HOME >> MEDICINE >> NEWS
Study first to show potential of light-activated gene therapy for knee injuries

ridement relieve pain and inflammation, but leave a hole in the cartilage. Other techniques are too expensive and invasive or apply to few injuries, according to the study authors. Given the limits of surgical repair, researchers have been attempting for years to use gene therapy to truly repair, or re-grow, articular cartilage.

The blueprint for the human body is encoded in genes, which store information that is converted into proteins which carry out bodily functions. Gene therapy works by inserting specially designed genes into cells that can, for instance, direct cells to divide, which makes a tissue grow. Animals like amphibians re-grow amputated limbs, including articular cartilage, but humans grow cartilage only once, during development, without help.

To deliver the genes into cells, researchers need an effective delivery vehicle, or vector. Viruses have evolved for millions of years to invade human cells and insert DNA into their prey. Researchers have harnessed their useful qualities while removing the harmful ones. Unfortunately, no viral vector to date has been able to turn on genes only in the damaged areas because they infect cells in nearby healthy tissue as well.

Sunlight: A Specific Solution

The solution to the problem of how to target some cells for gene therapy, while missing their neighbors, came from a strange source: our cellular defenses against sunlight. The sun gives off ultraviolet (UV) light, which can cause destructive changes (genetic mutations) when exposed to sensitive molecules like DNA. If not defended against, the changes in DNA caused by UV light would cause humans to constantly develop cancer, for instance, in exposed tissue. Thus, an SOS system evolved that calls for genetic repairs when UV light causes too many mutations. Specifically, UV light turns on signaling proteins called stress kinases, which activate DNA polymerase, the enzyme that re-builds DNA chains when damaged.


'"/>

Contact: Greg Williams
Greg_Williams@urmc.rochester.edu
University of Rochester Medical Center
24-Apr-2006


Page: 1 2 3 4 5 6

Related medicine news :

1. Study, meta-analysis examine factors associated with death from heatstroke
2. Study says COPD testing is not measuring up
3. Study suggests loss of 2 types of neurons -- not just 1 -- triggers Parkinsons symptoms
4. Study reveals gaps in vaccine financing for underinsured children
5. Study suggests nonpharmaceutical interventions may be helpful in severe influenza outbreaks
6. Study shows radiofrequency ablation highly effective in treating kidney tumors
7. Study says normal but out-of-control enzyme may be culprit that signals some cells to become cancer
8. Study finds HIV protease inhibitor drugs may adversely affect the scaffolding of the cell nucleus
9. Study outlines how stroke, head injury can increase risk of Alzheimers disease
10. Study identifies new regulator of fat metabolism
11. Study shows Diachrome improves blood sugar control in people with type 2 diabetes

Post Your Comments:
(Date:7/23/2014)... 2014 FCCI Insurance Group has been ... American Heart Association for helping employees eat better and ... Fit-Friendly Worksite in 2013, 2011, and 2010, and as ... employee health and wellness an important priority. We’re committed ... at the top of their game, and we are ...
(Date:7/23/2014)... 2014 Being overweight is no longer ... suggests that eating a diet high in processed and ... the risk for a host of diseases and weight ... in the bloodstream. , The body makes cholesterol, ... can cause thick, hard plaque to build up, clogging ...
(Date:7/23/2014)... 2014 Researchers in Turkey say a ... yellow pigment in the spice turmeric, and an immunosuppressor ... lab. To read the full story on Surviving ... University in Ankara, Turkey pretreated mesothelioma cells ... them to two platinum-based chemotherapy drugs with promising results. ...
(Date:7/23/2014)... (PRWEB) July 23, 2014 Daily Face & ... cheaper and safer alternative to Botox called Stem Cell ... is an anti-aging product used to help people smooth, tone, ... Serum can be used as a safe alternative to Botox, ... have any toxins or health risks as opposed to Botox. ...
(Date:7/23/2014)... Woodland Hills’ top cosmetic dentists ... bad breath that the condition is more than just a ... Jivraj and Dr. Mamaly Reshad of the Anacapa Dental Art ... some people may be overlooking an obvious sign of a ... an infection or chronic disease in the body,” Dr. Reshad ...
Breaking Medicine News(10 mins):Health News:FCCI Insurance Group Recognized as an American Heart Association Fit-Friendly Worksite 2Health News:FCCI Insurance Group Recognized as an American Heart Association Fit-Friendly Worksite 3Health News:Diet Doc’s Medical Weight Loss Programs Introduce Specialized Cholesterol Diet Plans that Deliver Fast Weight Loss and Reduce the Risk for Heart Attack and Stroke 2Health News:Diet Doc’s Medical Weight Loss Programs Introduce Specialized Cholesterol Diet Plans that Deliver Fast Weight Loss and Reduce the Risk for Heart Attack and Stroke 3Health News:New Research Finds Pretreatment of Mesothelioma Cells with These Two Compounds Boosts Chemotherapy Response, According to Surviving Mesothelioma 2Health News:New Research Finds Pretreatment of Mesothelioma Cells with These Two Compounds Boosts Chemotherapy Response, According to Surviving Mesothelioma 3Health News:Local Denver Skin Care Company Releases Safer Alternative to Botox 2Health News:Woodland Hills’ Top Cosmetic Dentists Offer 6 Tips on Causes of Bad Breath That Should Concern You 2Health News:Woodland Hills’ Top Cosmetic Dentists Offer 6 Tips on Causes of Bad Breath That Should Concern You 3Health News:Woodland Hills’ Top Cosmetic Dentists Offer 6 Tips on Causes of Bad Breath That Should Concern You 4Health News:Woodland Hills’ Top Cosmetic Dentists Offer 6 Tips on Causes of Bad Breath That Should Concern You 5
(Date:7/23/2014)... , July 23, 2014  Nearly 8,000 attendees will ... Cardinal Health,s annual Retail Business Conference (RBC), taking place ... Center. This year,s event encourages pharmacists to "Lead Change" ... communities and for their future. ... to network with their peers and learn new ways ...
(Date:7/23/2014)... Calif. , July 23, 2014  Cardica, Inc. (Nasdaq: ... financial results for its fiscal fourth quarter and year ended ... markets close. Cardica,s management will host a conference call at ... provide an update on the company,s business. Conference ... 7, 2014, at 4:30 p.m. Eastern Time via phone, please ...
(Date:7/23/2014)... a leader in R&D for new therapeutic solutions for the ... Growth Factor) has been designated as an orphan drug by ... The candidate drug, developed by the research of Dompe, has ... neurotrophic keratitis, a degenerative corneal disease that affects less than ... a cure. This is the second orphan drug designation by ...
Breaking Medicine Technology:Cardinal Health Encourages Independent Pharmacists to Lead Change at 24th Annual Retail Business Conference 2Cardinal Health Encourages Independent Pharmacists to Lead Change at 24th Annual Retail Business Conference 3Cardinal Health Encourages Independent Pharmacists to Lead Change at 24th Annual Retail Business Conference 4Cardinal Health Encourages Independent Pharmacists to Lead Change at 24th Annual Retail Business Conference 5Cardinal Health Encourages Independent Pharmacists to Lead Change at 24th Annual Retail Business Conference 6Cardica to Announce Fiscal 2014 Fourth Quarter and Full Year Financial Results on Thursday, August 7, 2014 2Dompe announces the Food and Drug Administration (FDA) has granted orphan drug designation to its rhNGF-based treatment for neurotrophic keratitis 2Dompe announces the Food and Drug Administration (FDA) has granted orphan drug designation to its rhNGF-based treatment for neurotrophic keratitis 3Dompe announces the Food and Drug Administration (FDA) has granted orphan drug designation to its rhNGF-based treatment for neurotrophic keratitis 4
Cached News: