HOME >> MEDICINE >> NEWS
Study identifies new regulator of fat metabolism

BOSTON -- Over the past several years, animal studies have shown that high-fat, low-carbohydrate ketogenic diets cause demonstrable changes in metabolism and subsequent weight loss. Now, researchers at Beth Israel Deaconess Medical Center (BIDMC) have identified a key mechanism behind this turn of events. Their findings, which appear in the June 2007 issue of Cell Metabolism, demonstrate that a liver hormone known as FGF21 is required to oxidize fatty acids and thereby burn calories.

"When the diet is extremely low in starches and sugars, blood sugar levels drop substantially so that muscle and brain have to turn to alternative fuels, explains senior author Eleftheria Maratos-Flier, MD, an investigator in the Department of Endocrinology, Diabetes and Metabolism at BIDMC and Associate Professor of Medicine at Harvard Medical School. Consequently, fatty acids are broken down in the liver and converted to ketones, which then serve as a major fuel source.

Known as ketosis, this metabolic state is characterized by extremely low insulin levels, as would occur during periods of fasting or starvation or while consuming a low-carb diet, such as the popular Atkins diet model.

For the past several years, Maratos-Fliers laboratory has been studying the physiologic states of animals consuming various types of diets -- including standard animal chow diets and diets moderately high in both fats and carbohydrates, as well as ketogenic diets. And she has found through her experiments that even though mice are fed exactly the same number of calories, the composition of the calories causes them to gain weight in different ways.

The differences in weight gain reflect differences in metabolic rates, she explains. These, in turn, result in hormonal changes that lead to different disposition of the calories.

In this latest paper, Maratos-Flier and colleagues studied mice that had been fed a ketogenic diet high in both saturated fat an
'"/>

Contact: Bonnie Prescott
bprescot@bidmc.harvard.edu
617-667-7306
Beth Israel Deaconess Medical Center
5-Jun-2007


Page: 1 2 3

Related medicine news :

1. Study, meta-analysis examine factors associated with death from heatstroke
2. Study says COPD testing is not measuring up
3. Study suggests loss of 2 types of neurons -- not just 1 -- triggers Parkinsons symptoms
4. Study reveals gaps in vaccine financing for underinsured children
5. Study suggests nonpharmaceutical interventions may be helpful in severe influenza outbreaks
6. Study shows radiofrequency ablation highly effective in treating kidney tumors
7. Study says normal but out-of-control enzyme may be culprit that signals some cells to become cancer
8. Study finds HIV protease inhibitor drugs may adversely affect the scaffolding of the cell nucleus
9. Study outlines how stroke, head injury can increase risk of Alzheimers disease
10. Study shows Diachrome improves blood sugar control in people with type 2 diabetes
11. Study examines characteristics of female high school students who report steroid use

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/5/2020)... , ... August 04, 2020 , ... Today, Power to ... Child Health Programs (AMCHP) with the 2020 Innovation Station Best Practice Award. The One ... and under what circumstances to get pregnant and have a child. One Key Question ...
(Date:8/3/2020)... ... , ... The process uses needlepoint bipolar ionization (NPBI™) and ... Phoenix airport, the Mayo Clinic, Ramstein Air Force Base, Harvard University, dozens of ... the manufacturers of the system, most viruses and other particles in the air ...
(Date:7/31/2020)... , ... July 31, 2020 , ... ... accepting new patients to The Dental Studio of Midland for groundbreaking laser ... As a result, these patients are able to experience the many advantages of ...
(Date:7/22/2020)... ... July 22, 2020 , ... Whatever we call them – sunspots, age spots, ... summer glow,” notes Angie Seelal, a Certified Registered Physician Assistant specializing in Dermatology with ... years later and make us look older.” , In terms of the name, ‘sunspots’ ...
(Date:7/22/2020)... ... July 22, 2020 , ... Ocean Tomo Transactions, LLC will ... manufacturing processes from Brock University for jurisdictions throughout North America, Europe and Asia. ... University provides the manufacturing processes of novel opioid related compositions for pain management ...
Breaking Medicine News(10 mins):
(Date:8/5/2020)... ... 04, 2020 , ... In an informal poll of 150 fans, conducted by ... refreshed Minnesota Twins “Minnie and Paul” logo that is more racially and culturally sensitive ... well before the civil rights movement in the United States. The Minnesota Twins have ...
(Date:8/5/2020)... ... August 05, 2020 , ... ... Programs: , Best Practices During COVID-19, An FDAnews Webinar, Wednesday, Aug. 19, ... maintaining a controlled cleanroom is never simple and COVID-19 has made it ...
(Date:8/3/2020)... ... , ... LaVoieHealthScience (LHS), an integrated investor and public relations consulting ... President, CEO and Founder of LHS, has been named to the PharmaVOICE 100 ... 100 has honored more than 1,500 industry executives for their contributions to the life ...
Breaking Medicine Technology:
Cached News: