normal but out-of-control enzyme may be culprit that signals some cells to become cancer
8. Study finds HIV protease inhibitor drugs may adversely affect the scaffolding of the cell nucleus
9. Study outlines how stroke, head injury can increase risk of Alzheimers disease
10. Study identifies new regulator of fat metabolism
11. Study shows Diachrome improves blood sugar control in people with type 2 diabetes

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/13/2018)... ... November 13, 2018 , ... Health iPASS today announced it has topped ... QED Investors – the financial technology-focused venture capital fund led by Nigel Morris, co-founder ... a first of its kind, non-recourse guarantee of patient payments to medical providers who ...
(Date:11/13/2018)... ... November 13, 2018 , ... ... missing teeth in Waterford, CT and surrounding areas to consider dental implants ... Americans, but dental implants prove time and time again to restore function and ...
(Date:11/13/2018)... (PRWEB) , ... November 13, 2018 , ... ... Hotel & Suites Pittsburgh Downtown, 1 Bigelow Square, in Pennsylvania, will be an ... hours of relevant, practical instruction in the management of chronic pain. , ...
(Date:11/11/2018)... LAUDERDALE, Fla. (PRWEB) , ... November 10, 2018 ... ... of scrub uniforms and accessories for healthcare and hospitality industries recently remodeled their ... to lack of progress, Uniform Advantage has made it their goal to consistently ...
(Date:11/11/2018)... ... 2018 , ... Cortney Afton, registered dietitian and nutrition care coordinator for Kalamazoo ... positive impact on the lives of her consumers. “Every day when I leave my ... wonderful resources in Kalamazoo and this Mobile Kitchen initiative is one of them.” , ...
Breaking Medicine News(10 mins):
(Date:11/9/2018)... DALLAS (PRWEB) , ... November 09, 2018 , ... ... University (ACU) has received accreditation from the Commission on Collegiate Nursing Education ( ... rigorous curriculum according to the American Association of Colleges of Nursing (AACN) essentials ...
(Date:11/9/2018)... ... November 09, 2018 , ... The holidays are just around the corner, ... have dental braces, those fun foods can wreak havoc. Sticky toffee, nuts, chips, and ... brackets, resulting in inconvenient and expensive trips to the dentist or orthodontist. , Lynn ...
(Date:11/9/2018)... ... , ... Realtor John Lyons, of Baird and Warner, pledges to donate $200 per transaction to ... to close 10 more transactions before the end of the year, and next year I ... Achievement award from the Chicago Association of Realtors for the past three years. , The ...
Breaking Medicine Technology:
Cached News: