HOME >> MEDICINE >> NEWS
Study identifies possible mechanism for brain damage in Huntington's disease

Researchers from the MassGeneral Institute for Neurodegenerative Disease (MIND) have identified a possible mechanism underlying how the gene mutation that causes Huntington's disease (HD) leads to the degeneration and death of brain cells. In the Oct. 6 issue of Cell, they show that the abnormal form of the huntingtin protein, the product of the HD gene mutation, interferes with the production of a protein critical to cellular energy metabolism. The discovery is the first to bring together two processes believed to be involved in the pathology of HD the conversion of genetic information into proteins and the production of energy within cells.

"Our study indicates that these two pathogenic mechanisms are linked, in that disruption of gene transcription by mutant huntingtin leads to abnormal energy metabolism, which affects energy-dependent cellular processes and results in neurodegeneration," says Dimitri Krainc, MD, PhD, of MIND and the MGH Department of Neurology, who led the research team. "The role of mitochondria [subcellular structures that produce the cells' energy] in the process of nerve cell dysfunction and death is an emerging theme in neurodegenerative disorders, but the mechanism behind HD has been elusive."

HD causes the degeneration and death of cells in the basal ganglia an area deep within the brain particularly in a structure called the striatum. Although the precise function of the huntingtin protein is still unknown, recent studies have suggested that the mutant form directly interferes with transcription of neuronal genes. Evidence also has pointed to disruptions in cellular energy metabolism as key factors in HD. As a result, the MIND team focused on a protein called PGC-1a, which is known to regulate energy in cells throughout the body. Their previous research had shown that mice in which the PGC-1a gene had been knocked out developed brain lesions in the striatum.

To investigate the possible effect of th
'"/>

Contact: Sue McGreevey
smcgreevey@partners.org
617-724-2764
Massachusetts General Hospital
5-Oct-2006


Page: 1 2 3

Related medicine news :

1. Study, meta-analysis examine factors associated with death from heatstroke
2. Study says COPD testing is not measuring up
3. Study suggests loss of 2 types of neurons -- not just 1 -- triggers Parkinsons symptoms
4. Study reveals gaps in vaccine financing for underinsured children
5. Study suggests nonpharmaceutical interventions may be helpful in severe influenza outbreaks
6. Study shows radiofrequency ablation highly effective in treating kidney tumors
7. Study says normal but out-of-control enzyme may be culprit that signals some cells to become cancer
8. Study finds HIV protease inhibitor drugs may adversely affect the scaffolding of the cell nucleus
9. Study outlines how stroke, head injury can increase risk of Alzheimers disease
10. Study identifies new regulator of fat metabolism
11. Study shows Diachrome improves blood sugar control in people with type 2 diabetes

Post Your Comments:
(Date:5/28/2015)... The second episode of “Extreme Weight ... share a need to transform their lives. Josh (29 years ... struggling to deal with the death of his father. Kelli ... Kansas City, MO, who went into depression after her playing ... will be featured in one episode of “Extreme Weight Loss” ...
(Date:5/27/2015)... Cincinnati, Ohio (PRWEB) May 28, 2015 Calls ... Effort , A new nationwide initiative – a “Summer ... Tri-State to create and build partnerships to grow the number ... VAMC is renewing its commitment to Veterans by inviting the ... an open house June 29, 2015 from 1 – 3:00 ...
(Date:5/27/2015)... (PRWEB) May 27, 2015 Western University ... by a few historic firsts -- and one profound ... Pasadena Civic Center marked the first time the university ... first time a Graduate College of Biomedical Sciences (GCBS) ... the Pacific (COMP). , The university’s fifth and final ...
(Date:5/27/2015)... 27, 2015 “We are honored to ... executive vice president and vice president of clinical affairs ... possible allows us to provide comprehensive care to more ... , SSCHC provides clinical care and behavioral health services ... in 2014, many of whom took advantage of the ...
(Date:5/27/2015)... May 27, 2015 While hair transplantation ... loss, a new pilot study conducted by a physician ... (ISHRS) has found hair follicle grafting can help treat ... was partially funded by ISHRS, which offers research grants ... hair restoration. , In the past decade, numerous ...
Breaking Medicine News(10 mins):Health News:“Extreme Weight Loss”: Josh and Kelli’s Journeys Begin at the University of Colorado Anschutz Health and Wellness Center 2Health News:“Extreme Weight Loss”: Josh and Kelli’s Journeys Begin at the University of Colorado Anschutz Health and Wellness Center 3Health News:VA Begins “Summer of Service” to Bolster Volunteer Assistance for Veterans 2Health News:VA Begins “Summer of Service” to Bolster Volunteer Assistance for Veterans 3Health News:WesternU Commencement Celebrates Achievements of Graduates and Founding President 2Health News:WesternU Commencement Celebrates Achievements of Graduates and Founding President 3Health News:WesternU Commencement Celebrates Achievements of Graduates and Founding President 4Health News:WesternU Commencement Celebrates Achievements of Graduates and Founding President 5Health News:Sixteenth Street Community Health Centers To Expand Primary Care and Behavioral Health Services Through $1 Million Grant From Aurora's Better Together Fund 2Health News:New Research Finds Hair Grafting a Promising Therapy for Chronic Leg Ulcers - International Society of Hair Restoration Surgery Awards Research Grant 2Health News:New Research Finds Hair Grafting a Promising Therapy for Chronic Leg Ulcers - International Society of Hair Restoration Surgery Awards Research Grant 3
(Date:5/27/2015)... May 27, 2015 The report " Tube ... (Cosmetics & Oral Care, Food & beverages, Pharmaceuticals, Consumer Goods), ... by Region - Trends & Forecasts to 2020", published by ... grow at a CAGR of 6.65% from 2015, to reach ... market data Tables and   61 F igures spread ...
(Date:5/27/2015)... 2015 Research and Markets( http://www.researchandmarkets.com/research/v7nm4b/2015_strategies ) ... Strategies in the Global Coagulation Testing Market" ... seven-country report contains 650 pages, 150 tables, and ... market entrants identify and evaluate business opportunities emerging ... next five years. The report explores ...
(Date:5/27/2015)... Research and Markets( http://www.researchandmarkets.com/research/55zkmp/2015_strategies ) has ... in the US Flow Cytometry Market" report ... a comprehensive analysis of the US flow cytometry ... the French flow cytometry practice, as well as ... with significant market impact during the next five ...
Breaking Medicine Technology:Tube Packaging Market Worth $8.63 Billion by 2020 2Tube Packaging Market Worth $8.63 Billion by 2020 3Tube Packaging Market Worth $8.63 Billion by 2020 4Global Coagulation Testing Market Strategies 2015 2Global Coagulation Testing Market Strategies 2015 32015 Strategies in the US Flow Cytometry Market 2
Cached News: