HOME >> MEDICINE >> NEWS
Study identifies new regulator of fat metabolism

BOSTON -- Over the past several years, animal studies have shown that high-fat, low-carbohydrate ketogenic diets cause demonstrable changes in metabolism and subsequent weight loss. Now, researchers at Beth Israel Deaconess Medical Center (BIDMC) have identified a key mechanism behind this turn of events. Their findings, which appear in the June 2007 issue of Cell Metabolism, demonstrate that a liver hormone known as FGF21 is required to oxidize fatty acids and thereby burn calories.

"When the diet is extremely low in starches and sugars, blood sugar levels drop substantially so that muscle and brain have to turn to alternative fuels, explains senior author Eleftheria Maratos-Flier, MD, an investigator in the Department of Endocrinology, Diabetes and Metabolism at BIDMC and Associate Professor of Medicine at Harvard Medical School. Consequently, fatty acids are broken down in the liver and converted to ketones, which then serve as a major fuel source.

Known as ketosis, this metabolic state is characterized by extremely low insulin levels, as would occur during periods of fasting or starvation or while consuming a low-carb diet, such as the popular Atkins diet model.

For the past several years, Maratos-Fliers laboratory has been studying the physiologic states of animals consuming various types of diets -- including standard animal chow diets and diets moderately high in both fats and carbohydrates, as well as ketogenic diets. And she has found through her experiments that even though mice are fed exactly the same number of calories, the composition of the calories causes them to gain weight in different ways.

The differences in weight gain reflect differences in metabolic rates, she explains. These, in turn, result in hormonal changes that lead to different disposition of the calories.

In this latest paper, Maratos-Flier and colleagues studied mice that had been fed a ketogenic diet high in both saturated fat an
'"/>

Contact: Bonnie Prescott
bprescot@bidmc.harvard.edu
617-667-7306
Beth Israel Deaconess Medical Center
5-Jun-2007


Page: 1 2 3

Related medicine news :

1. Study, meta-analysis examine factors associated with death from heatstroke
2. Study says COPD testing is not measuring up
3. Study suggests loss of 2 types of neurons -- not just 1 -- triggers Parkinsons symptoms
4. Study reveals gaps in vaccine financing for underinsured children
5. Study suggests nonpharmaceutical interventions may be helpful in severe influenza outbreaks
6. Study shows radiofrequency ablation highly effective in treating kidney tumors
7. Study says normal but out-of-control enzyme may be culprit that signals some cells to become cancer
8. Study finds HIV protease inhibitor drugs may adversely affect the scaffolding of the cell nucleus
9. Study outlines how stroke, head injury can increase risk of Alzheimers disease
10. Study shows Diachrome improves blood sugar control in people with type 2 diabetes
11. Study examines characteristics of female high school students who report steroid use

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/5/2019)... (PRWEB) , ... December 05, 2019 , ... ... with milestones ranging from launching exceptional products that help people embrace, achieve, and ... world. , “We’ve never been more committed to our mission of impacting world ...
(Date:12/4/2019)... ... December 04, 2019 , ... A November 12 ... cities offer them as public transit options. The article highlighted the life-changing or life-ending ... confined to a bed to a rider fatality after an incident with a vehicle. ...
(Date:12/4/2019)... ... 04, 2019 , ... WEDI , the nation’s leading nonprofit authority on ... a trusted advisor to the U.S. Department of Health and Human Services (HHS), announced ... the 2019 WEDI Winter Conference in Arlington, Va. on Wednesday, December 4. , “The ...
(Date:12/4/2019)... ... December 04, 2019 , ... While the holidays are a time for ... said Texas A&M AgriLife Extension Service specialists. , “There are many ... benefit your overall wellness,” said Joyce Cavanagh, AgriLife Extension specialist in family economics, College ...
(Date:12/4/2019)... YORK (PRWEB) , ... December 04, 2019 , ... ... Phase I study of AZD4041 for treating tobacco use and dependence. The study ... a central nervous system (CNS) penetrant antagonist of orexin-1 (hypocretin-1) receptors that is ...
Breaking Medicine News(10 mins):
(Date:12/6/2019)... ... December 06, 2019 , ... Kindred ... expansion in services. While Kindred Nutrition and Wellness will continue to focus ... now happy to offer Individual and Family Therapy and Yoga. , Kindred Nutrition ...
(Date:12/5/2019)... ... , ... Intelligent.com, a trusted resource for online degree rankings ... for 2020. The comprehensive research guide is based on an assessment of 67 ... curriculum quality, graduation rate, reputation, and post-graduate employment. , The 2020 rankings ...
(Date:12/4/2019)... ST. LOUIS (PRWEB) , ... ... ... healthcare industry leader in delivering solutions designed for improved financial, operational and ... Officer, has earned the Fellow designation from the American College of Healthcare ...
Breaking Medicine Technology:
Cached News: