HOME >> MEDICINE >> NEWS
Study identifies potential drug target for Huntington's disease

An enzyme known to be critical for the repair of damaged cells and the maintenance of cellular energy may be a useful target for new strategies to treat Huntington's disease (HD) and other disorders characterized by low cellular energy levels. In the August issue of Chemistry & Biology, a research team from the MassGeneral Institute for Neurodegenerative Disease (MIND) describes their discovery of a novel inhibitor of Poly (ADP-ribose) polymerase (PARP1) and their findings that PARP1 inhibitors can protect HD-affected cells from damage in laboratory assays.

"While PARP1 is essential for the repair of damaged DNA, we also know that, if overactivated, it can cause cell death by excessive energy depletion," says Aleksey Kazantsev, PhD, director of the MIND High Throughput Drug Screening Laboratory, who led the current study. "It has recently been shown that neurons from patients with Huntington's appear to be energy-deficient, so we hypothesized that modest stresses that would be tolerated by healthy cells could send HD cells below a viable energy threshold and that blocking PARP1 activation could be protective."

To test this hypothesis the MIND researchers first ran a computer search of their small-molecule library for potential novel inhibitors of PARP1, searching for those with structural similarities to known inhibitors. "Safety and efficacy of human drugs depends on many factors, so it's hard to predict which inhibitor would be most effective against a specific disorder. The more diverse novel inhibitors can be identified, the more chances there are of developing safe and effective drugs," Kazantsev explains.

Two candidate molecules were identified as potential PARP1 inhibitors based on their structure, and both of them were confirmed to inhibit the enzyme's activity in an in vitro assay. However, when tested using cultured human and rat cells, only one of the candidate molecules, K245-14, successfully prevented the death o
'"/>

Contact: Sue McGreevey
smcgreevey@partners.org
617-724-2764
Massachusetts General Hospital
28-Jul-2006


Page: 1 2

Related medicine news :

1. Study, meta-analysis examine factors associated with death from heatstroke
2. Study says COPD testing is not measuring up
3. Study suggests loss of 2 types of neurons -- not just 1 -- triggers Parkinsons symptoms
4. Study reveals gaps in vaccine financing for underinsured children
5. Study suggests nonpharmaceutical interventions may be helpful in severe influenza outbreaks
6. Study shows radiofrequency ablation highly effective in treating kidney tumors
7. Study says normal but out-of-control enzyme may be culprit that signals some cells to become cancer
8. Study finds HIV protease inhibitor drugs may adversely affect the scaffolding of the cell nucleus
9. Study outlines how stroke, head injury can increase risk of Alzheimers disease
10. Study identifies new regulator of fat metabolism
11. Study shows Diachrome improves blood sugar control in people with type 2 diabetes

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Study identifies potential drug target for Huntington disease

(Date:4/20/2015)... 2015 At the famous Avalon Hollywood ... Movie Awards” EcoLuxe Lounge, with Choices Recovery as the ... of sustainable product placement in TV and film, gathered ... and ecologically sound goods and services for this daylong ... hosted the Choices Celebrity Interview Lounge, speaking with many ...
(Date:4/20/2015)... (PRWEB) April 20, 2015 Western ... Donahue, DNP, RN, NEA-BC, FAAN who was named ... Education and Research in September 2014, is transitioning ... Officer to lead the development of Western Connecticut ... newly created role, Donahue will be responsible for ...
(Date:4/20/2015)... NJ (PRWEB) April 20, 2015 The normal ... stroke. There’s nothing more we could do.” Especially if the ... , Today, the response should be much different. So it’s ... question: “What more can be done?” , Not every ... “There is something that can be done.” But, according to ...
(Date:4/20/2015)... York (PRWEB) April 20, 2015 ... representing the U.S. health insurance industry, is seeking ... of the recent controversy involving surgical tools called ... to U.S. Senator Robert Casey (D-PA) dated April ... surrounding uterine morcellation point to “serious gaps in ...
(Date:4/20/2015)... 20, 2015 TROY Healthcare Solutions will ... Enterprise (TSPE) software, which provides the ultimate level of ... 6 at the Anthem Suite Hotel in the Socrates ... 11 AM. , Beginning at 7 AM, TROY Healthcare ... AM, TROY Healthcare Solutions will offer brief 15-20 minute ...
Breaking Medicine News(10 mins):Health News:Choices Recovery South Bend Talks About Healthy Decisions with TV's Adrienne Janic 2Health News:Nursing Executive to Develop and Lead Nursing Leadership Program at Western Connecticut Health Network 2Health News:"What More Can Be Done?” – The Critical Question That Can Save a Stroke Victim 2Health News:"What More Can Be Done?” – The Critical Question That Can Save a Stroke Victim 3Health News:Power Morcellator Lawyers at Bernstein Liebhard LLP Comment on Insurance Trade Group’s Call for Greater Regulation of Medical Devices 2Health News:Power Morcellator Lawyers at Bernstein Liebhard LLP Comment on Insurance Trade Group’s Call for Greater Regulation of Medical Devices 3Health News:Power Morcellator Lawyers at Bernstein Liebhard LLP Comment on Insurance Trade Group’s Call for Greater Regulation of Medical Devices 4Health News:TROY Healthcare to Offer Prescription Solutions that Could Save a Health System $100,000 2Health News:TROY Healthcare to Offer Prescription Solutions that Could Save a Health System $100,000 3
(Date:4/20/2015)... Increasing unnecessary regulations on drug plans could ... get their medications through a managed drug plan, according ... for Policy Analysis Senior Fellow Devon Herrick. ... managed efficiently helps makes medications affordable," says Herrick. "Blatant ... as consumer protections, but more often than not they ...
(Date:4/20/2015)... , April 20, 2015 International ... pleased to provide shareholders with the following update ... Products Historically, INIS has ... to fabricate several models of sealed sources for ... such as radiation therapy, security examination, and radiography.  ...
(Date:4/20/2015)... , April 20, 2015 Stand Up To Cancer ... of a $20 million Dream Team to attack the number ... the Annual Meeting of the American Association for Cancer Research ... that 221,000 people in the United States ... 2015, and 158,040 will die from it, making lung cancer ...
Breaking Medicine Technology:Restrictive Drug Plan Regulations Will Hurt Patients 2International Isotopes Inc. Provides Shareholders With An Update On New Opportunities And Positive Developments Within Its Existing Business Segments 2International Isotopes Inc. Provides Shareholders With An Update On New Opportunities And Positive Developments Within Its Existing Business Segments 3International Isotopes Inc. Provides Shareholders With An Update On New Opportunities And Positive Developments Within Its Existing Business Segments 4International Isotopes Inc. Provides Shareholders With An Update On New Opportunities And Positive Developments Within Its Existing Business Segments 5New SU2C-American Cancer Society Lung Cancer Dream Team Announced 2New SU2C-American Cancer Society Lung Cancer Dream Team Announced 3New SU2C-American Cancer Society Lung Cancer Dream Team Announced 4New SU2C-American Cancer Society Lung Cancer Dream Team Announced 5New SU2C-American Cancer Society Lung Cancer Dream Team Announced 6
Cached News: