HOME >> MEDICINE >> NEWS
Study looks for genetic predictors of hypertension

Whether genes responsible for a rare disorder that dramatically elevates blood pressure holds clues for identifying many people at risk for hypertension is the focus of a new study.

The rare disorder is Liddle syndrome, first reported in 1963 in a 15-year-old Alabama girl diagnosed with a blood pressure of 180/110 mmHg, says Dr. Yanbin Dong, molecular geneticist and cardiologist at the Medical College of Georgia.

Interestingly, an inexpensive diuretic worked best to manage her problem. Tests years later found the reason was that genes involved in the channel that recycles sodium from food into the body were drastically mutated. "This mutation enables sodium to come back into the body like a flood," says Dr. Dong.

Today he is looking at sodium channel genes implicated in Liddle syndrome to identify less severe changes that could be used to screen for hypertension risk in the general population.

"My hypothesis is if Liddle syndrome is caused by these nasty, drastic mutations, maybe the majority of hypertension can be caused by milder, less nasty polymorphisms or variations in the same genes," says Dr. Dong who received a $1.43 million grant from the National Heart, Lung and Blood Institute to see if he is correct.

He's recruiting 300 healthy blacks ages 15 to 19 with normal blood pressure to a Georgia Prevention Institute study that first measures sodium-handling following environmental stress, then analyzes the genes of those who don't handle it well.

Dr. Dong is exploring findings by Dr. Gregory A. Harshfield, director of the Georgia Prevention Institute, showing that some healthy youths, particularly black youths, continue to retain sodium after the stress that drove up their blood pressure is gone. This impaired stress-induced pressure natriuresis occurs in about 36 percent of healthy black youths and 25 percent of healthy white youths, according to Dr. Harshfield's studies.

The body naturally increases bloo
'"/>

Contact: Toni Baker
tbaker@mcg.edu
706-721-4421
Medical College of Georgia
19-Jun-2006


Page: 1 2

Related medicine news :

1. Study, meta-analysis examine factors associated with death from heatstroke
2. Study says COPD testing is not measuring up
3. Study suggests loss of 2 types of neurons -- not just 1 -- triggers Parkinsons symptoms
4. Study reveals gaps in vaccine financing for underinsured children
5. Study suggests nonpharmaceutical interventions may be helpful in severe influenza outbreaks
6. Study shows radiofrequency ablation highly effective in treating kidney tumors
7. Study says normal but out-of-control enzyme may be culprit that signals some cells to become cancer
8. Study finds HIV protease inhibitor drugs may adversely affect the scaffolding of the cell nucleus
9. Study outlines how stroke, head injury can increase risk of Alzheimers disease
10. Study identifies new regulator of fat metabolism
11. Study shows Diachrome improves blood sugar control in people with type 2 diabetes

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Study looks for genetic predictors hypertension

(Date:12/20/2014)... a distinguished special dress supplier, has just done something ... cut prices to all its prom dresses already, offering ... Many of the hottest styles are sold here like ... more. , A spokesman for MissyDress says, “The great ... prom dresses or sweetheart chiffon prom dresses, you will ...
(Date:12/20/2014)... December 20, 2014 The print component ... with a distribution of approximately 160,000 copies and an ... nationally through a vast social media strategy and across ... To explore the digital version of the campaign, ... exclusive interview with the ladies of CTV’s The Social. ...
(Date:12/20/2014)... York, New York (PRWEB) December 20, 2014 ... continue to move forward in U.S. courts, ... new study which suggests that children treated with ... a hormone linked to breast development and lactation. ... looked at 34 children and adolescents who began ...
(Date:12/20/2014)... Xarelto bleeding lawsuits filed by ... bleeding and other serious side effects will be consolidated ... for coordinated pretrial proceedings, Wright & Schulte LLC reports. ... an order Friday to transfer 21 Xarelto lawsuits and ... courts to the Louisiana district court for coordination by ...
(Date:12/19/2014)... (PRWEB) December 20, 2014 It’s very easy ... is something that is put to the wayside until Christmas ... still have that travel “itch” and that burning desire to ... accommodates families on their journey to Telluride with a no-fuss, ... visitors to and from the resort, and ensure that all ...
Breaking Medicine News(10 mins):Health News:MissyDress: The Prices of Prom Dresses Just Reduced 2Health News:The ladies of The Social urge Canadian women to put themselves first over the holiday season and into the new year in Mediaplanet’s “Women’s Health” campaign 2Health News:Risperdal Lawsuit News: Bernstein Liebhard LLP Notes Publication of Study Suggesting Medication May Raise Prolactin Levels in Children 2Health News:Risperdal Lawsuit News: Bernstein Liebhard LLP Notes Publication of Study Suggesting Medication May Raise Prolactin Levels in Children 3Health News:Risperdal Lawsuit News: Bernstein Liebhard LLP Notes Publication of Study Suggesting Medication May Raise Prolactin Levels in Children 4Health News:Xarelto Bleeding Lawsuits Consolidated To Louisiana Federal Court For Multi-District Litigation Reports Wright & Schulte LLC 2Health News:Xarelto Bleeding Lawsuits Consolidated To Louisiana Federal Court For Multi-District Litigation Reports Wright & Schulte LLC 3Health News:Xarelto Bleeding Lawsuits Consolidated To Louisiana Federal Court For Multi-District Litigation Reports Wright & Schulte LLC 4Health News:Days Inn Montrose Colorado Delivers Last Minute Holiday Season Ski Getaway Accommodations 2
(Date:12/19/2014)... NEW YORK , Dec. 18, 2014 ... meals, addressing hearing health was forgotten. But Audicus ... resolve to hear better this new year. ... condition facing the aging population, though it is often ... one in four has a hearing aid, mainly due ...
(Date:12/19/2014)... INC. (NYSE: RMD ) today announced that it ... on Thursday, January 22, 2015, after the New York Stock ... be issued after 1:00 p.m. US Pacific Time and the ... future outlook. The earnings call is scheduled to ... webcast of the call can be accessed on ResMed,s Investor ...
(Date:12/19/2014)... membrane market has witnessed robust development with the growth pace ... later starter. In 2012, the size of China ... the proportion worldwide soaring to 16.3%. It is projected that ... its growth rate by around 20% in the upcoming years ... RMB25 billion. An integrated membrane industrial system has ...
Breaking Medicine Technology:Audicus Will Help People Resolve to Hear Better in 2015 2ResMed To Announce Second Quarter 2015 Results 2Separation Membranes Market (Company, Country & Application) Research Reports for Global and Chinese Regions 2Separation Membranes Market (Company, Country & Application) Research Reports for Global and Chinese Regions 3
Cached News: